TDR Targets

Basic information

Technical information

TDR Targets ID: 622989
Name: N-[2-[3-[2-[(4-ethylphenyl)amino]-2-oxoethyl] sulfanylindol-1-yl]ethyl]thiophene-2-carboxam ide
MW: 463.615 | Formula: C25H25N3O2S2
H donors: 2 H acceptors: 2 LogP: 5.13 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)NC(=O)CSc1cn(c2c1cccc2)CCNC(=O)c1cccs1
InChi: 1S/C25H25N3O2S2/c1-2-18-9-11-19(12-10-18)27-24(29)17-32-23-16-28(21-7-4-3-6-20(21)23)14-13-26-25(30)22-8-5-15-31-22/h3-12,15-16H,2,13-14,17H2,1H3,(H,26,30)(H,27,29)
InChiKey: OLZOOCQCKXZSAX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[3-[2-[(4-ethylphenyl)amino]-2-oxo-ethyl]sulfanylindol-1-yl]ethyl]thiophene-2-carboxamide
N-[2-[3-[[2-[(4-ethylphenyl)amino]-2-oxoethyl]thio]-1-indolyl]ethyl]-2-thiophenecarboxamide
N-[2-[3-[[2-[(4-ethylphenyl)amino]-2-keto-ethyl]thio]indol-1-yl]ethyl]thiophene-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0138	0.1065
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0139	0.0217
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.13	0.13
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0387	0.0607
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0574	0.4417
Loa Loa (eye worm)	hypothetical protein	0.0035	0.13	0.2036
Onchocerca volvulus		0.0035	0.13	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0757	0.312
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0138	0.1056
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0019	0.0574	0.0899
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.13	1
Loa Loa (eye worm)	RNA binding protein	0.0124	0.5388	0.8441
Entamoeba histolytica	recQ family helicase, putative	0.0009	0.0121	0.0924
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0138	0.1065
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0139	0.0217
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0139	0.0217
Entamoeba histolytica	hypothetical protein	0.0035	0.1311	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.13	0.13
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.1311	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0757	0.1185
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.13	1
Brugia malayi	beta-lactamase	0.0035	0.13	0.2036
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.13	0.536
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0139	0.0217
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0574	0.4417
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0139	0.0217
Echinococcus granulosus	tar DNA binding protein	0.0124	0.5388	0.8441
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.13	0.13
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0139	0.0217
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0139	0.0217
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0387	0.0607
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.006	0.2425	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0757	0.1185
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0486	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.13	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0139	0.0217
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.13	0.2036
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0139	0.0217
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1904	0.2982
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0139	0.0217
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0486	0.2004
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.13	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0757	0.312
Brugia malayi	ecdysteroid receptor	0.001	0.0139	0.0217
Schistosoma mansoni	coup transcription factor	0.001	0.0139	0.0257
Schistosoma mansoni	hypothetical protein	0.0015	0.0387	0.0719
Loa Loa (eye worm)	hypothetical protein	0.001	0.0139	0.0217
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.13	0.2413
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.006	0.2425	0.2425
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.001	0.0138	0.1065
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0139	0.0217
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0574	0.4417
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0139	0.0257
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0574	0.0899
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0139	0.0217
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0139	0.0217
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.13	0.13
Schistosoma mansoni	hypothetical protein	0.0015	0.0387	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0035	0.13	0.2036
Schistosoma mansoni	hypothetical protein	0.0035	0.1311	0.2433
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0139	0.0217
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0019	0.0574	1
Echinococcus multilocularis	muscleblind protein	0.0146	0.6384	1
Schistosoma mansoni	blooms syndrome DNA helicase	0.0009	0.0121	0.0225
Loa Loa (eye worm)	hypothetical protein	0.001	0.0139	0.0217
Entamoeba histolytica	recQ family helicase, putative	0.0019	0.0574	0.4379
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0124	0.5388	0.8441
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0139	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0486	0.0761
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.13	1
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0757	0.312
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.13	0.2036
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0757	0.0757
Onchocerca volvulus		0.001	0.0139	0.1067
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0139	0.0217
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0757	0.312
Onchocerca volvulus		0.0035	0.13	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.13	0.13
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0486	0.0761
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.2241	0.351
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.1202	0.1883
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0574	0.4417
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0139	0.0217
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0217
Entamoeba histolytica	hypothetical protein	0.0035	0.1311	1
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0139	0.0217
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.1311	0.2433
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0387	0.0607
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0757	0.5772
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.006	0.2425	0.3799
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1904	0.2982
Onchocerca volvulus		0.0011	0.0184	0.1419
Brugia malayi	beta-lactamase family protein	0.0035	0.13	0.2036
Brugia malayi	steroid hormone receptor	0.001	0.0139	0.0217
Onchocerca volvulus		0.0035	0.13	1
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0486	0.8463
Loa Loa (eye worm)	TAR-binding protein	0.0124	0.5388	0.8441
Brugia malayi	nuclear receptor NHR-88	0.001	0.0139	0.0217
Leishmania major	hypothetical protein, conserved	0.0035	0.13	0.536
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0757	0.1185
Mycobacterium ulcerans	hypothetical protein	0.0035	0.13	0.536
Loa Loa (eye worm)	hypothetical protein	0.001	0.0139	0.0217
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.13	0.2036
Brugia malayi	RNA recognition motif domain containing protein	0.0124	0.5388	0.8441
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0139	0.0257
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1904	0.2982
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.13	0.2036
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.5388	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0217
Trichomonas vaginalis	esterase, putative	0.0035	0.13	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0139	0.0217
Schistosoma mansoni	hypothetical protein	0.0015	0.0387	0.0719
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.13	0.13
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0139	0.0217
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0139	0.0217
Loa Loa (eye worm)	RecQ helicase	0.0019	0.0574	0.0899
Loa Loa (eye worm)	beta-lactamase	0.0035	0.13	0.2036
Loa Loa (eye worm)	hypothetical protein	0.0035	0.13	0.2036
Echinococcus granulosus	bloom syndrome protein	0.0019	0.0574	0.0899
Schistosoma mansoni	hypothetical protein	0.0033	0.1202	0.2231
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0442	0.0442
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0139	0.0217
