Detailed information for compound 623661

Basic information

Technical information
  • TDR Targets ID: 623661
  • Name: N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-2-(phe noxy)acetamide
  • MW: 312.386 | Formula: C17H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nc2c(s1)c(C)ccc2C)COc1ccccc1
  • InChi: 1S/C17H16N2O2S/c1-11-8-9-12(2)16-15(11)19-17(22-16)18-14(20)10-21-13-6-4-3-5-7-13/h3-9H,10H2,1-2H3,(H,18,19,20)
  • InChiKey: YHAXBLPUEOUMHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-2-(phenoxy)ethanamide
  • ZINC04331480

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0015
Mycobacterium tuberculosis Conserved protein 0.007 0.1186 0.1291
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.1815 1
Echinococcus granulosus ETS transcription factor Elf 5 0.0021 0.014 0.017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2149 0.234
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1903 0.2072
Onchocerca volvulus 0.0047 0.07 0.59
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0015 0.0015
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1186 0.1186
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0091 0.0169
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0462 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1186 0.1186
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1186 0.1291
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0462 0.2544
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.0196
Loa Loa (eye worm) beta-lactamase 0.007 0.1186 0.1186
Schistosoma mansoni Smad4 0.0015 0.0015 0.0017
Echinococcus granulosus ETS domain containing protein Elk 1 0.0021 0.014 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1623 0.1825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.0196
Onchocerca volvulus 0.007 0.1186 1
Brugia malayi MH1 domain containing protein 0.0033 0.0403 0.0403
Trypanosoma cruzi ISWI complex protein 0.0015 0.0013 0.0074
Loa Loa (eye worm) hypothetical protein 0.0043 0.0606 0.0606
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0091 0.0091
Trichomonas vaginalis esterase, putative 0.007 0.1186 0.2189
Echinococcus granulosus dnaJ subfamily B 0.0405 0.8251 1
Schistosoma mansoni ferritin light chain 0.0017 0.0055 0.0062
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0719 0.3963
Loa Loa (eye worm) hypothetical protein 0.0048 0.0719 0.0719
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0055 0.0102
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0954 0.1157
Plasmodium falciparum thioredoxin reductase 0.0046 0.0667 0.3672
Schistosoma mansoni hypothetical protein 0.0021 0.014 0.0158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0091 0.0504
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0667 0.0726
Trypanosoma brucei ISWI complex protein 0.0015 0.0013 0.0074
Schistosoma mansoni zinc finger protein 0.0021 0.0135 0.0152
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0403 0.0488
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0403 0.0403
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0036 0.0196
Mycobacterium ulcerans hypothetical protein 0.007 0.1186 0.2189
Leishmania major hypothetical protein, conserved 0.01 0.1815 1
Echinococcus multilocularis GA binding protein alpha chain 0.0143 0.2728 0.3306
Loa Loa (eye worm) hypothetical protein 0.0101 0.184 0.184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.042 0.0458
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0034 0.0041
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0034 0.0185
Brugia malayi glutaminase DH11.1 0.0271 0.5415 0.5415
Schistosoma mansoni thyroid hormone receptor 0.0138 0.2609 0.2934
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0036 0.0066
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0021 0.014 0.017
Echinococcus multilocularis ewsr:fli fusion protein type 0.0021 0.014 0.017
Trichomonas vaginalis glutaminase, putative 0.0271 0.5415 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0619 0.075
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1186 0.6532
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0015 0.0018
Schistosoma mansoni hypothetical protein 0.0169 0.3267 0.3674
Brugia malayi transcription factor E74 isoform 0.0021 0.014 0.014
Brugia malayi beta-lactamase family protein 0.007 0.1186 0.1186
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1186 0.1333
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0122 0.0122
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0015 0.0018
Schistosoma mansoni ap endonuclease 0.0018 0.0091 0.0103
Entamoeba histolytica hypothetical protein 0.0144 0.2747 1
Brugia malayi hypothetical protein 0.01 0.1815 0.1815
Echinococcus multilocularis expressed protein 0.0017 0.0055 0.0067
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0034 0.0185
Brugia malayi MH2 domain containing protein 0.0033 0.0403 0.0403
Echinococcus granulosus neuropeptide receptor 0.015 0.2877 0.3486
Plasmodium falciparum thioredoxin reductase 0.0016 0.0036 0.0196
Echinococcus granulosus expressed protein 0.0017 0.0055 0.0067
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0034 0.0185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0485 0.0485
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0091 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0043
Brugia malayi CXXC zinc finger family protein 0.0028 0.0301 0.0301
