Detailed information for compound 623724

Basic information

Technical information
  • TDR Targets ID: 623724
  • Name: N-[4-amino-2-[2-[(4-bromophenyl)amino]-2-oxoe thyl]sulfanyl-6-oxo-3H-pyrimidin-5-yl]furan-2 -carboxamide
  • MW: 464.293 | Formula: C17H14BrN5O4S
  • H donors: 4 H acceptors: 5 LogP: 2.51 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Br)CSc1nc(N)c(c(n1)O)NC(=O)c1ccco1
  • InChi: 1S/C17H14BrN5O4S/c18-9-3-5-10(6-4-9)20-12(24)8-28-17-22-14(19)13(16(26)23-17)21-15(25)11-2-1-7-27-11/h1-7H,8H2,(H,20,24)(H,21,25)(H3,19,22,23,26)
  • InChiKey: JXVLOTISGRKFLW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-amino-2-[2-[(4-bromophenyl)amino]-2-oxo-ethyl]sulfanyl-6-oxo-3H-pyrimidin-5-yl]furan-2-carboxamide
  • N-[4-amino-2-[[2-[(4-bromophenyl)amino]-2-oxoethyl]thio]-6-oxo-3H-pyrimidin-5-yl]-2-furancarboxamide
  • N-[4-amino-2-[[2-[(4-bromophenyl)amino]-2-keto-ethyl]thio]-6-keto-3H-pyrimidin-5-yl]-2-furamide
  • ZINC02712509

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0027 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0074 0.0777 0.2549
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0061 0.0061
Trypanosoma brucei heat shock protein, putative 0.0034 0.0289 0.2848
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0125 0.0409
Trypanosoma brucei heat shock protein, putative 0.0034 0.0289 0.2848
Loa Loa (eye worm) hypothetical protein 0.0074 0.0777 0.2549
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.1014 0.2633
Plasmodium vivax JmjC domain containing protein 0.0015 0.0061 0.0235
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0101 0.0101
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0105 0.1035
Mycobacterium tuberculosis Conserved protein 0.0074 0.0777 0.1375
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0125 0.0409
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0777 0.1375
Echinococcus multilocularis tar DNA binding protein 0.0259 0.3047 0.3047
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0204 0.0361
Schistosoma mansoni hypothetical protein 0.008 0.0856 0.0856
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0577 0.0577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1013 0.1013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0113 0.1117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.373 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0006 0.0019
Schistosoma mansoni intermediate filament proteins 0.0027 0.0207 0.0207
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0019
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0777 0.442
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0061 0.0597
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1381 0.1381
Echinococcus multilocularis cpg binding protein 0.0061 0.0624 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0125 0.0409
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Brugia malayi steroid hormone receptor 0.0021 0.0125 0.0409
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0125 0.0125
Toxoplasma gondii exonuclease III APE 0.002 0.0113 0.0929
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0093 0.1014 1
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0289 0.2848
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1013 0.1013
Loa Loa (eye worm) RNA binding protein 0.0259 0.3047 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0313 0.3082
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0113 0.0645
Echinococcus granulosus tar DNA binding protein 0.0259 0.3047 0.3047
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0043 0.0355
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1013 0.1013
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.373 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0125 0.0125
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0105 0.0345
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0577 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0125 0.0409
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0105 0.0345
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0409
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0061 0.0061
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.1757 1
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0204 0.0461
Loa Loa (eye worm) hypothetical protein 0.0074 0.0777 0.2549
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0061 0.0199
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0313 0.3082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0125 0.0125
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0043 0.0043
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1013 0.1013
Giardia lamblia Fructose-bisphosphate aldolase 0.0314 0.373 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.298 0.9781
Echinococcus granulosus lamin dm0 0.0027 0.0207 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0125 0.0409
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0125 0.0125
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0093 0.0305
Schistosoma mansoni hypothetical protein 0.008 0.0856 0.0856
Loa Loa (eye worm) inositol-1 0.0036 0.0313 0.1026
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0113 0.0215
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0289 0.2848
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1013 0.1013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0125 0.0409
Echinococcus multilocularis heat shock protein 90 0.0027 0.0204 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1014 0.1014
Toxoplasma gondii ABC1 family protein 0.0074 0.0777 0.6367
Loa Loa (eye worm) TAR-binding protein 0.0259 0.3047 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0125 0.0125
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0289 0.069
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0091
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.5414 0.5414
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0856 0.0856
Echinococcus multilocularis lamin dm0 0.0027 0.0207 0.0207
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0043 0.0355
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0204 0.2013
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0204 0.2013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0125 0.0409
Echinococcus multilocularis musashi 0.0027 0.0207 0.0207
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0313 0.1779
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0113 0.1117
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.5414 0.5414
Schistosoma mansoni cpg binding protein 0.0061 0.0624 0.0624
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0113 0.1117
Echinococcus multilocularis heat shock protein 0.0034 0.0289 0.0289
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0207 0.0678
