Detailed information for compound 622466

Basic information

Technical information
  • TDR Targets ID: 622466
  • Name: [2-[(2-chloro-6-fluorophenyl)methylsulfanyl]- 4,5-dihydroimidazol-1-yl]-(4-methylphenyl)met hanone
  • MW: 362.849 | Formula: C18H16ClFN2OS
  • H donors: 0 H acceptors: 1 LogP: 4.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C(=O)N1CCN=C1SCc1c(F)cccc1Cl
  • InChi: 1S/C18H16ClFN2OS/c1-12-5-7-13(8-6-12)17(23)22-10-9-21-18(22)24-11-14-15(19)3-2-4-16(14)20/h2-8H,9-11H2,1H3
  • InChiKey: QQCWYEYXVDUHEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[(2-chloro-6-fluoro-phenyl)methylsulfanyl]-4,5-dihydroimidazol-1-yl]-(4-methylphenyl)methanone
  • [2-[(2-chloro-6-fluorophenyl)methylthio]-4,5-dihydroimidazol-1-yl]-(4-methylphenyl)methanone
  • [2-[(2-chloro-6-fluoro-benzyl)thio]-4,5-dihydroimidazol-1-yl]-(4-methylphenyl)methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0012 0.0019
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0086 0.0098
Schistosoma mansoni dishevelled 0.0009 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0086 0.0098
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.004 0.0045
Brugia malayi MH2 domain containing protein 0.0117 0.4224 0.4791
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.328 0.536
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1436 0.1628
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.4224 0.4791
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.082 0.2501
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.082 0.134
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.019 0.7055 0.8958
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0086 0.0098
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.082 0.1042
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.2926 1
Onchocerca volvulus 0.0236 0.8816 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.004 0.0065
Echinococcus multilocularis GPCR, family 2 0.0031 0.0898 0.1467
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0086 0.0141
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0045
Loa Loa (eye worm) hypothetical protein 0.0177 0.6539 0.7417
Entamoeba histolytica hypothetical protein 0.0035 0.1066 0.3249
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.328 1
Schistosoma mansoni kinase 0.0047 0.1521 0.1521
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0086 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0086 0.0098
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0524 0.0594
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.082 0.2501
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0012 0.0013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0898 0.1467
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.082 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0086 0.0098
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.082 0.2501
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.082 0.2501
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.004 0.0065
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.082 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.2945 0.4813
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.2945 0.4813
Schistosoma mansoni nuclear hormone receptor 0.001 0.0086 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.082 0.2501
Schistosoma mansoni hypothetical protein 0.0035 0.1066 0.1066
Mycobacterium tuberculosis Probable reductase 0.019 0.7055 0.8958
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.328 1
Echinococcus granulosus GPCR family 2 0.0031 0.0898 0.1467
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1436 0.1436
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1474 0.4494
Schistosoma mansoni dep domain containing protein 0.0009 0.004 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.328 1
Brugia malayi MH2 domain containing protein 0.0008 0.0012 0.0013
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.004 0.004
Schistosoma mansoni thyroid hormone receptor 0.001 0.0086 0.0086
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0086 0.0098
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0086 0.0086
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0898 0.1467
Mycobacterium tuberculosis Probable dehydrogenase 0.019 0.7055 0.8958
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0086 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0086 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0086 0.0098
Plasmodium falciparum thioredoxin reductase 0.0084 0.2926 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0086 0.0141
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.082 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0212 0.7875 1
Schistosoma mansoni hypothetical protein 0.0166 0.6119 0.6119
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.019 0.7055 0.8958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0086 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0086 0.0098
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.328 0.3721
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0086 0.0098
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.004 0.0045
Treponema pallidum NADH oxidase 0.0029 0.082 1
Brugia malayi Thioredoxin reductase 0.0084 0.2926 0.3319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0086 0.0098
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1436 0.1436
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.328 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.6539 0.7417
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0098
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0086 0.0098
Loa Loa (eye worm) Smad1 0.0008 0.0012 0.0013
Brugia malayi hypothetical protein 0.0035 0.1066 0.1209
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.004 0.0065
Loa Loa (eye worm) glutathione reductase 0.0084 0.2926 0.3319
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.3479 0.3946
Brugia malayi steroid hormone receptor 0.001 0.0086 0.0098
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.004 0.0065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.082 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0086 0.0141
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0086 0.0086
Giardia lamblia Kinase, PLK 0.0093 0.328 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0086 0.0098
Echinococcus multilocularis Smad4 0.0008 0.0012 0.0019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0012 0.0019
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0098
Schistosoma mansoni thyroid hormone receptor 0.001 0.0086 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.328 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.082 0.2501
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.004 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.328 0.328
Plasmodium vivax glutathione reductase, putative 0.0084 0.2926 1
Toxoplasma gondii hypothetical protein 0.0009 0.004 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.082 0.2501
Plasmodium falciparum glutathione reductase 0.0029 0.082 0.2803
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1436 0.2346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0898 0.1019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0898 0.1467
Brugia malayi DIX domain containing protein 0.0009 0.004 0.0045
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.082 0.2501
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.004 0.0045
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.082 0.2803
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0086 0.0141
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.2926 0.3716
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.004 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0086 0.0098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.082 0.2501
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0086 0.0098
Toxoplasma gondii thioredoxin reductase 0.0084 0.2926 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.004 0.0065
Schistosoma mansoni smad 0.0008 0.0012 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.082 0.2803
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.328 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0086 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.3479 0.3946
