Detailed information for compound 622711

Basic information

Technical information
  • TDR Targets ID: 622711
  • Name: N-[4-(2,5-dichlorophenyl)-1,3-thiazol-2-yl]ac etamide
  • MW: 287.165 | Formula: C11H8Cl2N2OS
  • H donors: 1 H acceptors: 2 LogP: 3.38 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1scc(n1)c1cc(Cl)ccc1Cl
  • InChi: 1S/C11H8Cl2N2OS/c1-6(16)14-11-15-10(5-17-11)8-4-7(12)2-3-9(8)13/h2-5H,1H3,(H,14,15,16)
  • InChiKey: MHDVQRWAECSACO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(2,5-dichlorophenyl)thiazol-2-yl]acetamide
  • N-[4-(2,5-dichlorophenyl)-2-thiazolyl]acetamide
  • N-[4-(2,5-dichlorophenyl)-1,3-thiazol-2-yl]ethanamide
  • Oprea1_472170
  • T0513-3159
  • ZINC03264857

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.8861 1
Schistosoma mansoni nuclear receptor 0.0005 0.017 0.017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.1105 0.1105
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.1105 0.2376
Schistosoma mansoni cpg binding protein 0.0029 0.465 0.465
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0474 0.1806
Loa Loa (eye worm) hypothetical protein 0.0005 0.027 0.0619
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.1105 0.2532
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0474 0.1806
Loa Loa (eye worm) hypothetical protein 0.0005 0.027 0.0619
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.017 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.1105 0.2532
Loa Loa (eye worm) hypothetical protein 0.001 0.1105 0.2532
Brugia malayi ecdysone receptor 0.0005 0.017 0.0389
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.1105 0.2532
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.1105 0.2376
Brugia malayi CXXC zinc finger family protein 0.0028 0.4363 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.2628 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0584 0.1257
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.2628 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.027 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Brugia malayi Nuclear hormone receptor E75 0.0005 0.017 0.0389
Onchocerca volvulus 0.001 0.1105 0.2532
Brugia malayi nuclear receptor NHR-88 0.0005 0.017 0.0389
Echinococcus multilocularis FTZ F1 alpha 0.001 0.1105 0.2376
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.017 0.017
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.2628 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.2628 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.027 0.0619
Schistosoma mansoni coup transcription factor 0.001 0.1105 0.1105
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0584 0.1257
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.2628 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.1105 0.2532
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.017 0.0389
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.027 0.027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.2628 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0584 0.1257
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.1105 0.1105
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Schistosoma mansoni cpg binding protein 0.0029 0.465 0.465
Loa Loa (eye worm) hypothetical protein 0.001 0.1105 0.2532
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.1105 0.1105
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.017 0.0365
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.017 0.0389
Schistosoma mansoni ap endonuclease 0.0018 0.2628 0.2628
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0891 0.1916
Onchocerca volvulus 0.0005 0.017 0.0389
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.027 0.0581
Toxoplasma gondii exonuclease III APE 0.0018 0.2628 0.2966
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.027 0.027
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.017 0.0389
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.1105 0.2532
Schistosoma mansoni nuclear hormone receptor 0.001 0.1105 0.1105
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.1105 0.2532
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0584 0.0584
Brugia malayi steroid hormone receptor 0.001 0.1105 0.2532
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.017 0.0365
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.1105 0.2376
Loa Loa (eye worm) hypothetical protein 0.001 0.1105 0.2532
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Loa Loa (eye worm) steroid hormone receptor 0.001 0.1105 0.2532
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.1105 0.2532
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.1105 0.1105
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.2628 0.6023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.1105 0.2532
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.2628 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.017 0.017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0474 0.1806
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.017 0.017
Echinococcus granulosus cpg binding protein 0.0029 0.465 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.1105 0.1105
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.1105 0.2376
Brugia malayi nuclear receptor NHR-88 0.001 0.1105 0.2532
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.2628 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.1105 0.2532
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.017 0.0365
Brugia malayi hypothetical protein 0.0005 0.027 0.0619
Loa Loa (eye worm) hypothetical protein 0.001 0.1105 0.2532
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.1105 0.2376
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.027 0.0619
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.017 0.0365
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0056 0.0056
Brugia malayi hypothetical protein 0.0005 0.017 0.0389
Onchocerca volvulus 0.0005 0.017 0.0389
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.1105 0.2376
Schistosoma mansoni thyroid hormone receptor 0.001 0.1105 0.1105
Brugia malayi nuclear receptor NHR-67 0.0005 0.017 0.0389