Loa Loa (eye worm) D-ets-2 protein 0.0021 0.014 0.014
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0719 0.3963
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0055 0.0102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.042 0.0458
Brugia malayi isocitrate dehydrogenase 0.0016 0.0034 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0138 0.2609 0.2934
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0041
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0034 0.0185
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.184 0.184
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0667 0.0808
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0974 0.1096
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0619 0.0619
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0091 0.0504
Schistosoma mansoni ferritin light chain 0.0017 0.0055 0.0062
Echinococcus granulosus expressed conserved protein 0.0095 0.1711 0.2073
Brugia malayi MH2 domain containing protein 0.0033 0.0403 0.0403
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.4596 0.557
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.0196
Schistosoma mansoni zinc finger protein 0.0015 0.0013 0.0015
Trypanosoma cruzi ISWI complex protein 0.0015 0.0013 0.0074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0036 0.0196
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0185
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0034 0.0036
Brugia malayi Bromodomain containing protein 0.0074 0.1267 0.1267
Schistosoma mansoni hypothetical protein 0.0042 0.0586 0.0659
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1903 0.2072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0462 0.0462
Loa Loa (eye worm) MH2 domain-containing protein 0.0488 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0055 0.006
Loa Loa (eye worm) hypothetical protein 0.007 0.1186 0.1186
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0036 0.0196
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.2393 0.29
Brugia malayi MH1 domain containing protein 0.0033 0.0403 0.0403
Mycobacterium tuberculosis Conserved protein 0.007 0.1186 0.1291
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0403 0.0403
Schistosoma mansoni apoferritin-2 0.0017 0.0055 0.0062
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0196
Entamoeba histolytica hypothetical protein 0.0144 0.2747 1
Mycobacterium tuberculosis Conserved protein 0.007 0.1186 0.1291
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0091 0.0504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.042 0.0458
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0091 0.0169
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0719 0.3346
Schistosoma mansoni gabp alpha 0.0143 0.2728 0.3068
Brugia malayi Thioredoxin reductase 0.0046 0.0667 0.0667
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0021 0.014 0.014
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0091 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0619 0.075
Loa Loa (eye worm) hypothetical protein 0.007 0.1186 0.1186
Echinococcus multilocularis protein dispatched 1 0.005 0.0749 0.0907
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0091 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0196
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0036 0.0196
Schistosoma mansoni smad 0.0033 0.0403 0.0453
Schistosoma mansoni hypothetical protein 0.0042 0.0586 0.0659
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1903 0.8856
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1186 0.6532
Loa Loa (eye worm) Smad1 0.0033 0.0403 0.0403
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0036 0.0039
Onchocerca volvulus 0.007 0.1186 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1186 0.2189
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0403 0.0488
Schistosoma mansoni hypothetical protein 0.0021 0.014 0.0158
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0055 0.006
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0091 0.0091
Toxoplasma gondii LsmAD domain-containing protein 0.01 0.1815 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1623 0.1623
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0091 0.0169
Schistosoma mansoni ferritin 0.0017 0.0055 0.0062
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0036 0.0196
Echinococcus granulosus ETS transcription factor Elf 2 0.0021 0.014 0.017
Loa Loa (eye worm) hypothetical protein 0.0232 0.4596 0.4596
Brugia malayi Ets-domain containing protein 0.0021 0.014 0.014
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0719 0.0719
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.0196
Brugia malayi Ets-domain containing protein 0.0143 0.2728 0.2728
Onchocerca volvulus 0.0048 0.0719 0.6066
Echinococcus granulosus Smad4 0.0033 0.0403 0.0488
Schistosoma mansoni hypothetical protein 0.002 0.0122 0.0138
Trypanosoma brucei PAB1-binding protein , putative 0.01 0.1815 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1186 0.1186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.0196
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0015 0.0015
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1903 0.2072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0089 0.0089
Schistosoma mansoni ferritin 0.0017 0.0055 0.0062
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0049 0.0055
