Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0159 | 0.1237 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0433 | 0.151 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0074 | 0.0433 | 0.1032 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0802 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0074 | 0.0433 | 0.1032 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.0936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0433 | 0.151 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.005 | 0.0205 | 0.0713 |
Brugia malayi | Latrophilin receptor protein 2 | 0.005 | 0.0205 | 0.0713 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0433 | 0.151 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.075 | 0.2615 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0057 | 0.0273 | 0.007 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0273 | 0.0257 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0127 | 0.0936 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0433 | 0.151 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0225 | 0.0782 |
Onchocerca volvulus | 0.0074 | 0.0433 | 0.3503 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0112 | 0.079 | 0.2753 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0433 | 0.151 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0802 | 1 |
Onchocerca volvulus | 0.0112 | 0.079 | 0.6388 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0113 | 0.0802 | 0.2241 |
Echinococcus granulosus | lamin dm0 | 0.0112 | 0.079 | 0.0598 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0159 | 0.1237 | 0.3873 |
Mycobacterium ulcerans | lipase LipD | 0.0074 | 0.0433 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0433 | 0.0858 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0244 | 0.085 |
Echinococcus multilocularis | tumor protein p63 | 0.1088 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0936 | 0.326 |
Brugia malayi | hypothetical protein | 0.0082 | 0.051 | 0.1777 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0113 | 0.0802 | 0.061 |
Brugia malayi | beta-lactamase | 0.0074 | 0.0433 | 0.151 |
Trichomonas vaginalis | esterase, putative | 0.0074 | 0.0433 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0433 | 0.151 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0433 | 0.1032 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0802 | 0.2794 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0074 | 0.0433 | 0.1032 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0074 | 0.0433 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0074 | 0.0433 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0074 | 0.0433 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0433 | 0.5 |
Brugia malayi | hypothetical protein | 0.0127 | 0.0936 | 0.326 |
Echinococcus granulosus | intermediate filament protein | 0.0112 | 0.079 | 0.0598 |
Loa Loa (eye worm) | TAR-binding protein | 0.0332 | 0.287 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0332 | 0.287 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0054 | 0.0244 | 0.004 |
Echinococcus multilocularis | lamin dm0 | 0.0112 | 0.079 | 0.0598 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0054 | 0.0244 | 0.004 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0127 | 0.0936 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0332 | 0.287 | 0.2721 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.006 | 0.03 | 0.1045 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0433 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.0433 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0771 | 0.2686 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.075 | 0.2048 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0158 | 0.1221 | 0.4253 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0074 | 0.0433 | 0.1032 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0127 | 0.0936 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.006 | 0.03 | 0.1045 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0127 | 0.0936 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0332 | 0.287 | 0.2721 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0802 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0113 | 0.0802 | 0.061 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0265 | 0.2238 | 0.7797 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0332 | 0.287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0205 | 0.0713 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0225 | 0.0782 |
Brugia malayi | intermediate filament protein | 0.0112 | 0.079 | 0.2753 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0127 | 0.0936 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.0433 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0074 | 0.0433 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0108 | 0.075 | 0.2615 |
Loa Loa (eye worm) | intermediate filament protein | 0.0112 | 0.079 | 0.2753 |
Schistosoma mansoni | lamin | 0.0112 | 0.079 | 0.2197 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0265 | 0.2238 | 0.7797 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0332 | 0.287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0433 | 0.151 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0802 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0074 | 0.0433 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.005 | 0.0205 | 0.0713 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0158 | 0.1221 | 0.4253 |
Schistosoma mansoni | tar DNA-binding protein | 0.0332 | 0.287 | 1 |
Brugia malayi | RNA binding protein | 0.0332 | 0.287 | 1 |
Onchocerca volvulus | 0.0074 | 0.0433 | 0.3503 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.0433 | 0.151 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0433 | 0.1032 |
Echinococcus multilocularis | musashi | 0.0112 | 0.079 | 0.0598 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.0433 | 0.151 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0074 | 0.0433 | 0.1032 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.0433 | 0.151 |
Onchocerca volvulus | 0.0112 | 0.079 | 0.6388 | |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.0802 | 0.2241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0332 | 0.287 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0127 | 0.0936 | 1 |
Onchocerca volvulus | 0.0074 | 0.0433 | 0.3503 | |
Brugia malayi | TAR-binding protein | 0.0332 | 0.287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0433 | 0.151 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1237 | 0.431 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1221 | 0.4253 |
Schistosoma mansoni | lamin | 0.0112 | 0.079 | 0.2197 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0158 | 0.1221 | 0.4253 |
Schistosoma mansoni | intermediate filament proteins | 0.0112 | 0.079 | 0.2197 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.079 | 0.2753 |
Echinococcus multilocularis | lamin | 0.0112 | 0.079 | 0.0598 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0074 | 0.0433 | 0.1032 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0074 | 0.0433 | 0.1032 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0433 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0332 | 0.287 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0473 | 0.42 | 1 |
Echinococcus granulosus | lamin | 0.0112 | 0.079 | 0.0598 |
Schistosoma mansoni | tar DNA-binding protein | 0.0332 | 0.287 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0433 | 0.0858 |
Schistosoma mansoni | tar DNA-binding protein | 0.0332 | 0.287 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.0433 | 0.0233 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0433 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0057 | 0.0273 | 0.007 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.0433 | 0.0233 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0112 | 0.079 | 0.2753 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0433 | 0.1032 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0127 | 0.0936 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0433 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0265 | 0.2238 | 0.7797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.