Detailed information for compound 622612

Basic information

Technical information
  • TDR Targets ID: 622612
  • Name: 4-[2-[(4-chlorophenyl)methylsulfanyl]4,5-dihy droimidazole-1-carbonyl]-N,N-diethylbenzenesu lfonamide
  • MW: 466.017 | Formula: C21H24ClN3O3S2
  • H donors: 0 H acceptors: 3 LogP: 3.79 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)C(=O)N1CCN=C1SCc1ccc(cc1)Cl)CC
  • InChi: 1S/C21H24ClN3O3S2/c1-3-24(4-2)30(27,28)19-11-7-17(8-12-19)20(26)25-14-13-23-21(25)29-15-16-5-9-18(22)10-6-16/h5-12H,3-4,13-15H2,1-2H3
  • InChiKey: KYBRIOXWJQJMOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[(4-chlorophenyl)methylsulfanyl]4,5-dihydroimidazole-1-carbonyl]-N,N-diethyl-benzenesulfonamide
  • 4-[[2-[(4-chlorophenyl)methylthio]-4,5-dihydroimidazol-1-yl]-oxomethyl]-N,N-diethylbenzenesulfonamide
  • 4-[2-[(4-chlorobenzyl)thio]4,5-dihydroimidazole-1-carbonyl]-N,N-diethyl-benzenesulfonamide
  • 4-[[2-[(4-chlorophenyl)methylsulfanyl]-4,5-dihydroimidazol-1-yl]carbonyl]-N,N-diethyl-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0168 0.3014 0.3716
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0015 0.0125 0.0201
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0015 0.0125 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0935 0.2501
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0383 0.7091 0.8958
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0058 0.0935 0.2803
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0024 0.0038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.038 0.0615
Brugia malayi steroid hormone receptor 0.001 0.0024 0.0054
Plasmodium falciparum glutathione reductase 0.0168 0.3014 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0024 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0702 0.1592
Brugia malayi N-terminal motif family protein 0.0181 0.3265 0.7406
Schistosoma mansoni disulfide oxidoreductase 0.0015 0.0125 0.0124
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0136 0.0219
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0054
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0186 0.3364 0.763
Loa Loa (eye worm) Smad1 0.0016 0.0136 0.0308
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0015 0.0125 0.0201
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0058 0.0935 0.2501
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0024 0.0038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0432 0.0979
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0024 0.0054
Echinococcus multilocularis geminin 0.0335 0.6168 1
Brugia malayi MH2 domain containing protein 0.0016 0.0136 0.0308
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0058 0.0935 0.212
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0432 0.0699
Toxoplasma gondii selenide, water dikinase 0.0015 0.0125 0.0411
Echinococcus granulosus thioredoxin glutathione reductase 0.0169 0.3033 0.4917
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.038 0.0615
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0136 0.0308
Schistosoma mansoni nuclear hormone receptor 0.001 0.0024 0.0023
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0024 0.0023
Brugia malayi glutathione reductase 0.0168 0.3014 0.6837
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.4296 0.9744
Mycobacterium tuberculosis Probable dehydrogenase 0.0383 0.7091 0.8958
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.038 0.038
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0058 0.0935 1
Plasmodium falciparum glutathione reductase 0.0058 0.0935 0.2803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0125 0.0282
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0024 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0432 0.0699
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.3364 0.7979
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0058 0.0935 0.2803
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0001 0.0002
Trypanosoma brucei polo-like protein kinase 0.0186 0.3364 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0024 0.0054
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0136 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0024 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0024 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1728 0.3919
Schistosoma mansoni smad1 5 8 and 0.0016 0.0136 0.0135
Schistosoma mansoni smad1 5 8 and 0.0016 0.0136 0.0135
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0432 0.0979
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0058 0.0935 0.3099
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0024 0.0023
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0516 0.0515
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.3364 0.7979
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0024 0.0054
Brugia malayi Thioredoxin reductase 0.0168 0.3014 0.6837
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0015 0.0125 0.0201
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0426 0.7901 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0024 0.0038
Giardia lamblia NADH oxidase lateral transfer candidate 0.0058 0.0935 0.2501
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0024 0.0054
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0058 0.0935 0.1042
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0058 0.0935 0.1514
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0024 0.0038
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0186 0.3364 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1728 0.3919
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0058 0.0935 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.158 0.3586
Schistosoma mansoni Smad4 0.0016 0.0136 0.0135
Echinococcus granulosus Smad4 0.0016 0.0136 0.0219
Mycobacterium tuberculosis Probable oxidoreductase 0.0426 0.7901 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0516 0.0835
Schistosoma mansoni smad 0.0016 0.0136 0.0135
Schistosoma mansoni sulfide quinone reductase 0.0015 0.0125 0.0124
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0054
Brugia malayi Smad1 0.0016 0.0136 0.0308
Echinococcus multilocularis smad 0.0016 0.0136 0.0219
Brugia malayi MH1 domain containing protein 0.0016 0.0136 0.0308
Brugia malayi hypothetical protein 0.0036 0.0516 0.117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0024 0.0054
Leishmania major trypanothione reductase 0.0168 0.3014 0.8921
Treponema pallidum NADH oxidase 0.0058 0.0935 1
Schistosoma mansoni coup transcription factor 0.001 0.0024 0.0023
