Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.3221 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.5884 | 0.5799 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.5884 | 0.5884 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0784 | 0.0526 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.3221 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3221 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.3221 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.5884 | 0.5768 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.5884 | 0.5799 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.5884 | 0.5884 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5683 | 0.5683 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.5884 | 0.5799 |
Onchocerca volvulus | 0.0033 | 0.5884 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0201 | 0.0201 |
Echinococcus multilocularis | lamin | 0.0033 | 0.5884 | 0.5799 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.5884 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0784 | 0.0784 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.3221 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3221 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.5884 | 0.5768 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3221 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.3221 | 0.3031 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.5884 | 0.5884 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.5884 | 0.5799 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3221 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3221 | 0.3221 |
Echinococcus multilocularis | musashi | 0.0033 | 0.5884 | 0.5799 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7375 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.