Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0691 | 0.3374 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.3271 | 0.3207 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0339 | 0.1402 |
Schistosoma mansoni | gliotactin | 0.0042 | 0.0381 | 0.029 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0427 | 0.0814 |
Onchocerca volvulus | 0.0042 | 0.0381 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0311 | 0.4195 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0038 | 0.0331 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.0381 | 0.5 | |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0339 | 0.0249 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.0691 | 0.0604 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3271 | 0.3207 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0311 | 0.4195 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0691 | 0.3374 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0038 | 0.0331 | 0.058 |
Mycobacterium tuberculosis | Possible toxin MazF4 | 0.0147 | 0.1866 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.3271 | 0.7747 |
Echinococcus multilocularis | neuroligin | 0.0042 | 0.0381 | 0.029 |
Loa Loa (eye worm) | carboxylesterase | 0.0042 | 0.0381 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0381 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0381 | 0.0701 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0427 | 0.0337 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0038 | 0.0331 | 0.8276 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0038 | 0.0331 | 0.024 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0093 | 0.1904 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0038 | 0.0331 | 0.5 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0038 | 0.0331 | 0.058 |
Mycobacterium tuberculosis | Toxin MazF6 | 0.0147 | 0.1866 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0042 | 0.0381 | 0.0701 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0339 | 0.8566 |
Onchocerca volvulus | 0.0042 | 0.0381 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Mycobacterium tuberculosis | Possible toxin MazF5 | 0.0147 | 0.1866 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0147 | 0.1866 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.2426 | 0.2355 |
Mycobacterium tuberculosis | Conserved protein | 0.0147 | 0.1866 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.3271 | 0.7747 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.0339 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0381 | 0.0701 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3271 | 0.3207 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0489 | 0.0965 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0427 | 0.0337 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0042 | 0.0381 | 0.029 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0311 | 0.4195 | 0.414 |
Schistosoma mansoni | acetylcholinesterase | 0.0042 | 0.0381 | 0.029 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0038 | 0.0331 | 0.058 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0339 | 0.8566 |
Leishmania major | DNA polymerase eta, putative | 0.0049 | 0.0489 | 0.6617 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0339 | 0.0601 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0339 | 0.0249 |
Leishmania major | DNA polymerase eta, putative | 0.0035 | 0.0282 | 0.316 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0038 | 0.0331 | 0.398 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0339 | 0.0249 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0722 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0691 | 0.0604 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3271 | 0.7747 |
Mycobacterium tuberculosis | Possible toxin MazF7 | 0.0147 | 0.1866 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0038 | 0.0331 | 0.1198 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0691 | 0.3374 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0038 | 0.0331 | 0.6773 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0339 | 0.0249 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3271 | 0.3207 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0339 | 0.0601 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0339 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0093 | 0.1904 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0038 | 0.0331 | 0.058 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.0282 | 0.1067 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0038 | 0.0331 | 0.9662 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0427 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0381 | 0.0701 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0042 | 0.0381 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0381 | 0.0701 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0042 | 0.0381 | 0.029 |
Mycobacterium tuberculosis | Toxin MazF3 | 0.0147 | 0.1866 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0042 | 0.0381 | 0.0701 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0339 | 0.8566 |
Mycobacterium tuberculosis | Toxin MazF9 | 0.0147 | 0.1866 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0339 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.2426 | 0.2355 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0042 | 0.0381 | 0.029 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0038 | 0.0331 | 0.024 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.3271 | 0.3207 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0038 | 0.0331 | 0.8276 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0042 | 0.0381 | 0.1622 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0691 | 0.0604 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0427 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0381 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3271 | 0.7747 |
Echinococcus multilocularis | geminin | 0.0186 | 0.2426 | 0.2355 |
Mycobacterium tuberculosis | Toxin MazF2 | 0.0147 | 0.1866 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0049 | 0.0489 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0049 | 0.0489 | 0.04 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0339 | 0.6943 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Echinococcus granulosus | dna polymerase eta | 0.0049 | 0.0489 | 0.04 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0042 | 0.0381 | 0.029 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0035 | 0.0282 | 0.4775 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3271 | 0.7747 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0042 | 0.0381 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3271 | 0.7747 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0042 | 0.0381 | 0.1622 |
Brugia malayi | Carboxylesterase family protein | 0.0042 | 0.0381 | 0.0701 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0427 | 0.0337 |
Echinococcus granulosus | geminin | 0.0186 | 0.2426 | 0.2355 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0311 | 0.4195 | 0.414 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0722 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0427 | 0.0337 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0042 | 0.0381 | 0.029 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0049 | 0.0489 | 0.0965 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0381 | 0.0701 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.0691 | 0.0604 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0093 | 0.5 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0038 | 0.0331 | 0.024 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.0691 | 1 |
Echinococcus granulosus | neuroligin | 0.0042 | 0.0381 | 0.029 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0042 | 0.0381 | 0.029 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0339 | 0.6225 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0427 | 0.0337 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0427 | 0.0337 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0339 | 0.6225 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0038 | 0.0331 | 0.6014 |
Loa Loa (eye worm) | carboxylesterase | 0.0042 | 0.0381 | 0.0701 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0042 | 0.0381 | 0.1622 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0093 | 0.1904 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.0282 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0339 | 0.4119 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0042 | 0.0381 | 0.029 |
Onchocerca volvulus | 0.0042 | 0.0381 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0093 | 0.1904 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0038 | 0.0331 | 0.6014 |
Mycobacterium tuberculosis | Possible toxin MazF1 | 0.0147 | 0.1866 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0381 | 0.0701 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3271 | 0.3207 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0049 | 0.0489 | 1 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0093 | 0.1904 |
Onchocerca volvulus | 0.0042 | 0.0381 | 0.5 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.0691 | 0.3374 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0042 | 0.0381 | 0.1622 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0042 | 0.0381 | 0.029 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0042 | 0.0381 | 0.029 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.0691 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0042 | 0.0381 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0042 | 0.0381 | 0.029 |
Brugia malayi | Carboxylesterase family protein | 0.0042 | 0.0381 | 0.0701 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.3271 | 0.3207 |
Echinococcus multilocularis | dna polymerase eta | 0.0049 | 0.0489 | 0.04 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0311 | 0.4195 | 0.414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.