Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0382 | 0.3382 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0077 | 0.0499 | 1 |
Onchocerca volvulus | 0.0135 | 0.1044 | 0.8248 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0754 | 0.2229 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0065 | 0.0384 | 0.0306 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0103 | 0.0738 | 1 |
Onchocerca volvulus | 0.0135 | 0.1044 | 0.8248 | |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0077 | 0.0499 | 0.1124 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0499 | 0.1475 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0499 | 0.1268 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0103 | 0.0738 | 1 |
Schistosoma mansoni | lamin | 0.0135 | 0.1044 | 0.2919 |
Schistosoma mansoni | tar DNA-binding protein | 0.0382 | 0.3382 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0203 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0499 | 0.1475 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0103 | 0.0738 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.008 | 0.0236 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0114 | 0.0847 | 0.2324 |
Mycobacterium ulcerans | lipase LipD | 0.0077 | 0.0499 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0114 | 0.0847 | 0.0774 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.0754 | 0.2229 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0499 | 0.1124 |
Brugia malayi | RNA binding protein | 0.0382 | 0.3382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.036 | 0.1066 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0499 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0077 | 0.0499 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0499 | 0.1124 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0135 | 0.1044 | 0.3087 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0499 | 0.1475 |
Schistosoma mansoni | tar DNA-binding protein | 0.0382 | 0.3382 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.0754 | 0.2229 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.0499 | 1 |
Onchocerca volvulus | 0.0077 | 0.0499 | 0.3941 | |
Brugia malayi | MH2 domain containing protein | 0.0245 | 0.2087 | 0.617 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0847 | 0.2324 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1044 | 0.3087 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0499 | 0.1475 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.0499 | 0.6757 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0384 | 0.1135 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0382 | 0.3382 | 1 |
Brugia malayi | beta-lactamase | 0.0077 | 0.0499 | 0.1475 |
Echinococcus multilocularis | musashi | 0.0135 | 0.1044 | 0.0972 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0847 | 0.2506 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0077 | 0.0499 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0499 | 0.1475 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0103 | 0.0738 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0135 | 0.1044 | 0.3087 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0077 | 0.0499 | 0.1124 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0442 | 0.1096 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0077 | 0.0499 | 0.1124 |
Loa Loa (eye worm) | intermediate filament protein | 0.0135 | 0.1044 | 0.3087 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0077 | 0.0499 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.036 | 0.1066 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0077 | 0.0499 | 0.0422 |
Echinococcus granulosus | lamin | 0.0135 | 0.1044 | 0.0972 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0245 | 0.2087 | 0.617 |
Loa Loa (eye worm) | RNA binding protein | 0.0382 | 0.3382 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0499 | 0.1124 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0738 | 0.2183 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0077 | 0.0499 | 0.1124 |
Onchocerca volvulus | 0.0077 | 0.0499 | 0.3941 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0382 | 0.3382 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0499 | 0.1268 |
Echinococcus granulosus | lamin dm0 | 0.0135 | 0.1044 | 0.0972 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0158 | 0.1266 | 0.3591 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0072 | 0.0451 | 0.1335 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0077 | 0.0499 | 0.1475 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0499 | 0.1475 |
Echinococcus multilocularis | lamin | 0.0135 | 0.1044 | 0.0972 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0499 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0072 | 0.0451 | 0.1335 |
Echinococcus granulosus | intermediate filament protein | 0.0135 | 0.1044 | 0.0972 |
Onchocerca volvulus | 0.0077 | 0.0499 | 0.3941 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.008 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0738 | 0.2183 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0493 | 0.4437 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0847 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0382 | 0.3382 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0499 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0135 | 0.1044 | 0.2919 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.0754 | 0.2229 |
Loa Loa (eye worm) | beta-lactamase | 0.0077 | 0.0499 | 0.1475 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0442 | 0.1307 |
Schistosoma mansoni | tar DNA-binding protein | 0.0382 | 0.3382 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0847 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0245 | 0.2087 | 0.617 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0046 | 0.0203 | 0.0124 |
Schistosoma mansoni | lamin | 0.0135 | 0.1044 | 0.2919 |
Echinococcus multilocularis | lamin dm0 | 0.0135 | 0.1044 | 0.0972 |
Brugia malayi | intermediate filament protein | 0.0135 | 0.1044 | 0.3087 |
Onchocerca volvulus | 0.0158 | 0.1266 | 1 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0103 | 0.0738 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0499 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0077 | 0.0499 | 0.1124 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0077 | 0.0499 | 0.1124 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0103 | 0.0738 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0103 | 0.0738 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0847 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.008 | 0.0236 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0114 | 0.0847 | 0.0774 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1266 | 0.3742 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0077 | 0.0499 | 0.1475 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0442 | 0.1307 |
Mycobacterium leprae | Probable lipase LipE | 0.0077 | 0.0499 | 1 |
Brugia malayi | TAR-binding protein | 0.0382 | 0.3382 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0382 | 0.3382 | 0.3329 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1021 | 0.3018 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0065 | 0.0384 | 0.0306 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0077 | 0.0499 | 0.0422 |
Trichomonas vaginalis | esterase, putative | 0.0077 | 0.0499 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0077 | 0.0499 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0394 | 0.1166 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0499 | 0.1475 |
Leishmania major | hypothetical protein, conserved | 0.0103 | 0.0738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.008 | 0.0236 |
Schistosoma mansoni | tar DNA-binding protein | 0.0382 | 0.3382 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0499 | 0.5 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0046 | 0.0203 | 0.0124 |
Echinococcus granulosus | tar DNA binding protein | 0.0382 | 0.3382 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0499 | 0.1475 |
Echinococcus multilocularis | tumor protein p63 | 0.1081 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.