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.4363 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.1105 0.2532
Schistosoma mansoni nuclear hormone receptor 0.0005 0.017 0.017
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0584 0.1257
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.1105 0.2376
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0474 0.1806
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.1105 0.2532
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Brugia malayi ecdysteroid receptor 0.001 0.1105 0.2532
Echinococcus granulosus FTZ F1 alpha 0.001 0.1105 0.2376
Schistosoma mansoni nuclear hormone receptor 0.0005 0.017 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0474 0.1806
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.1105 0.1105
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.1105 0.2532
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.1105 0.2376
Brugia malayi hypothetical protein 0.0005 0.017 0.0389
Brugia malayi nuclear hormone receptor 0.001 0.1105 0.2532
Schistosoma mansoni zinc finger protein 0.0005 0.017 0.017
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.017 0.0389
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0891 0.1916
Schistosoma mansoni ap endonuclease 0.0018 0.2628 0.2628
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.017 0.0389
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.027 0.0619
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.1105 0.1105
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.2628 0.6023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0474 0.1806
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Schistosoma mansoni thyroid hormone receptor 0.001 0.1105 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.1105 0.2532
Brugia malayi conserved hypotetical protein 0.0005 0.017 0.0389
Schistosoma mansoni cpg binding protein 0.0028 0.4363 0.4363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.1105 0.2376
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.2628 0.5651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.1105 0.2532
Trichomonas vaginalis helicase, putative 0.0006 0.0474 0.1806
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.027 0.0581
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.2628 1
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0871 0.1996
Loa Loa (eye worm) hypothetical protein 0.001 0.1105 0.2532
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.2628 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.017 0.0365
Brugia malayi nuclear hormone receptor 0.0005 0.017 0.0389
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.017 0.0365
Onchocerca volvulus 0.0028 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.027 0.0619
Loa Loa (eye worm) hypothetical protein 0.0005 0.027 0.0619
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.017 0.0365
Onchocerca volvulus Bile acid receptor homolog 0.001 0.1105 0.2532
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.1105 0.2532
Echinococcus multilocularis cpg binding protein 0.0029 0.465 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.2628 0.5651
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.1105 0.2376
Schistosoma mansoni nuclear receptor 0.0005 0.017 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.1105 0.2532
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.017 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.1105 0.2532
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.1105 0.2532
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.1105 0.2376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.1105 0.2532
Brugia malayi hypothetical protein 0.0005 0.027 0.0619
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.2628 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.017 0.0365
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.017 0.0389
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.1105 0.2376
Brugia malayi tailless protein 0.0005 0.017 0.0389
Loa Loa (eye worm) hypothetical protein 0.0005 0.017 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.1105 0.2532
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.1105 0.2376
Loa Loa (eye worm) hypothetical protein 0.001 0.1105 0.2532
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.017 0.0365
Brugia malayi Nuclear hormone receptor E75 0.0005 0.017 0.0389
Loa Loa (eye worm) hypothetical protein 0.001 0.1105 0.2532
Loa Loa (eye worm) hypothetical protein 0.001 0.1105 0.2532
Brugia malayi Steroid receptor seven-up type 2 0.001 0.1105 0.2532
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.017 0.0365
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0891 0.2042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0474 0.1806
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.2628 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.1105 0.1105
Brugia malayi nuclear receptor RXR 0.0005 0.027 0.0619
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.1105 0.2532
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.1105 0.2376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.1105 0.2532
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0474 0.1806
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.1105 0.2532
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.1105 0.2532
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.1105 0.2376
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.017 0.0365
Brugia malayi nuclear receptor RXR 0.0005 0.017 0.0389
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.2628 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.1105 0.1105
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.017 0.0389
Loa Loa (eye worm) DR-78 0.0005 0.017 0.0389
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.017 0.0365
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.1105 0.2376
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0474 0.1806
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.2628 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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