TDR Targets

Basic information

Technical information

TDR Targets ID: 621635
Name: N-[(2,6-dichlorophenyl)methylideneamino]-5-(4 -methoxyphenyl)-2H-pyrazole-3-carboxamide
MW: 389.235 | Formula: C18H14Cl2N4O2
H donors: 2 H acceptors: 2 LogP: 3.66 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1n[nH]c(c1)C(=O)N/N=C/c1c(Cl)cccc1Cl
InChi: 1S/C18H14Cl2N4O2/c1-26-12-7-5-11(6-8-12)16-9-17(23-22-16)18(25)24-21-10-13-14(19)3-2-4-15(13)20/h2-10H,1H3,(H,22,23)(H,24,25)/b21-10+
InChiKey: QBRJOVUMSVMDGH-UFFVCSGVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2,6-dichlorophenyl)methyleneamino]-5-(4-methoxyphenyl)-2H-pyrazole-3-carboxamide
N-[(2,6-dichlorobenzylidene)amino]-5-(4-methoxyphenyl)-2H-pyrazole-3-carboxamide
ST5053767

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0028	0.0103	0.0036
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.021	0.7904
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.021	0.7904
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0028	0.0103	0.0036
Schistosoma mansoni	tar DNA-binding protein	0.0338	0.3692	0.4712
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0028	0.0103	0.0046
Schistosoma mansoni	intermediate filament proteins	0.0085	0.077	0.0913
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.021	0.0185
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0	0.5
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0028	0.0103	0.0045
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0068	0.0575	0.0647
Mycobacterium leprae	Probable lipase LipE	0.0037	0.021	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.021	0.0569
Schistosoma mansoni	microtubule-associated protein tau	0.069	0.776	1
Brugia malayi	hypothetical protein	0.0035	0.0192	0.0329
Schistosoma mansoni	voltage-gated potassium channel	0.0068	0.0575	0.0659
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0633	0.0735
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.0238	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0337	0.035
Trypanosoma cruzi	PAB1-binding protein , putative	0.0055	0.0416	1
Loa Loa (eye worm)	hhat protein	0.0028	0.0103	0.0279
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.021	0.0839
Brugia malayi	Intermediate filament tail domain containing protein	0.0085	0.077	0.1925
Echinococcus granulosus	tar DNA binding protein	0.0338	0.3692	0.4629
Brugia malayi	latrophilin 2 splice variant baaae	0.0103	0.0979	0.2503
Schistosoma mansoni	hypothetical protein	0.0028	0.0103	0.0046
Brugia malayi	beta-lactamase family protein	0.0037	0.021	0.0379
Echinococcus multilocularis	microtubule associated protein 2	0.069	0.776	0.7744
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0972	0.2632
Loa Loa (eye worm)	RNA binding protein	0.0338	0.3692	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0073	0.3062
Leishmania major	glycerol uptake protein, putative	0.0028	0.0103	0.0875
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0238	0.5
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0028	0.0103	0.0045
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0151	0.1532	0.4031
Mycobacterium tuberculosis	Conserved protein	0.0037	0.021	0.0839
Schistosoma mansoni	ap endonuclease	0.0039	0.0238	0.0222
Onchocerca volvulus		0.0037	0.021	0.1525
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.021	0.3416
Mycobacterium tuberculosis	Conserved protein	0.0037	0.021	0.0839
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0633	0.0722
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0337	0.073
Plasmodium vivax	ataxin-2 like protein, putative	0.0055	0.0416	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0633	0.057
Trichomonas vaginalis	esterase, putative	0.0037	0.021	0.7904
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0238	0.2952
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0337	0.0913
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0046	0.0312	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0979	0.2652
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0028	0.0103	0.0036
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.021	0.0839
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.021	0.0182
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0028	0.0103	0.2475
Brugia malayi	hypothetical protein	0.0055	0.0416	0.0948
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0028	0.0103	0.0046
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0039	0.0238	0.0952
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0073	0.0291
Brugia malayi	beta-lactamase family protein	0.0037	0.021	0.0379
Echinococcus multilocularis	tar DNA binding protein	0.0338	0.3692	0.3649
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0151	0.1532	0.415
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0028	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0255	0.273	0.7394
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.021	1
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0028	0.0103	0.0036
Loa Loa (eye worm)	MH2 domain-containing protein	0.0251	0.2687	0.7277
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0028	0.0103	0.0046
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.021	0.881
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0279
Echinococcus granulosus	GPCR family 2	0.0048	0.0337	0.0344
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0338	0.3692	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0416	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0752	0.2036