Loa Loa (eye worm)	hypothetical protein	0.001	0.0139	0.0217
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0139	0.0257
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0019	0.0574	0.0899
Plasmodium vivax	ATP-dependent DNA helicase Q1, putative	0.0009	0.0121	0.0932
Echinococcus granulosus	muscleblind protein	0.0146	0.6384	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0139	0.0257
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0139	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1904	0.2982
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0442	0.0442
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0757	0.5772
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0139	0.0217
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0139	0.1067
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0442	0.0442
Entamoeba histolytica	hypothetical protein	0.0035	0.1311	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0139	0.0217
Mycobacterium tuberculosis	Conserved protein	0.0035	0.13	0.13
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0139	0.0217
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0139	0.0217
Echinococcus granulosus	GPCR family 2	0.0015	0.0387	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0757	0.1185
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0139	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0146	0.6384	1
Brugia malayi	TAR-binding protein	0.0124	0.5388	0.8441
Mycobacterium tuberculosis	Conserved protein	0.0035	0.13	0.13
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.001	0.0138	0.1065
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0139	0.0217
Treponema pallidum	ATP-dependent DNA helicase	0.001	0.0138	0.5
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0121	0.0932
Loa Loa (eye worm)	hypothetical protein	0.001	0.0139	0.0217
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.5388	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0387	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0574	0.0899
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0139	0.0217
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0757	0.1185
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0757	0.312
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0757	0.312
Loa Loa (eye worm)	hypothetical protein	0.001	0.0139	0.0217
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0486	0.0486
Schistosoma mansoni	hypothetical protein	0.0015	0.0387	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0035	0.13	0.2036
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0757	0.0757
Brugia malayi	Bloom's syndrome protein homolog	0.0019	0.0574	0.0899
Loa Loa (eye worm)	hypothetical protein	0.001	0.0139	0.0217
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0019	0.0574	0.0899
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0139	0.0217
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0139	0.0217
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0139	0.0217
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.006	0.2425	0.3799
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0757	0.5821
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1202	0.1883
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.6384	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.006	0.2425	0.3799
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0139	0.0217
Brugia malayi	RNA binding protein	0.0124	0.5388	0.8441
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0139	0.0217
Loa Loa (eye worm)	hypothetical protein	0.001	0.0139	0.0217
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0139	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0486	0.0761
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0757	0.5821
Loa Loa (eye worm)	hypothetical protein	0.0035	0.13	0.2036
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0574	1
Entamoeba histolytica	hypothetical protein	0.0035	0.1311	1
Mycobacterium ulcerans	lipase LipD	0.0035	0.13	0.536
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.5388	1
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.5388	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.6384	1
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0019	0.0574	0.0899
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0757	0.5772
Brugia malayi	nuclear hormone receptor	0.001	0.0139	0.0217
Giardia lamblia	Sgs1 DNA helicase, putative	0.0019	0.0574	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0139	0.0217
Onchocerca volvulus		0.0023	0.0757	0.5821
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0139	0.0257
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0574	0.0899
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0139	0.0217
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.13	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.006	0.2425	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0019	0.0574	0.4417
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0757	0.312
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.13	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.13	1
Echinococcus multilocularis	bloom syndrome protein	0.0019	0.0574	0.0899
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.13	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0387	0.0607
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.13	0.13
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0139	0.0217
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.1311	0.2054
Mycobacterium ulcerans	beta-lactamase	0.0035	0.13	0.536
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0486	0.0761
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0139	0.0217
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0486	0.3738
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.5388	1
Toxoplasma gondii	ABC1 family protein	0.0035	0.13	1
Schistosoma mansoni	DNA helicase recq1	0.0019	0.0574	0.1066
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0019	0.0574	0.0899
Brugia malayi	beta-lactamase family protein	0.0035	0.13	0.2036
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0139	0.0257
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0442	0.0442
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0139	0.0217
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0139	0.1067
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0387	0.0607
Brugia malayi	hypothetical protein	0.0035	0.1311	0.2054
Brugia malayi	Muscleblind-like protein	0.0146	0.6384	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0139	0.0217
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.006	0.2425	1
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0138	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0035	0.13	0.2036
Schistosoma mansoni	DNA helicase recq5	0.0019	0.0574	0.1066
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.13	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.006	0.2425	0.4501
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.13	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0574	0.4417
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0387	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0486	0.0761
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0387	0.0607
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0757	0.312
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0139	0.0217
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.13	0.536
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0574	0.2368
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0757	0.312
Echinococcus multilocularis	tar DNA binding protein	0.0124	0.5388	0.8441
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0139	0.0257
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0139	0.0257
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0757	0.312
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.13	0.2413
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0387	0.0607
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0139	0.0257
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0139	0.1067
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0757	0.312
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0574	0.4417
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0757	0.1185
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.13	0.13
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0139	0.0217
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0139	0.0257

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 622989