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0462 0.0503
Brugia malayi Fli-1 protein 0.0435 0.8891 0.8891
Brugia malayi hypothetical protein 0.0232 0.4596 0.4596
Loa Loa (eye worm) glutaminase 0.0271 0.5415 0.5415
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0719 0.1328
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0143 0.2728 0.2728
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0619 0.075
Echinococcus multilocularis protein patched 0.0043 0.0619 0.075
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1186 0.1291
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0887 0.4885
Echinococcus multilocularis ets variant gene 4 0.0021 0.014 0.017
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1903 0.2072
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0719 0.1328
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0196 0.0237
Loa Loa (eye worm) ets-domain-containing protein 0.0021 0.014 0.014
Echinococcus granulosus cpg binding protein 0.0032 0.0375 0.0454
Trichomonas vaginalis ferritin, putative 0.0017 0.0055 0.0102
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.2747 0.3329
Plasmodium falciparum glutathione reductase 0.0046 0.0667 0.3672
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0034 0.0185
Trypanosoma brucei trypanothione reductase 0.0046 0.0667 0.3672
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1186 0.1333
Echinococcus granulosus smad 0.0033 0.0403 0.0488
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0062 0.0076
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0036 0.0196
Loa Loa (eye worm) hypothetical protein 0.0043 0.0619 0.0619
Echinococcus multilocularis G protein coupled receptor 139 0.015 0.2877 0.3486
Echinococcus multilocularis smad 0.0033 0.0403 0.0488
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.0196
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0036 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1623 0.1966
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0462 0.2544
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2149 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0719 0.0719
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0062 0.007
Schistosoma mansoni ap endonuclease 0.0018 0.0091 0.0103
Mycobacterium ulcerans beta-lactamase 0.007 0.1186 0.2189
Echinococcus multilocularis protein C ets 2 0.0021 0.014 0.017
Brugia malayi hypothetical protein 0.0144 0.2747 0.2747
Loa Loa (eye worm) hypothetical protein 0.0036 0.0462 0.0462
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0015 0.0124
Schistosoma mansoni bromodomain containing protein 0.0063 0.1027 0.1156
Brugia malayi Ets-domain containing protein 0.0143 0.2728 0.2728
Echinococcus multilocularis Smad4 0.0033 0.0403 0.0488
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0034 0.0185
Leishmania major hypothetical protein, conserved 0.0015 0.0013 0.0074
Schistosoma mansoni patched 1 0.0043 0.0619 0.0696
Echinococcus multilocularis cpg binding protein 0.0032 0.0375 0.0454
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0719 0.0719
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0055 0.3551
Mycobacterium ulcerans lipase LipD 0.007 0.1186 0.2189
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1623 0.1966
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0036 0.0066
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0954 0.1157
Plasmodium vivax ataxin-2 like protein, putative 0.01 0.1815 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.07 0.07
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0091 0.0504
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.1873 0.2107
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0719 0.2618
Echinococcus granulosus ETS transcription factor Elf 1 0.0021 0.014 0.017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0036 0.0066
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0719 0.0719
Schistosoma mansoni cpg binding protein 0.0028 0.0301 0.0339
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0034 0.0034
Echinococcus granulosus ewsr:fli fusion protein type 0.0021 0.014 0.017
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0091 0.0504
Schistosoma mansoni hypothetical protein 0.0128 0.2393 0.2691
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0036 0.0196
Schistosoma mansoni ferritin 0.0017 0.0055 0.0062
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1186 0.1291
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0036 0.004
Schistosoma mansoni hypothetical protein 0.0144 0.2747 0.3089
Onchocerca volvulus 0.0028 0.0301 0.2542
Toxoplasma gondii ABC1 family protein 0.007 0.1186 0.6532
Echinococcus multilocularis ETS transcription factor Elf 2 0.0021 0.014 0.017
Echinococcus granulosus GA binding protein alpha chain 0.0143 0.2728 0.3306
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0041
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.184 0.223
Brugia malayi PHD-finger family protein 0.0026 0.0244 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1623 0.1825
Loa Loa (eye worm) hypothetical protein 0.0036 0.0462 0.0462
Loa Loa (eye worm) fli-1 protein 0.0435 0.8891 0.8891
Schistosoma mansoni smad1 5 8 and 0.0033 0.0403 0.0453
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0091 0.0111
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0034 0.0185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1623 0.1966
