Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0198 | 1 |
Brugia malayi | intermediate filament protein | 0.0083 | 0.088 | 0.1608 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0198 | 0.0599 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0725 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0198 | 0.0366 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0725 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0198 | 0.035 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0198 | 0.035 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0044 | 0.0307 | 0.0551 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0198 | 0.0599 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0198 | 0.035 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0435 | 0.0787 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.0725 | 0.0725 |
Loa Loa (eye worm) | TAR-binding protein | 0.0388 | 0.5428 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0198 | 0.5 |
Onchocerca volvulus | 0.0083 | 0.088 | 0.7559 | |
Echinococcus multilocularis | musashi | 0.0083 | 0.088 | 0.088 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.0725 | 0.1335 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.1153 | 0.2112 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0123 | 0.0226 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0123 | 0.0211 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0198 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.1153 | 0.2112 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0725 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.088 | 0.1608 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0435 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0435 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0198 | 0.0599 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0248 | 0.3351 | 0.6167 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0198 | 0.0599 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0198 | 0.035 |
Schistosoma mansoni | lamin | 0.0083 | 0.088 | 0.1621 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0198 | 0.035 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.0676 | 0.1232 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0725 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0198 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0198 | 0.0599 |
Echinococcus granulosus | intermediate filament protein | 0.0083 | 0.088 | 0.088 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0435 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0123 | 0.0226 |
Echinococcus granulosus | tar DNA binding protein | 0.0388 | 0.5428 | 0.5428 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0123 | 0.0123 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0198 | 0.0366 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0198 | 0.035 |
Onchocerca volvulus | 0.0037 | 0.0198 | 0.1647 | |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0198 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0198 | 0.035 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0198 | 0.0198 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0198 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0248 | 0.3351 | 0.6167 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.004 | 0.0242 | 0.0242 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.3176 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0044 | 0.0307 | 0.0551 |
Loa Loa (eye worm) | intermediate filament protein | 0.0083 | 0.088 | 0.1608 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0725 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0694 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0198 | 0.035 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0198 | 0.0599 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0123 | 0.0226 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0123 | 0.0211 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0388 | 0.5428 | 1 |
Brugia malayi | RNA binding protein | 0.0388 | 0.5428 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0248 | 0.3351 | 0.6167 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0123 | 0.0211 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.004 | 0.0242 | 0.0242 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0435 | 0.5 |
Onchocerca volvulus | 0.0083 | 0.088 | 0.7559 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0198 | 0.0599 |
Schistosoma mansoni | lamin | 0.0083 | 0.088 | 0.1621 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0198 | 0.0599 |
Brugia malayi | TAR-binding protein | 0.0388 | 0.5428 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0388 | 0.5428 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0083 | 0.088 | 0.1608 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0676 | 0.1246 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0123 | 0.0226 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0388 | 0.5428 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0676 | 0.1232 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0435 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0083 | 0.088 | 0.1608 |
Schistosoma mansoni | tar DNA-binding protein | 0.0388 | 0.5428 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0198 | 0.445 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0857 | 0.1566 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0198 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0725 | 0.1335 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0219 | 0.0388 |
Onchocerca volvulus | 0.0037 | 0.0198 | 0.1647 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.0725 | 0.0725 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0219 | 0.0388 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0198 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0156 | 0.0271 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0435 | 1 |
Onchocerca volvulus | 0.0102 | 0.1161 | 1 | |
Echinococcus granulosus | lamin | 0.0083 | 0.088 | 0.088 |
Schistosoma mansoni | intermediate filament proteins | 0.0083 | 0.088 | 0.1621 |
Echinococcus granulosus | lamin dm0 | 0.0083 | 0.088 | 0.088 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0435 | 1 |
Onchocerca volvulus | 0.0037 | 0.0198 | 0.1647 | |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0198 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0435 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0388 | 0.5428 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0198 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0198 | 0.0599 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1161 | 0.2127 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0198 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0123 | 0.0211 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0198 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0198 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0198 | 0.035 |
Echinococcus multilocularis | tar DNA binding protein | 0.0388 | 0.5428 | 0.5428 |
Schistosoma mansoni | tar DNA-binding protein | 0.0388 | 0.5428 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0388 | 0.5428 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0388 | 0.5428 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.1153 | 0.2112 |
Echinococcus multilocularis | lamin dm0 | 0.0083 | 0.088 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0242 | 0.043 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0198 | 0.035 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0198 | 0.0599 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0198 | 0.035 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0435 | 0.0787 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1153 | 0.2112 |
Echinococcus multilocularis | lamin | 0.0083 | 0.088 | 0.088 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0123 | 0.0123 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0102 | 0.1161 | 0.214 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0123 | 0.0123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.