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0058 0.0935 0.2803
Onchocerca volvulus Serine\/threonine kinase homolog 0.0186 0.3364 0.763
Entamoeba histolytica hypothetical protein 0.0036 0.0516 0.1208
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0702 0.1592
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0186 0.3364 0.5453
Brugia malayi serine/threonine-protein kinase plk-2 0.0186 0.3364 0.763
Entamoeba histolytica hypothetical protein 0.0036 0.0516 0.1208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0935 0.2501
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0024 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0024 0.0054
Toxoplasma gondii NADPH-glutathione reductase 0.0058 0.0935 0.3099
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0024 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.038 0.038
Echinococcus granulosus smad 0.0016 0.0136 0.0219
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0024 0.0023
Trichomonas vaginalis glutathione reductase, putative 0.0058 0.0935 0.1995
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0058 0.0935 0.2501
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0058 0.0935 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0024 0.0054
Echinococcus granulosus geminin 0.0335 0.6168 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0125 0.0282
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0024 0.0053
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0383 0.7091 0.8958
Trichomonas vaginalis mercuric reductase, putative 0.0058 0.0935 0.1995
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0125 0.0411
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0432 0.0979
Trypanosoma cruzi trypanothione reductase, putative 0.0168 0.3014 0.8921
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0015 0.0125 0.0201
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0024 0.0054
Trichomonas vaginalis set domain proteins, putative 0.023 0.4184 1
Brugia malayi Pre-SET motif family protein 0.0029 0.038 0.0863
Echinococcus multilocularis Smad4 0.0016 0.0136 0.0219
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0015 0.0125 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0935 0.2501
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.3364 0.7979
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0383 0.7091 0.8958
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0024 0.0038
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0015 0.0125 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0702 0.1136
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0426 0.7901 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0024 0.0023
Brugia malayi MH2 domain containing protein 0.0236 0.4296 0.9744
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0024 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0935 0.2501
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0015 0.0125 0.0201
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0024 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0516 0.0835
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0432 0.0979
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0001 0.0002
Brugia malayi ecdysteroid receptor 0.001 0.0024 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0024 0.0054
Schistosoma mansoni glutamate synthase 0.0015 0.0125 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0024 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0702 0.1136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0935 0.2501
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.3364 0.7979
Entamoeba histolytica hypothetical protein 0.0036 0.0516 0.1208
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0001 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.4296 0.9744
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0125 0.0411
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0432 0.0699
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.01 0.1728 0.3919
Loa Loa (eye worm) hypothetical protein 0.0068 0.1128 0.2558
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0058 0.0935 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0024 0.0023
Brugia malayi MH2 domain containing protein 0.0016 0.0136 0.0308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0702 0.0701
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.3364 0.7979
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0136 0.0135
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0024 0.0053
Echinococcus granulosus FTZ F1 alpha 0.001 0.0024 0.0038
Schistosoma mansoni smad1 5 8 and 0.0016 0.0136 0.0135
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.3364 0.3363
Echinococcus multilocularis glutamate synthase 0.0015 0.0125 0.0201
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0186 0.3364 0.5453
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1128 0.2558
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Onchocerca volvulus 0.023 0.4184 0.9492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0702 0.1136
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0058 0.0935 0.2501
Schistosoma mansoni hypothetical protein 0.0335 0.6168 0.6168
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0015 0.0125 0.0282
Schistosoma mansoni hypothetical protein 0.0032 0.0432 0.0431
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0024 0.0054
Schistosoma mansoni thyroid hormone receptor 0.001 0.0024 0.0023
Plasmodium vivax SET domain protein, putative 0.0029 0.038 0.0885
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0024 0.0053
Onchocerca volvulus 0.0015 0.0125 0.0281
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0024 0.0054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.3656 0.8293
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0024 0.0054
Brugia malayi Pax transcription factor protein 2 0.0242 0.4409 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0058 0.0935 0.2501
Loa Loa (eye worm) hypothetical protein 0.0181 0.3265 0.7406
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1728 0.3919
Schistosoma mansoni glutamate synthase 0.0015 0.0125 0.0124
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0015 0.0125 0.0201
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0432 0.0699
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0054
Plasmodium vivax thioredoxin reductase, putative 0.0168 0.3014 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0426 0.7901 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0015 0.0125 0.0282