Schistosoma mansoni smad 0.0015 0.0015 0.0017
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0015 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0041
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0719 0.1328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1623 0.1825
Echinococcus multilocularis ferritin 0.0017 0.0055 0.0067
Schistosoma mansoni smad1 5 8 and 0.0033 0.0403 0.0453
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0667 0.3672
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.1815 1
Schistosoma mansoni hypothetical protein 0.0405 0.8251 0.928
Mycobacterium tuberculosis Probable reductase 0.0104 0.1903 0.2072
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0034 0.0034
Brugia malayi Bromodomain containing protein 0.0037 0.0483 0.0483
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0015 0.0018
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0021 0.014 0.014
Schistosoma mansoni neuropeptide receptor 0.015 0.2877 0.3235
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0049 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0062 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0719 0.0783
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0062 0.0076
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0196 0.022
Mycobacterium leprae conserved hypothetical protein 0.007 0.1186 0.5516
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.2609 0.3162
Schistosoma mansoni hypothetical protein 0.0042 0.0586 0.0659
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2149 0.234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0462 0.0462
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.0196
Mycobacterium ulcerans glutaminase 0.0271 0.5415 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1186 0.1186
Plasmodium vivax glutathione reductase, putative 0.0046 0.0667 0.3672
Onchocerca volvulus 0.007 0.1186 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0826 0.0826
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0034 0.0041
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0036 0.0196
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0403 0.0488
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0036 0.0196
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1186 0.1437
Loa Loa (eye worm) hypothetical protein 0.0021 0.014 0.014
Plasmodium falciparum glutathione reductase 0.0016 0.0036 0.0196
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0719 0.2618
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0533
Schistosoma mansoni hypothetical protein 0.0169 0.3267 0.3674
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.8251 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0049 0.0055
Echinococcus multilocularis ETS transcription factor Elf 1 0.0021 0.014 0.017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2149 0.234
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.2393 0.29
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0719 0.3963
Mycobacterium ulcerans hypothetical protein 0.0048 0.0719 0.1328
Schistosoma mansoni ets 0.0021 0.014 0.0158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0042 0.0586 0.0659
Loa Loa (eye worm) hypothetical protein 0.0068 0.1145 0.1145
Schistosoma mansoni ets-related 0.0021 0.014 0.0158
Schistosoma mansoni Smad4 0.0033 0.0403 0.0453
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1186 0.2189
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0091 0.0111
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0667 0.3672
Echinococcus granulosus zinc finger protein 0.0021 0.0135 0.0164
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1186 0.1437
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.4596 0.557
Loa Loa (eye worm) nuclear factor I 0.0018 0.0089 0.0089
Brugia malayi Smad1 0.0033 0.0403 0.0403
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0403 0.0488
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0055 0.3551
Schistosoma mansoni cpg binding protein 0.0032 0.0375 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0619 0.1143
Loa Loa (eye worm) transcription factor SMAD2 0.0488 1 1
Mycobacterium leprae Probable lipase LipE 0.007 0.1186 0.5516
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0036 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.0196
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0185
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0049 0.006
Brugia malayi DNA-binding protein D-ETS-3 0.0021 0.014 0.014
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0649 0.0787
Echinococcus granulosus geminin 0.0169 0.3267 0.3959
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1186 0.1291
Loa Loa (eye worm) hypothetical protein 0.007 0.1186 0.1186
Brugia malayi beta-lactamase 0.007 0.1186 0.1186
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.2747 0.3329
Echinococcus granulosus ETS transcription factor Elf 2 0.0021 0.014 0.017
Schistosoma mansoni ferritin 0.0017 0.0055 0.0062
Schistosoma mansoni smad1 5 8 and 0.0033 0.0403 0.0453
Loa Loa (eye worm) hypothetical protein 0.0036 0.0462 0.0462
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0719 0.1328
Brugia malayi MH1 domain containing protein 0.0018 0.0089 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1186 0.2189
Schistosoma mansoni cpg binding protein 0.0032 0.0375 0.0421