Leishmania major trypanothione reductase 0.0084 0.2926 0.8921
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0086 0.0141
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0086 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1436 0.1436
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.019 0.7055 0.8958
Entamoeba histolytica hypothetical protein 0.0035 0.1066 0.3249
Brugia malayi MH1 domain containing protein 0.0008 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0098
Brugia malayi nuclear receptor NHR-88 0.001 0.0086 0.0098
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.2926 0.8921
Brugia malayi nuclear hormone receptor 0.001 0.0086 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0086 0.0098
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.2926 0.3319
Schistosoma mansoni hypothetical protein 0.0166 0.6119 0.6119
Mycobacterium tuberculosis Probable oxidoreductase 0.0212 0.7875 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0086 0.0141
Schistosoma mansoni hypothetical protein 0.0031 0.0898 0.0898
Brugia malayi ecdysteroid receptor 0.001 0.0086 0.0098
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.004 0.0065
Schistosoma mansoni hypothetical protein 0.0031 0.0898 0.0898
Brugia malayi N-terminal motif family protein 0.0177 0.6539 0.7417
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0086 0.0086
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.082 0.2501
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0086 0.0141
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0012 0.0019
Schistosoma mansoni hypothetical protein 0.0067 0.2284 0.2284
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0086 0.0141
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0086 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1436 0.2346
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0086 0.0098
Entamoeba histolytica hypothetical protein 0.0035 0.1066 0.3249
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.082 0.134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0086 0.0141
Echinococcus granulosus Smad4 0.0008 0.0012 0.0019
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.328 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0524 0.0594
Brugia malayi MH2 domain containing protein 0.0008 0.0012 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0898 0.1019
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.328 1
Brugia malayi hypothetical protein 0.0009 0.004 0.0045
Onchocerca volvulus 0.0009 0.004 0.0045
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0212 0.7875 1
Brugia malayi hypothetical protein 0.0009 0.004 0.0045
Schistosoma mansoni hypothetical protein 0.0031 0.0898 0.0898
Echinococcus granulosus smad 0.0008 0.0012 0.0019
Entamoeba histolytica hypothetical protein 0.0035 0.1066 0.3249
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0898 0.1019
Echinococcus multilocularis smad 0.0008 0.0012 0.0019
Trypanosoma brucei polo-like protein kinase 0.0093 0.328 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.2284 0.2591
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0012 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.082 0.2501
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.328 1
Brugia malayi glutathione reductase 0.0084 0.2926 0.3319
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.082 1
Plasmodium falciparum glutathione reductase 0.0084 0.2926 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.1066 0.1742
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.1066 0.1066
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.328 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.082 0.2501
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.082 0.2803
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.328 0.536
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.328 0.3721
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.082 0.2501
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.004 0.0065
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.082 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.004 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.1066 0.1742
Loa Loa (eye worm) hypothetical protein 0.0031 0.0898 0.1019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0086 0.0141
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1474 0.4494
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0086 0.0098
Brugia malayi Pax transcription factor protein 2 0.0236 0.8816 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.082 0.2501
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0086 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0098
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0086 0.0141
Echinococcus granulosus FTZ F1 alpha 0.001 0.0086 0.0141
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.019 0.7055 0.8958
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0086 0.0086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0212 0.7875 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1436 0.2346
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.004 0.0065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.082 0.2501
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0086 0.0141
Trypanosoma brucei trypanothione reductase 0.0084 0.2926 0.8921
Onchocerca volvulus 0.001 0.0086 0.0098
Schistosoma mansoni regulator of G protein signaling 0.0009 0.004 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.4224 0.4791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0086 0.0098
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0098
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0086 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1436 0.2346
Loa Loa (eye worm) hypothetical protein 0.0098 0.3479 0.3946
Mycobacterium tuberculosis Putative ferredoxin reductase 0.019 0.7055 0.8958
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0086 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0086 0.0098
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0898 0.1467
Schistosoma mansoni hypothetical protein 0.0031 0.0898 0.0898
Plasmodium falciparum thioredoxin reductase 0.0029 0.082 0.2803
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0086 0.0098
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.082 0.2501
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.082 0.082
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.082 0.2803
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.328 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0086 0.0098
Echinococcus multilocularis geminin 0.0166 0.6119 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.004 0.0065
Loa Loa (eye worm) pax transcription factor protein 2 0.0236 0.8816 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0086 0.0098
Brugia malayi MH1 domain containing protein 0.0008 0.0012 0.0013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.082 0.2501
Echinococcus granulosus geminin 0.0166 0.6119 1
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.004 0.0065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.082 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0086 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.082 0.2501
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.082 0.2501
Brugia malayi Smad1 0.0008 0.0012 0.0013
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.082 0.093
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.328 0.3721
Schistosoma mansoni coup transcription factor 0.001 0.0086 0.0086
Schistosoma mansoni dishevelled 0.0009 0.004 0.004
Schistosoma mansoni Smad4 0.0008 0.0012 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0086 0.0098
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.3479 0.3946
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0086 0.0141
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0012 0.0019
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.082 0.2803
Loa Loa (eye worm) hypothetical protein 0.0067 0.2284 0.2591
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1436 0.1628
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.082 0.2501
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0012 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0086 0.0086

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.