Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0057 | 0.6108 | 0.8437 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.3368 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4163 | 0.4395 |
Brugia malayi | hypothetical protein | 0.0041 | 0.3368 | 0.2661 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.3368 | 0.4271 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0191 | 0.0242 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.562 | 0.7763 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.562 | 0.6008 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3818 | 0.4014 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.562 | 0.7763 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.562 | 0.7127 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.562 | 0.7127 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.3368 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.3368 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.3368 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0535 | 0.0739 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.3368 | 0.4271 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.562 | 0.7127 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0535 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.9228 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.562 | 0.7763 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3391 | 0.3541 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0057 | 0.6108 | 0.8437 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.6108 | 0.5694 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.3378 | 0.2673 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.562 | 0.7763 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.3368 | 0.4652 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0057 | 0.6108 | 0.8437 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.3368 | 0.4652 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.724 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 0.6108 | 0.7746 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0535 | 0.0739 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.562 | 0.5154 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.2951 | 0.4076 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0059 | 0.6453 | 0.8913 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.7886 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.6453 | 0.6075 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.6453 | 0.8183 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.6453 | 0.6929 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.6453 | 0.8183 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.724 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.2951 | 0.4076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.