Detailed information for compound 623918

Basic information

Technical information
  • TDR Targets ID: 623918
  • Name: N-(4-amino-6-oxo-2-prop-2-enylsulfanyl-3H-pyr imidin-5-yl)furan-2-carboxamide
  • MW: 292.314 | Formula: C12H12N4O3S
  • H donors: 3 H acceptors: 4 LogP: 1.56 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCSc1nc(N)c(c(n1)O)NC(=O)c1ccco1
  • InChi: 1S/C12H12N4O3S/c1-2-6-20-12-15-9(13)8(11(18)16-12)14-10(17)7-4-3-5-19-7/h2-5H,1,6H2,(H,14,17)(H3,13,15,16,18)
  • InChiKey: VNDXJNARGMTBJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-allylsulfanyl-4-amino-6-oxo-3H-pyrimidin-5-yl)furan-2-carboxamide
  • N-[2-(allylthio)-4-amino-6-oxo-3H-pyrimidin-5-yl]-2-furancarboxamide
  • N-[2-(allylthio)-4-amino-6-keto-3H-pyrimidin-5-yl]-2-furamide
  • ZINC02712480

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1543 0.1543
Echinococcus granulosus intermediate filament protein 0.003 0.0618 0.0555
Echinococcus multilocularis peroxidasin 0.0086 0.3096 0.3049
Schistosoma mansoni laminin gamma-3 chain 0.0028 0.0518 0.1489
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0362 1
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0022 0.0281 0.118
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Schistosoma mansoni lamin 0.003 0.0618 0.1819
Schistosoma mansoni peroxidasin 0.0086 0.3096 1
Brugia malayi EGF-like domain containing protein 0.0028 0.0518 0.0518
Schistosoma mansoni hypothetical protein 0.0028 0.0518 0.1489
Loa Loa (eye worm) notch protein 0.0028 0.0518 0.0518
Echinococcus granulosus notch 0.0028 0.0518 0.0454
Treponema pallidum flavodoxin 0.0022 0.0281 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.1886 0.1886
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0058 0.1886 1
Schistosoma mansoni notch 0.0028 0.0518 0.1489
Trichomonas vaginalis sulfite reductase, putative 0.0058 0.1886 1
Echinococcus multilocularis methionine synthase reductase 0.0036 0.0892 0.0831
Echinococcus granulosus fibropellin Ia 0.0028 0.0518 0.0454
Echinococcus multilocularis protein jagged 2 0.0028 0.0518 0.0454
Echinococcus granulosus slit 2 protein 0.0028 0.0518 0.0454
Loa Loa (eye worm) hypothetical protein 0.0024 0.0362 0.0362
Echinococcus multilocularis survival motor neuron protein 1 0.0241 1 1
Trypanosoma cruzi p450 reductase, putative 0.0058 0.1886 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Brugia malayi hypothetical protein 0.0086 0.3096 0.3096
Brugia malayi flavodoxin family protein 0.0058 0.1886 0.1886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1543 0.4876
Brugia malayi Blistered cuticle protein 3 0.0086 0.3096 0.3096
Brugia malayi Cadherin domain containing protein 0.0028 0.0518 0.0518
Giardia lamblia Hypothetical protein 0.0052 0.1591 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0362 0.1512
Onchocerca volvulus Peroxidasin homolog 0.0086 0.3096 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0058 0.1886 1
Brugia malayi Muscle positioning protein 4 0.0028 0.0518 0.0518
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0518 0.0454
Schistosoma mansoni peroxidasin 0.0086 0.3096 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.009
Schistosoma mansoni intermediate filament proteins 0.003 0.0618 0.1819
Onchocerca volvulus Dual oxidase homolog 0.0086 0.3096 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1473 0.1473
Echinococcus multilocularis neurogenic locus notch protein 4 0.0028 0.0518 0.0454
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0362 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0362 0.1512
Echinococcus multilocularis notch 0.0028 0.0518 0.0454
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0058 0.1886 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0362 0.1621
Brugia malayi FAD binding domain containing protein 0.0058 0.1886 0.1886
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0362 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.3096 0.3096
Onchocerca volvulus 0.0086 0.3096 1
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0022 0.0281 0.118
Schistosoma mansoni cell polarity protein 0.0028 0.0518 0.1489
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Echinococcus granulosus delta-like protein 1 0.0028 0.0518 0.0454
Brugia malayi EGF-like domain containing protein 0.0028 0.0518 0.0518
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0058 0.1886 0.1831
Schistosoma mansoni hypothetical protein 0.0028 0.0518 0.1489
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0518 0.0454
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0028 0.0518 0.0572
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0518 0.0454
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Onchocerca volvulus 0.003 0.0618 0.0936
Onchocerca volvulus Peroxidase homolog 0.0086 0.3096 1
Leishmania major hypothetical protein, conserved 0.0022 0.0281 0.118
