Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0089 | 0.2345 | 0.8795 |
Mycobacterium tuberculosis | Probable reductase | 0.0089 | 0.2345 | 0.8795 |
Echinococcus multilocularis | lamin | 0.0107 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.2859 | 0.3326 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0089 | 0.2345 | 0.8795 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0727 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0238 | 0.7137 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0089 | 0.2345 | 0.8795 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.0727 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0052 | 0.1134 | 0.1134 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.2666 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1007 | 0.0436 |
Echinococcus granulosus | lamin | 0.0107 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | intermediate filament protein | 0.0107 | 0.2923 | 0.3425 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.0744 | 0.0744 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.2666 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0107 | 0.2923 | 0.2923 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.0727 | 0.5 |
Onchocerca volvulus | 0.0107 | 0.2923 | 1 | |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.0727 | 0.2728 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0058 | 0.1317 | 0.092 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.2666 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0089 | 0.2345 | 0.8795 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0727 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2923 | 0.3425 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.1007 | 0.287 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0107 | 0.2923 | 0.8331 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0089 | 0.2345 | 0.8795 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0107 | 0.2923 | 0.3425 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.107 | 0.0535 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.0727 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.0727 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0107 | 0.2923 | 0.3425 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0727 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0107 | 0.2923 | 0.8331 |
Echinococcus multilocularis | musashi | 0.0107 | 0.2923 | 0.2923 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0058 | 0.1317 | 0.092 |
Echinococcus granulosus | intermediate filament protein | 0.0107 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.107 | 0.0535 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0052 | 0.1134 | 0.1134 |
Onchocerca volvulus | 0.0107 | 0.2923 | 1 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.0744 | 0.0744 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0727 | 0.5 |
Trichomonas vaginalis | ferritin, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1134 | 0.0634 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0089 | 0.2345 | 0.8795 |
Brugia malayi | MH2 domain containing protein | 0.0238 | 0.7137 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.2666 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0017 | 0 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0107 | 0.2923 | 0.3425 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0238 | 0.7137 | 1 |
Schistosoma mansoni | lamin | 0.0107 | 0.2923 | 0.8331 |
Echinococcus granulosus | lamin dm0 | 0.0107 | 0.2923 | 0.2923 |
Echinococcus multilocularis | tumor protein p63 | 0.0327 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.