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0028	0.0103	0.0279
Leishmania major	glycerol uptake protein, putative	0.0028	0.0103	0.0875
Onchocerca volvulus		0.0085	0.077	0.7754
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.021	0.0839
Schistosoma mansoni	tar DNA-binding protein	0.0338	0.3692	0.4712
Onchocerca volvulus		0.0028	0.0103	0.0334
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.021	0.3416
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0238	0.0457
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0028	0.0103	0.0036
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.3062
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0238	1
Loa Loa (eye worm)	intermediate filament protein	0.0085	0.077	0.2085
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0238	0.0218
Onchocerca volvulus		0.0037	0.021	0.1525
Echinococcus granulosus	sterol O acyltransferase 1	0.0283	0.3049	0.3807
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0073	0.3062
Schistosoma mansoni	hypothetical protein	0.0103	0.0979	0.1185
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0238	0.0172
Entamoeba histolytica	vacuolar protein sorting 26	0.0028	0.0103	0.0536
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0238	0.5728
Echinococcus multilocularis	tumor protein p63	0.0702	0.7898	0.7884
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0198
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0028	0.0103	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0283	0.3049	0.8257
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0238	0.0646
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0028	0.0103	0.0279
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0238	0.5728
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0028	0.0103	0.0045
Brugia malayi	intermediate filament protein	0.0085	0.077	0.1925
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0151	0.1532	0.4031
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.021	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0037	0.021	0.0569
Loa Loa (eye worm)	hhat protein	0.0028	0.0103	0.0279
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0073	0.0291
Brugia malayi	MBOAT family protein	0.0028	0.0103	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0037	0.021	0.0569
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0238	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.021	0.7904
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0238	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0073	0.3062
Echinococcus multilocularis	potassium voltage gated channel protein	0.0068	0.0575	0.051
Leishmania major	glycerol uptake protein, putative	0.0028	0.0103	0.0875
Trypanosoma cruzi	PAB1-binding protein , putative	0.0055	0.0416	1
Entamoeba histolytica	hypothetical protein	0.0073	0.0633	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.021	0.0569
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.3062
Loa Loa (eye worm)	hypothetical protein	0.0037	0.021	0.0569
Onchocerca volvulus		0.0037	0.021	0.1525
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0073	0.3062
Brugia malayi	Hhat protein	0.0028	0.0103	0.0083
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0041	0.026	0.0193
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.2505	1
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0028	0.0103	0.0036
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0337	0.0271
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0028	0.0103	0.0045
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0065	0.054	0.0476
Loa Loa (eye worm)	MBOAT family protein	0.0028	0.0103	0.0279
Onchocerca volvulus		0.0103	0.0972	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0238	0.4819
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.021	0.881
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0028	0.0103	0.0046
Schistosoma mansoni	tar DNA-binding protein	0.0338	0.3692	0.4712
Toxoplasma gondii	ABC1 family protein	0.0037	0.021	0.3416
Toxoplasma gondii	exonuclease III APE	0.0039	0.0238	0.4323
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0337	0.0344
Echinococcus multilocularis	sterol O acyltransferase 1	0.0283	0.3049	0.3002
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0238	0.4323
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0028	0.0103	0.0046
Schistosoma mansoni	tar DNA-binding protein	0.0338	0.3692	0.4712
Plasmodium falciparum	ataxin-2 like protein, putative	0.0055	0.0416	1
Entamoeba histolytica	hypothetical protein	0.0073	0.0633	1
Schistosoma mansoni	lamin	0.0085	0.077	0.0913
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0028	0.0103	0.0536
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0068	0.0575	0.1386
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.3062
Loa Loa (eye worm)	transcription factor SMAD2	0.0251	0.2687	0.7277
Brugia malayi	MH2 domain containing protein	0.0251	0.2687	0.7222
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.021	0.7904
Onchocerca volvulus		0.0085	0.077	0.7754
Schistosoma mansoni	ap endonuclease	0.0039	0.0238	0.0222
Entamoeba histolytica	hypothetical protein	0.0028	0.0103	0.0536
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0028	0.0103	0.0536
Loa Loa (eye worm)	MBOAT family protein	0.0028	0.0103	0.0279
Echinococcus granulosus	intermediate filament protein	0.0085	0.077	0.0897
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0028	0.0103	0.0045
