TDR Targets

Basic information

Technical information

TDR Targets ID: 621870
Name: 3-(4-ethoxyphenyl)-2-[2-(2-ethylpiperidin-1-y l)-2-oxoethyl]sulfanyl-6,7-dihydrothieno[2,3- e]pyrimidin-4-one
MW: 459.625 | Formula: C23H29N3O3S2
H donors: 0 H acceptors: 2 LogP: 4.39 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)n1c(SCC(=O)N2CCCCC2CC)nc2c(c1=O)SCC2
InChi: 1S/C23H29N3O3S2/c1-3-16-7-5-6-13-25(16)20(27)15-31-23-24-19-12-14-30-21(19)22(28)26(23)17-8-10-18(11-9-17)29-4-2/h8-11,16H,3-7,12-15H2,1-2H3
InChiKey: JHRVBIKCQUKNSW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-(4-ethoxyphenyl)-2-[2-(2-ethyl-1-piperidyl)-2-oxo-ethyl]sulfanyl-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
3-(4-ethoxyphenyl)-2-[[2-(2-ethyl-1-piperidinyl)-2-oxoethyl]thio]-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
3-(4-ethoxyphenyl)-2-[[2-(2-ethyl-1-piperidyl)-2-keto-ethyl]thio]-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
3-(4-ethoxyphenyl)-2-[2-(2-ethylpiperidin-1-yl)-2-oxo-ethyl]sulfanyl-6,7-dihydrothieno[2,3-e]pyrimidin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0322	0.9176	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.3489	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0021	0.0464	0.0098
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0678	0.0739
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0138	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0138	0.0151
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0708
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0138	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0138	0.0151
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0576	0.0128
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0126	0.3489	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0138	0.0138
Schistosoma mansoni	hypothetical protein	0.0011	0.0173	0.0173
Onchocerca volvulus		0.0029	0.0678	0.2973
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0138	0.0138
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0073	0.1953	0.1709
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0138	0.0708
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0708
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0021	0.0464	0.0464
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0464	0.2376
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0138	0.0138
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0138	0.0138
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0073	0.1953	0.4924
Echinococcus granulosus	cpg binding protein	0.003	0.0725	0.0725
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0126	0.3489	0.3489
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0322	0.9176	1
Schistosoma mansoni	hypothetical protein	0.035	1	1
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0021	0.0464	0.0098
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0464	0.0506
Leishmania major	hypothetical protein, conserved	0.0025	0.0576	0.0128
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0464	0.0098
Schistosoma mansoni	acetyl-CoA synthetase	0.0021	0.0464	0.0464
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0138	0.0138
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0138	0.0151
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.1953	0.2129
Brugia malayi	hypothetical protein	0.0025	0.0576	0.0628
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.1334	0.1087
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0138	0.0138
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0138	0.0138
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.1953	0.1709
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0126	0.3489	0.3489
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0138	0.0138
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.01	0.0108
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0073	0.1953	0.1709
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0021	0.0464	0.0098
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0708
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.1953	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0464	0.2376
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0576	0.0128
Echinococcus multilocularis	cpg binding protein	0.003	0.0725	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1421	0.7272
Onchocerca volvulus		0.0021	0.0464	0.1796
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0138	0.0151
Schistosoma mansoni	cpg binding protein	0.0029	0.0678	0.0678
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0464	0.0098
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0021	0.0464	0.0506
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0073	0.1953	0.1709
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0678	0.3471
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0052	0.0052
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.1334	0.1087
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0322	0.9176	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0138	0.0138
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0464	0.1246
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.3489	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0464	0.1246
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1953	1
Schistosoma mansoni	coup transcription factor	0.001	0.0138	0.0138
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0054	0.1421	0.1185
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0138	0.0151
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0052	0.0052
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0021	0.0464	0.0464
Brugia malayi	hypothetical protein	0.0016	0.0317	0.0346
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.1423	0.1101
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0073	0.1953	0.4924
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0464	0.0506
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0073	0.1953	0.1709
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0138	0.0151
Schistosoma mansoni	cpg binding protein	0.003	0.0725	0.0725
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0138	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0138	0.0151
Brugia malayi	steroid hormone receptor	0.001	0.0138	0.0151
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0138	0.0138
Leishmania major	dihydroorotate dehydrogenase	0.0322	0.9176	1
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0138	0.0151
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.1953	0.1709
Plasmodium vivax	acyl-CoA synthetase, putative	0.0054	0.1421	0.1098
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0054	0.1421	0.1098
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.0464	0.0506
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1421	0.7272
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0138	0.0151
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0138	0.0138
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0126	0.3489	0.3489
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0138	0.0151
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0708
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0576	0.0128
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0464	0.0506
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1612	0.1612
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0021	0.0464	0.0098
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0322	0.9176	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0138	0.0138
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0138	0.0151
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0322	0.9176	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0138	0.0708
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0138	0.0708
Onchocerca volvulus		0.0073	0.1953	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0138	0.0708
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0464	0.0506
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0138	0.0138
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0322	0.9176	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.1953	0.1709
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0073	0.1953	0.1709
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0322	0.9176	0.5
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.1334	0.1087
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0126	0.3489	0.3472
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0138	0.0708
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0322	0.9176	1
Plasmodium falciparum	acyl-CoA synthetase	0.0054	0.1421	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1953	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0138	0.0138
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0138	0.0138
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0138	0.0138
Mycobacterium ulcerans	hypothetical protein	0.0073	0.1953	0.1709
Brugia malayi	nuclear receptor NHR-88	0.001	0.0138	0.0151
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0052	0.0052
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0576	0.0128
Onchocerca volvulus		0.0021	0.0464	0.1796
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0103	0.0103
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0103	0.0103
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0322	0.9176	0.9176
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0138	0.0708
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0464	0.0098
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1953	1
Brugia malayi	nuclear hormone receptor	0.001	0.0138	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1421	0.7272
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0464	0.2376
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0073	0.1953	0.1791
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0138	0.0138
Entamoeba histolytica	acyl-coA synthetase, putative	0.0073	0.1953	0.4924
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.3489	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0138	0.0138
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0021	0.0464	0.0098
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0708
Brugia malayi	ecdysteroid receptor	0.001	0.0138	0.0151
Echinococcus multilocularis	geminin	0.035	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0138	0.0151
Loa Loa (eye worm)	oxidoreductase	0.0021	0.0464	0.2376
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0322	0.9176	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0073	0.1953	0.1709
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0054	0.1421	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0576	0.2949
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0138	0.0138
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0073	0.1953	0.1791
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0138	0.0151
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0138	0.0708
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0138	0.0138
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0103	0.0526
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0021	0.0464	0.0098
Schistosoma mansoni	cpg binding protein	0.003	0.0725	0.0725
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0576	0.0128
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0126	0.3489	0.3489
Onchocerca volvulus		0.0021	0.0464	0.1796
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0138	0.0138
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0138	0.0708
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0576	0.0128
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.3489	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0138	0.0138
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0138	0.0138
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0322	0.9176	1
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0322	0.9176	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0138	0.0138
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.1334	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1421	0.7272
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.1953	0.1709
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1421	0.7272
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.035	1	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.3489	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0052	0.0052
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0126	0.3489	1
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0138	0.0138
Brugia malayi	Zinc finger, C2H2 type family protein	0.0126	0.3489	0.3802
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0322	0.9176	1
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0464	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0464	0.2376
Onchocerca volvulus		0.0021	0.0464	0.1796
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0464	0.0098
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0138	0.0138
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.1953	0.1709
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0322	0.9176	1
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.1953	0.2129
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.1953	0.2129
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0576	0.0128

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 621870