Echinococcus granulosus heat shock protein 90 0.0027 0.0204 0.0204
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0777 0.442
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0125 0.0125
Echinococcus granulosus geminin 0.0174 0.2012 0.2012
Brugia malayi heat shock protein 90 0.0034 0.0289 0.0948
Loa Loa (eye worm) beta-lactamase 0.0074 0.0777 0.2549
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0617 0.2026
Schistosoma mansoni hypothetical protein 0.0173 0.1997 0.1997
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0061 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0125 0.0125
Schistosoma mansoni ap endonuclease 0.002 0.0113 0.0113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.373 1
Entamoeba histolytica protein kinase, putative 0.0093 0.1014 0.2633
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0777 0.0777
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0777 0.1375
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0105 0.0345
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0113 0.0201
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0125 0.0125
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0207 0.0678
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0125 0.0125
Brugia malayi nuclear receptor RXR 0.0011 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0678
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0093 0.0093
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0204 0.0461
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0105 0.0597
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0289 0.2848
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0061 0.0061
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0125 0.0125
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0125 0.0125
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0204 0.1162
Brugia malayi jmjC domain containing protein 0.0015 0.0061 0.0199
Brugia malayi ecdysteroid receptor 0.0021 0.0125 0.0409
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0253 0.298 0.9781
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0125 0.0125
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.1014 1
Leishmania major hypothetical protein, conserved 0.0074 0.0777 0.7658
Brugia malayi Cytochrome P450 family protein 0.0019 0.0105 0.0345
Schistosoma mansoni hypothetical protein 0.008 0.0856 0.0856
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0313 0.3082
Schistosoma mansoni hypothetical protein 0.008 0.0856 0.0856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0125 0.0409
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0113 0.1117
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.008 0.0856 0.281
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0856 0.0856
Trypanosoma brucei heat shock protein, putative 0.0034 0.0289 0.2848
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0314 0.373 1
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0409
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0777 0.2009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0125 0.0125
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0128 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0125 0.0409
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0204 0.0251
Plasmodium falciparum endoplasmin, putative 0.0021 0.0128 0.345
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0253 0.298 0.9781
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0113 0.0113
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0113 0.0113
Mycobacterium ulcerans beta-lactamase 0.0074 0.0777 0.442
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0093 0.1014 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.1014 1
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.14 0.4594
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Plasmodium vivax endoplasmin, putative 0.0034 0.0289 0.3349
Onchocerca volvulus 0.0074 0.0777 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0125 0.0409
Onchocerca volvulus 0.0058 0.0584 0.7371
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.1997 0.6554
Echinococcus granulosus heat shock protein 90 0.0034 0.0289 0.0289
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0061 0.0061
Onchocerca volvulus 0.0021 0.0125 0.111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0125 0.0125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.3047 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0313 0.0313
Schistosoma mansoni heat shock protein 0.0034 0.0289 0.0289
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1013 0.3325
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0266 0.0472
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0113 0.0955
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0125 0.0125
Schistosoma mansoni heat shock protein 0.0014 0.0043 0.0043
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0074 0.0777 0.2549
Brugia malayi RNA binding protein 0.0259 0.3047 1
Onchocerca volvulus 0.0027 0.0207 0.2226
Schistosoma mansoni inositol monophosphatase 0.0036 0.0313 0.0313
Plasmodium falciparum heat shock protein 90 0.0034 0.0289 1
Echinococcus multilocularis lamin 0.0027 0.0207 0.0207
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0049 0.0049
Brugia malayi jmjC domain containing protein 0.0015 0.0061 0.0199
Brugia malayi Protein kinase domain containing protein 0.0093 0.1014 0.3329
Echinococcus multilocularis heat shock protein 90 0.0034 0.0289 0.0289
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0034 0.0034
Echinococcus granulosus GPCR family 2 0.008 0.0856 0.0856
Brugia malayi jmjC domain containing protein 0.0061 0.0617 0.2026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0125 0.0409
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0777 0.1375
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0125 0.0125
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0125 0.111
Brugia malayi hypothetical protein 0.0011 0.0006 0.0019
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0266 0.1516
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0125 0.0409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0409
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0034 0.0034
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0093 0.1014 0.3329
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0777 0.442
Echinococcus multilocularis endoplasmin 0.0027 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0125 0.0409
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0019
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.0204 0.1162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0409
Schistosoma mansoni hypothetical protein 0.0826 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0006
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0617 0.0617