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.021	0.3416
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0041	0.026	0.0245
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0028	0.0103	0.0045
Brugia malayi	RNA recognition motif domain containing protein	0.0338	0.3692	1
Mycobacterium ulcerans	lipase LipD	0.0037	0.021	0.881
Schistosoma mansoni	voltage-gated potassium channel	0.0068	0.0575	0.0659
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.021	0.0839
Echinococcus multilocularis	musashi	0.0085	0.077	0.0707
Entamoeba histolytica	hypothetical protein, conserved	0.0028	0.0103	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0198
Mycobacterium ulcerans	hypothetical protein	0.0037	0.021	0.881
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0028	0.0103	0.2475
Schistosoma mansoni	hypothetical protein	0.0048	0.0337	0.035
Leishmania major	hypothetical protein, conserved	0.0055	0.0416	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0073	0.3062
Brugia malayi	RNA binding protein	0.0338	0.3692	1
Leishmania major	glycerol uptake protein, putative	0.0028	0.0103	0.0875
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.021	0.5046
Loa Loa (eye worm)	TAR-binding protein	0.0338	0.3692	1
Schistosoma mansoni	sterol O-acyltransferase 1	0.0283	0.3049	0.3876
Schistosoma mansoni	hypothetical protein	0.0073	0.0633	0.0735
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.021	0.0839
Brugia malayi	MBOAT family protein	0.0028	0.0103	0.0083
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0337	0.0271
Echinococcus granulosus	lamin	0.0085	0.077	0.0897
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.021	0.0185
Echinococcus granulosus	tumor protein p63	0.0702	0.7898	1
Brugia malayi	MBOAT family protein	0.0028	0.0103	0.0083
Entamoeba histolytica	hypothetical protein	0.0073	0.0633	1
Loa Loa (eye worm)	MBOAT family protein	0.0028	0.0103	0.0279
Schistosoma mansoni	hypothetical protein	0.0048	0.0337	0.035
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0028	0.0103	0.0045
Schistosoma mansoni	cellular tumor antigen P53	0.0103	0.0972	0.1175
Schistosoma mansoni	lamin	0.0085	0.077	0.0913
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.021	0.0569
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.021	0.0143
Plasmodium falciparum	ataxin-2 like protein, putative	0.0055	0.0416	1
Echinococcus granulosus	lamin dm0	0.0085	0.077	0.0897
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0028	0.0103	0.0036
Brugia malayi	MBOAT family protein	0.0028	0.0103	0.0083
Entamoeba histolytica	hypothetical protein	0.0073	0.0633	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.021	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0337	0.0913
Loa Loa (eye worm)	hypothetical protein	0.004	0.0242	0.0655
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.021	0.0839
Mycobacterium ulcerans	beta-lactamase	0.0037	0.021	0.881
Loa Loa (eye worm)	hypothetical protein	0.004	0.0242	0.0655
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0028	0.0103	0.0536
Trypanosoma brucei	PAB1-binding protein , putative	0.0055	0.0416	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0028	0.0103	0.0036
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0238	0.5
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0238	0.4323
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0279
Brugia malayi	hypothetical protein	0.0073	0.0633	0.1548
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.021	0.7904
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0337	0.0344
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0238	0.4323
Brugia malayi	beta-lactamase	0.0037	0.021	0.0379
Leishmania major	glycerol uptake protein, putative	0.0028	0.0103	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0085	0.077	0.2085
Brugia malayi	TAR-binding protein	0.0338	0.3692	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0337	0.035
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1532	0.415
Leishmania major	hypothetical protein, conserved	0.0037	0.021	0.3992
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.021	0.0839
Loa Loa (eye worm)	beta-lactamase	0.0037	0.021	0.0569
Schistosoma mansoni	zinc finger protein	0.0028	0.0103	0.0046
Mycobacterium tuberculosis	Conserved protein	0.0037	0.021	0.0839
Brugia malayi	MBOAT family protein	0.0028	0.0103	0.0083
Brugia malayi	cytoplasmic intermediate filament protein	0.0046	0.0312	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0575	0.1556
Echinococcus multilocularis	lamin	0.0085	0.077	0.0707
Brugia malayi	diacylglycerol acyltransferase	0.0028	0.0103	0.0083
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0337	0.073
Toxoplasma gondii	LsmAD domain-containing protein	0.0055	0.0416	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.026	0.0704
Echinococcus granulosus	potassium voltage gated channel protein	0.0068	0.0575	0.0647
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0085	0.077	0.2085
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0279
Echinococcus multilocularis	lamin dm0	0.0085	0.077	0.0707
Echinococcus granulosus	microtubule associated protein 2	0.069	0.776	0.9823
Leishmania major	hypothetical protein, conserved	0.0028	0.0103	0.0875
Schistosoma mansoni	tar DNA-binding protein	0.0338	0.3692	0.4712
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0337	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0198

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 621635