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0058 0.0935 0.2501
Loa Loa (eye worm) thioredoxin reductase 0.0168 0.3014 0.6837
Plasmodium vivax glutathione reductase, putative 0.0168 0.3014 1
Brugia malayi MH1 domain containing protein 0.0016 0.0136 0.0308
Schistosoma mansoni hypothetical protein 0.0036 0.0516 0.0515
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0058 0.0935 0.2501
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0024 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0702 0.0701
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0054
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0058 0.0935 0.2501
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0043 0.0642 0.1456
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0015 0.0125 0.0201
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0058 0.0935 1
Schistosoma mansoni hypothetical protein 0.0032 0.0432 0.0431
Onchocerca volvulus 0.001 0.0024 0.0053
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0058 0.0935 0.1514
Loa Loa (eye worm) hypothetical protein 0.0015 0.0125 0.0282
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0032 0.0432 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0024 0.0054
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0015 0.0125 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0935 0.2501
Mycobacterium tuberculosis Probable reductase 0.0383 0.7091 0.8958
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.038 0.038
Onchocerca volvulus 0.0029 0.038 0.0861
Schistosoma mansoni sulfide quinone reductase 0.0015 0.0125 0.0124
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0024 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0054
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0383 0.7091 0.8958
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.3265 0.7405
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0058 0.0935 0.0934
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0058 0.0935 0.2501
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0024 0.0038
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.3364 1
Schistosoma mansoni kinase 0.0095 0.1627 0.1626
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0024 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0024 0.0054
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0058 0.0935 1
Plasmodium falciparum thioredoxin reductase 0.0168 0.3014 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.038 0.126
Brugia malayi DIX domain containing protein 0.0009 0.0001 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0024 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.158 0.3586
Entamoeba histolytica serine/threonine protein kinase, putative 0.0186 0.3364 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0054
Onchocerca volvulus 0.0242 0.4409 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0024 0.0054
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0136 0.0219
Loa Loa (eye worm) glutathione reductase 0.0168 0.3014 0.6837
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0024 0.0038
Schistosoma mansoni hypothetical protein 0.0032 0.0432 0.0431
Entamoeba histolytica hypothetical protein 0.0036 0.0516 0.1208
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0383 0.7091 0.8958
Loa Loa (eye worm) pax transcription factor protein 2 0.0242 0.4409 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.036 0.0583
Schistosoma mansoni hypothetical protein 0.0015 0.0125 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.3364 0.7979
Schistosoma mansoni hypothetical protein 0.0335 0.6168 0.6168
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0015 0.0125 0.0201
Brugia malayi glutamate synthase 0.0015 0.0125 0.0282
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0125 0.0411
Loa Loa (eye worm) programmed cell death 8 0.0015 0.0125 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.3364 0.7979
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0024 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0136 0.0308
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0024 0.0038
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0024 0.0038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.038 0.0615
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0024 0.0038
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0058 0.0935 0.2501
Schistosoma mansoni glutamate synthase 0.0015 0.0125 0.0124
Toxoplasma gondii thioredoxin reductase 0.0168 0.3014 1
Brugia malayi Pre-SET motif family protein 0.0202 0.3656 0.8293
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0015 0.0125 0.0411
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0058 0.0935 0.2501
Brugia malayi nuclear hormone receptor 0.001 0.0024 0.0054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0043 0.0642 0.1456
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0024 0.0038
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.3364 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0169 0.3033 0.4917
Brugia malayi nuclear receptor NHR-88 0.001 0.0024 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0702 0.0701
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0058 0.0935 0.2803
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0024 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0024 0.0054
Loa Loa (eye worm) hypothetical protein 0.0029 0.038 0.0863
Giardia lamblia Kinase, PLK 0.0186 0.3364 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0136 0.0219
Echinococcus multilocularis GPCR, family 2 0.0032 0.0432 0.0699
Echinococcus granulosus GPCR family 2 0.0032 0.0432 0.0699
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0024 0.0038
Echinococcus granulosus glutamate synthase 0.0015 0.0125 0.0201
Trypanosoma brucei trypanothione reductase 0.0168 0.3014 0.8921
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0024 0.0038
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0015 0.0125 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0702 0.1136
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.038 0.038
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0068 0.1128 0.1127
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0058 0.0935 0.2501
Plasmodium falciparum thioredoxin reductase 0.0058 0.0935 0.2803
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0024 0.0038
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0001 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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