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0204 0.0461
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0125 0.0125
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0289 0.2848
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0125 0.0125
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0777 0.2549
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0289 0.2368
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0111
Brugia malayi TAR-binding protein 0.0259 0.3047 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0125 0.0125
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0043 0.0142
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0113 0.019
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0125 0.0409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0409
Echinococcus multilocularis geminin 0.0174 0.2012 0.2012
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0313 0.0754
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0856 0.281
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0105 0.1035
Schistosoma mansoni heat shock protein 0.0034 0.0289 0.0289
Trypanosoma brucei heat shock protein, putative 0.0034 0.0289 0.2848
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3047 0.3047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0093 0.1008 0.3309
Loa Loa (eye worm) hypothetical protein 0.0173 0.1997 0.6554
Onchocerca volvulus 0.0074 0.0777 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.14 0.4594
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0856 0.0856
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0125 0.0125
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0777 0.2009
Loa Loa (eye worm) hypothetical protein 0.0074 0.0777 0.2549
Leishmania major heat shock protein, putative 0.0014 0.0043 0.0427
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0204 0.2013
Brugia malayi jmjC domain containing protein 0.0015 0.0061 0.0199
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0061 0.0496
Brugia malayi jmjC domain containing protein 0.0015 0.0061 0.0199
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0409
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0207 0.0678
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0125 0.0125
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0093 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0125 0.0409
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0113 0.0372
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0617 0.0617
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0289 0.2848
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0061 0.0199
Brugia malayi nuclear hormone receptor 0.0021 0.0125 0.0409
Schistosoma mansoni hypothetical protein 0.0174 0.2012 0.2012
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0006 0.0006
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0061 0.0496
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0049 0.0049
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0125 0.111
Mycobacterium ulcerans hypothetical protein 0.0074 0.0777 0.442
Leishmania major hypothetical protein, conserved 0.0015 0.0061 0.0597
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.5414 0.5414
Entamoeba histolytica protein kinase, putative 0.0093 0.1014 0.2633
Brugia malayi Inositol-1 0.0036 0.0313 0.1026
Trypanosoma brucei heat shock protein, putative 0.0034 0.0289 0.2848
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0229 0.075
Trypanosoma brucei heat shock protein, putative 0.0034 0.0289 0.2848
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0577 0.0577
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0061 0.0061
Brugia malayi MH2 domain containing protein 0.0124 0.14 0.4594
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0289 0.2848
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0125 0.0409
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0313 0.0754
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1013 0.1013
Brugia malayi beta-lactamase family protein 0.0074 0.0777 0.2549
Brugia malayi Calcitonin receptor-like protein seb-1 0.0253 0.298 0.9781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.373 1
Schistosoma mansoni endoplasmin 0.0034 0.0289 0.0289
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0584 0.1916
Schistosoma mansoni cpg binding protein 0.0058 0.0584 0.0584
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0015 0.0061 0.0199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0409
Schistosoma mansoni ap endonuclease 0.002 0.0113 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1013 0.1013
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0061 0.0061
Trypanosoma brucei heat shock protein, putative 0.0034 0.0289 0.2848
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0777 0.2009
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0313 0.2562
Echinococcus granulosus cpg binding protein 0.0061 0.0624 0.0624
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0204 0.0204
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0101 0.0101
Onchocerca volvulus 0.0074 0.0777 1
Treponema pallidum fructose-bisphosphate aldolase 0.0314 0.373 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0617 0.0617
Brugia malayi Latrophilin receptor protein 2 0.008 0.0856 0.281
Schistosoma mansoni lamin 0.0027 0.0207 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3047 0.3047
Echinococcus granulosus endoplasmin 0.0027 0.0204 0.0204
Brugia malayi beta-lactamase 0.0074 0.0777 0.2549
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1013 0.3325
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0313 0.3082
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.3047 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.122 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0777 0.2009
Schistosoma mansoni hypothetical protein 0.0174 0.2012 0.2012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0856 0.0856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0125 0.0409
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0052 0.0169
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0043 0.0427
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0289 0.0666
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0658
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.1757 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0777 0.2549
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0777 1
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0777 0.1375
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0128 0.0255
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.009 0.0295
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0777 0.7658
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0125 0.0125
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0125 0.0125
