Detailed information for compound 623664

Basic information

Technical information
  • TDR Targets ID: 623664
  • Name: N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-3-meth oxybenzamide
  • MW: 312.386 | Formula: C17H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)Nc1nc2c(s1)c(C)ccc2C
  • InChi: 1S/C17H16N2O2S/c1-10-7-8-11(2)15-14(10)18-17(22-15)19-16(20)12-5-4-6-13(9-12)21-3/h4-9H,1-3H3,(H,18,19,20)
  • InChiKey: DEIUUNSQPQYCLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-3-methoxy-benzamide
  • ZINC04330898

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Schistosoma mansoni hypothetical protein 0.02 1 1
Echinococcus multilocularis geminin 0.02 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0115 0.5349 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0103 0.4726 0.8743
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Brugia malayi Thioredoxin reductase 0.0045 0.1588 0.2788
Brugia malayi glutathione reductase 0.0045 0.1588 0.2788
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0388 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.4692 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.4692 1
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.1588 1
Trypanosoma brucei trypanothione reductase 0.0045 0.1588 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0103 0.4726 0.8743
Entamoeba histolytica hypothetical protein 0.0075 0.3194 1
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.3194 0.2919
Plasmodium vivax thioredoxin reductase, putative 0.0045 0.1588 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.4692 0.4478
Leishmania major trypanothione reductase 0.0045 0.1588 1
Trypanosoma brucei unspecified product 0.0023 0.0388 0.2443
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0103 0.4726 0.8743
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Brugia malayi hypothetical protein 0.0075 0.3194 0.652
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0103 0.4726 0.8743
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0115 0.5349 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0045 0.1588 0.2418
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.4692 0.4478
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0388 0.2443
Entamoeba histolytica hypothetical protein 0.0075 0.3194 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.3194 0.2919
Giardia lamblia DINP protein human, muc B family 0.0023 0.0388 0.5
Schistosoma mansoni hypothetical protein 0.02 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.162 0.1282
Entamoeba histolytica hypothetical protein 0.0075 0.3194 1
Loa Loa (eye worm) glutathione reductase 0.0045 0.1588 0.2788
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.4692 0.4478
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0115 0.5349 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0103 0.4726 0.8743
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0388 0.2443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.4692 0.4478
Plasmodium vivax glutathione reductase, putative 0.0045 0.1588 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.4692 0.4478
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0388 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0388 0.2443
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.162 0.1282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.4692 0.4478
Plasmodium falciparum glutathione reductase 0.0045 0.1588 0.5
Toxoplasma gondii thioredoxin reductase 0.0045 0.1588 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0388 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0388 0.2443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.4692 0.4478
Schistosoma mansoni hypothetical protein 0.0075 0.3194 0.2919
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.3194 0.2919
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0388 0.5
Plasmodium falciparum thioredoxin reductase 0.0045 0.1588 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0115 0.5349 1
Mycobacterium tuberculosis Probable reductase 0.0103 0.4726 0.8743
Entamoeba histolytica hypothetical protein 0.0075 0.3194 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443
Loa Loa (eye worm) thioredoxin reductase 0.0045 0.1588 0.2788
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0388 0.2443

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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