Echinococcus granulosus protein C ets 2 0.0021 0.014 0.017
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0036 0.0196
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.184 0.223
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0034 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.1815 1
Brugia malayi beta-lactamase family protein 0.007 0.1186 0.1186
Brugia malayi glutathione reductase 0.0046 0.0667 0.0667
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0066
Echinococcus multilocularis neuropeptide receptor 0.015 0.2877 0.3486
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0667 0.0667
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0301 0.0301
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0091 0.0504
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0435 0.0527
Echinococcus multilocularis ETS transcription factor Elf 2 0.0021 0.014 0.017
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.2747 0.3089
Schistosoma mansoni survival motor neuron protein 0.0047 0.07 0.0787
Loa Loa (eye worm) hypothetical protein 0.007 0.1186 0.1186
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0719 0.2618
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0021 0.014 0.0158
Leishmania major trypanothione reductase 0.0046 0.0667 0.3672
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0667 0.0808
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0036 0.0066
Toxoplasma gondii thioredoxin reductase 0.0046 0.0667 0.3672
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.184 0.67
Schistosoma mansoni hypothetical protein 0.0047 0.07 0.0787
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0719 0.1328
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0036 0.0196
Schistosoma mansoni apoferritin-2 0.0017 0.0055 0.0062
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.9186 1
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1186 0.6532
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0719 0.1328
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0036 0.0196
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1186 0.2189
Echinococcus multilocularis expressed conserved protein 0.0095 0.1711 0.2073
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0055 0.0258
Echinococcus multilocularis zinc finger protein 0.0021 0.0135 0.0164
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0144 0.2747 1
Entamoeba histolytica hypothetical protein 0.0144 0.2747 1
Leishmania major hypothetical protein, conserved 0.007 0.1186 0.6532
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1186 0.2189
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0462 0.0853
Brugia malayi MH2 domain containing protein 0.0015 0.0015 0.0015
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0403 0.0453
Echinococcus granulosus ferritin 0.0017 0.0055 0.0067
Brugia malayi MH1 domain containing protein 0.0018 0.0089 0.0089
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.2758 0.3343
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1186 0.1291
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1186 0.1291
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1186 0.1291
Loa Loa (eye worm) hypothetical protein 0.0021 0.014 0.014
Echinococcus multilocularis ETS transcription factor Elf 5 0.0021 0.014 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1623 0.1966
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1903 0.2072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1623 0.1623
Schistosoma mansoni elf1 0.0021 0.014 0.0158
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1186 0.2189
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1186 0.2189
Plasmodium vivax hypothetical protein, conserved 0.007 0.1186 0.6532
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0091 0.01
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0719 0.0783
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0719 0.3346
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0196 0.0237
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0719 0.1328
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0649 0.0787
Loa Loa (eye worm) hypothetical protein 0.01 0.1815 0.1815
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.2758 0.3343
Loa Loa (eye worm) glutaminase 2 0.0271 0.5415 0.5415
Echinococcus multilocularis geminin 0.0169 0.3267 0.3959
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0719 0.0719
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.042 0.0458
Schistosoma mansoni Smad4 0.0015 0.0015 0.0017
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0041
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.1815 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0435 0.0527
Schistosoma mansoni ets-related 0.0435 0.8891 1
Schistosoma mansoni hypothetical protein 0.0045 0.0649 0.073
Brugia malayi hypothetical protein 0.0065 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0123 0.2289 0.2289
Brugia malayi CHE-14 protein 0.0043 0.0619 0.0619
Schistosoma mansoni glutaminase 0.0271 0.5415 0.6091
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0091 0.0333
Loa Loa (eye worm) glutathione reductase 0.0046 0.0667 0.0667
Toxoplasma gondii exonuclease III APE 0.0018 0.0091 0.0504
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0043

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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