Brugia malayi Cytochrome P450 family protein 0.0029 0.0229 0.075
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0856 0.281
Brugia malayi nuclear receptor NHR-88 0.0021 0.0125 0.0409
Onchocerca volvulus 0.0027 0.0207 0.2226
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.1757 0.3111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0125 0.0409
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Echinococcus granulosus neuropeptide s receptor 0.0452 0.5414 0.5414
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0289 0.0485
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0777 0.0777
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0313 0.073
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0289 0.2848
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0777 0.7658
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0313 1
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3047 0.3047
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0061 0.0061
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0289 0.3349
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0125 0.0409
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0061 0.0199
Treponema pallidum heat shock protein 90 0.0027 0.0204 0.0251
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0043 0.0427
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0125 0.111
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0577 0.0577
Brugia malayi Hsp90 protein 0.0014 0.0043 0.0142
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0204 0.4558
Trypanosoma brucei heat shock protein, putative 0.0034 0.0289 0.2848
Giardia lamblia Grp94/Hsp90 0.0027 0.0204 0.0251
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0113 0.0215
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0061 0.0597
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0091
Mycobacterium tuberculosis Conserved protein 0.0074 0.0777 0.1375
Loa Loa (eye worm) hypothetical protein 0.0015 0.0061 0.0199
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0113 0.0372
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0777 0.0777
Echinococcus granulosus dual specificity 0.0093 0.1014 0.1014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0313 0.0754
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0125 0.0409
Brugia malayi jmjC domain containing protein 0.0057 0.0577 0.1893
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0125 0.0409
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0125 0.0125
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0061 0.0061
Echinococcus granulosus intermediate filament protein 0.0027 0.0207 0.0207
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0052 0.0169
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0061 0.0597
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0125 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.373 1
Leishmania major cytochrome p450-like protein 0.0019 0.0105 0.1035
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Brugia malayi intermediate filament protein 0.0027 0.0207 0.0678
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0049 0.0049
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0043 0.0043
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0289 0.2848
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0289 0.0666
Entamoeba histolytica hypothetical protein 0.0093 0.1014 0.2633
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0061 0.0703
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0113 0.2851
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0314 0.373 1
Mycobacterium leprae Probable lipase LipE 0.0074 0.0777 0.442
Brugia malayi beta-lactamase family protein 0.0074 0.0777 0.2549
Echinococcus granulosus heat shock protein 0.0034 0.0289 0.0289
Schistosoma mansoni inositol monophosphatase 0.0036 0.0313 0.0313
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.373 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0105 0.0345
Loa Loa (eye worm) endoplasmin 0.0034 0.0289 0.0948
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0049 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3047 0.3047
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0105 0.1035
Brugia malayi CXXC zinc finger family protein 0.0058 0.0584 0.1916
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Schistosoma mansoni endoplasmin 0.0034 0.0289 0.0289
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0289 0.2368
Schistosoma mansoni cpg binding protein 0.0061 0.0624 0.0624
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Brugia malayi Endoplasmin precursor 0.0034 0.0289 0.0948
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0777 0.1375
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0777 0.7658
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0118 0.1167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Echinococcus multilocularis dnaJ subfamily B 0.0826 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0777 0.2549
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0777 0.1375
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0125 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3047 0.3047
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Echinococcus granulosus phd:f box containing protein 0.0015 0.0061 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0777 0.2009
Mycobacterium tuberculosis Conserved protein 0.0074 0.0777 0.1375
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0289 0.0948
Mycobacterium ulcerans lipase LipD 0.0074 0.0777 0.442
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.5648 1
Trichomonas vaginalis esterase, putative 0.0074 0.0777 0.2009
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0061 0.0061
Leishmania major heat shock protein 83-1 0.0034 0.0289 0.2848
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0043 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0125 0.0409
Loa Loa (eye worm) hypothetical protein 0.0093 0.1008 0.3309
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0777 0.0777
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0125 0.0409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.373 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0061 0.0199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.373 1
Echinococcus granulosus lamin 0.0027 0.0207 0.0207
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0125 0.0125
Echinococcus multilocularis GPCR, family 2 0.008 0.0856 0.0856
Brugia malayi hypothetical protein 0.0011 0.0006 0.0019
Schistosoma mansoni coup transcription factor 0.0021 0.0125 0.0125
Echinococcus multilocularis dual specificity 0.0093 0.1014 0.1014
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0777 0.1375

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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