Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.3514 | 0.2824 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3378 | 0.2673 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.9039 | 0.979 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4163 | 0.4395 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0535 | 0.0592 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.9039 | 0.8936 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0535 | 0.0592 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.405 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.3514 | 0.7399 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3391 | 0.3541 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0535 | 0.0592 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0191 | 0.0211 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7886 | 0.8724 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1992 | 0.1993 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3514 | 0.3678 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3818 | 0.4014 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9228 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.