Detailed information for compound 623493

Basic information

Technical information
  • TDR Targets ID: 623493
  • Name: N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-(die thylsulfamoyl)benzamide
  • MW: 364.419 | Formula: C16H20N4O4S
  • H donors: 1 H acceptors: 5 LogP: 1.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)C(=O)Nc1nnc(o1)C1CC1)CC
  • InChi: 1S/C16H20N4O4S/c1-3-20(4-2)25(22,23)13-9-7-11(8-10-13)14(21)17-16-19-18-15(24-16)12-5-6-12/h7-10,12H,3-6H2,1-2H3,(H,17,19,21)
  • InChiKey: CCQCIDNJPJZYFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC02720189

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0182 0.4936 0.4936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0851 0.1033
Echinococcus granulosus intermediate filament protein 0.0029 0.0231 0.0231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0851 0.0851
Brugia malayi intermediate filament protein 0.0029 0.0231 0.0281
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1276 0.155
Loa Loa (eye worm) glutaminase 2 0.0283 0.8055 1
Echinococcus granulosus poly adp ribose polymerase 2 0.0159 0.4227 0.4227
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0159 0.4227 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.3228 0.3228
Brugia malayi Pre-SET motif family protein 0.0211 0.5837 0.7089
Loa Loa (eye worm) hypothetical protein 0.0159 0.4227 0.5247
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0231 0.0287
Echinococcus granulosus poly (ADP ribose) polymerase 0.0045 0.0722 0.0722
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.03 0.8582 1
Plasmodium vivax SET domain protein, putative 0.003 0.0272 0.5
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0137 0.3567 0.4332
Schistosoma mansoni intermediate filament proteins 0.0029 0.0231 0.0281
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0289 0.8234 1
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0066 0.1381 0.1381
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0238 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0851 0.0851
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0159 0.4227 0.4227
Schistosoma mansoni hypothetical protein 0.0182 0.4936 0.5994
Brugia malayi WGR domain containing protein 0.0159 0.4227 0.5133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0502 0.0623
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0289 0.8234 0.8234
Echinococcus multilocularis tumor protein p63 0.0346 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0851 0.1033
Echinococcus granulosus poly ADP ribose polymerase 1 0.0289 0.8234 0.8234
Echinococcus multilocularis lamin 0.0029 0.0231 0.0231
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1276 0.1208
Echinococcus granulosus WGR domain containing protein 0.009 0.2103 0.2103
Schistosoma mansoni lamin 0.0029 0.0231 0.0281
Loa Loa (eye worm) hypothetical protein 0.0029 0.0231 0.0287
Loa Loa (eye worm) hypothetical protein 0.022 0.611 0.7586
Loa Loa (eye worm) glutaminase 0.0283 0.8055 1
Echinococcus multilocularis musashi 0.0029 0.0231 0.0231
Echinococcus granulosus poly (ADP ribose) polymerase 0.0045 0.0722 0.0722
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1276 0.155
Echinococcus granulosus poly (ADP ribose) polymerase 0.009 0.2103 0.2103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0851 0.1033
Schistosoma mansoni hypothetical protein 0.0182 0.4936 0.5994
Loa Loa (eye worm) hypothetical protein 0.0028 0.0215 0.0267
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0289 0.8234 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1276 0.1276
Onchocerca volvulus 0.0051 0.0901 0.1337
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0231 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0272 0.0331
Onchocerca volvulus 0.0029 0.0231 0.0343
Trypanosoma brucei poly(adp-ribose) polymerase 0.0159 0.4227 1
Echinococcus multilocularis lamin dm0 0.0029 0.0231 0.0231
Echinococcus granulosus lamin 0.0029 0.0231 0.0231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0851 0.0851
Trichomonas vaginalis glutaminase, putative 0.0283 0.8055 1
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0159 0.4227 0.5133
Onchocerca volvulus DNA ligase 3 homolog 0.0038 0.0502 0.0745
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1276 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0851 0.1056
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0901 0.1094
Echinococcus granulosus lamin dm0 0.0029 0.0231 0.0231
Echinococcus granulosus poly (ADP ribose) polymerase 0.0045 0.0722 0.0722
Schistosoma mansoni hypothetical protein 0.0126 0.3228 0.3921
Onchocerca volvulus 0.024 0.6735 1
Schistosoma mansoni thyroid hormone receptor 0.0136 0.3541 0.43
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.003 0.0272 0.0338
Echinococcus granulosus geminin 0.0182 0.4936 0.4936
Brugia malayi WGR domain containing protein 0.0289 0.8234 1
Schistosoma mansoni lamin 0.0029 0.0231 0.0281
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0851 0.1033
Brugia malayi glutaminase DH11.1 0.0283 0.8055 0.9782
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0272 0.0272
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0114 0.2845 0.3532
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0231 0.0281
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0159 0.4227 1
Onchocerca volvulus 0.0029 0.0231 0.0343
Schistosoma mansoni thyroid hormone receptor 0.0136 0.3541 0.43
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0272 0.0331
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0272 0.0331
Schistosoma mansoni glutaminase 0.0283 0.8055 0.9782
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.3228 0.3228
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.3541 0.3541
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0851 0.0851
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0272 0.0272
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1276 0.1276
Onchocerca volvulus 0.003 0.0272 0.0404
Loa Loa (eye worm) hypothetical protein 0.0051 0.0901 0.1118
Mycobacterium ulcerans glutaminase 0.0283 0.8055 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.5837 0.7246
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1276 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0272 0.0331
Brugia malayi Pre-SET motif family protein 0.003 0.0272 0.0331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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