Chlamydia trachomatis sulfite reductase 0.0036 0.0892 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0362 0.1621
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Onchocerca volvulus 0.0086 0.3096 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0058 0.1886 0.1831
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Loa Loa (eye worm) hypothetical protein 0.0024 0.0362 0.0362
Plasmodium falciparum nitric oxide synthase, putative 0.0058 0.1886 1
Onchocerca volvulus 0.003 0.0618 0.0936
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.009 0.139
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0058 0.1886 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0362 0.1512
Plasmodium vivax flavodoxin domain containing protein 0.0052 0.1591 0.8376
Echinococcus multilocularis musashi 0.003 0.0618 0.0555
Schistosoma mansoni hypothetical protein 0.0049 0.1473 0.4641
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1543 0.1487
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0058 0.1886 0.1831
Brugia malayi GCC2 and GCC3 family protein 0.0028 0.0518 0.0518
Echinococcus granulosus protein jagged 1 0.0028 0.0518 0.0454
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.009 0.0128
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0058 0.1886 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0036 0.0892 0.0892
Loa Loa (eye worm) intermediate filament protein 0.003 0.0618 0.0618
Echinococcus multilocularis slit 2 protein 0.0028 0.0518 0.0454
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0362 0.1512
Echinococcus granulosus lamin dm0 0.003 0.0618 0.0555
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1543 0.1543
Onchocerca volvulus 0.0028 0.0518 0.0572
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0067 0.0067
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.3096 0.3096
Onchocerca volvulus Putative cubilin 0.0028 0.0518 0.0572
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0036 0.0892 0.2725
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0518 0.0518
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0058 0.1886 0.1831
Brugia malayi isocitrate dehydrogenase 0.0018 0.0067 0.0067
Schistosoma mansoni notch 0.0028 0.0518 0.1489
Echinococcus multilocularis fibropellin Ia 0.0028 0.0518 0.0454
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1543 0.1487
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0362 0.0362
Brugia malayi intermediate filament protein 0.003 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Onchocerca volvulus 0.0028 0.0518 0.0572
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0362 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0618 0.0618
Brugia malayi Delta serrate ligand family protein 0.0028 0.0518 0.0518
Schistosoma mansoni slit 0.0028 0.0518 0.1489
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Echinococcus granulosus neurogenic locus protein delta 0.0028 0.0518 0.0454
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0028 0.0518 0.1489
Echinococcus multilocularis protein jagged 1 0.0028 0.0518 0.0454
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Schistosoma mansoni notch 0.0028 0.0518 0.1489
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.009
Toxoplasma gondii flavodoxin domain-containing protein 0.0029 0.0577 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0618 0.0618
Loa Loa (eye worm) FAD binding domain-containing protein 0.0058 0.1886 0.1886
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.0028 0.0518 0.1489
Leishmania major p450 reductase, putative 0.0058 0.1886 1
Brugia malayi Animal haem peroxidase family protein 0.0086 0.3096 0.3096
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0362 0.1512
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1543 0.4876
Brugia malayi FAD binding domain containing protein 0.0036 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Loa Loa (eye worm) Notch2 0.0028 0.0518 0.0518
Onchocerca volvulus 0.0086 0.3096 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Echinococcus multilocularis lamin dm0 0.003 0.0618 0.0555
Schistosoma mansoni septate junction protein 0.0028 0.0518 0.1489
Loa Loa (eye worm) flavodoxin family protein 0.0022 0.0281 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1543 0.4876
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Echinococcus granulosus neural cadherin 0.0028 0.0518 0.0454
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Loa Loa (eye worm) hypothetical protein 0.0024 0.0362 0.0362
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0028 0.0518 0.0518
Giardia lamblia Nitric oxide synthase, inducible 0.0052 0.1591 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0241 1 1
Brugia malayi EGF-like domain containing protein 0.0028 0.0518 0.0518
Brugia malayi EGF-like domain containing protein 0.0028 0.0518 0.0518
Leishmania major cytochrome P450 reductase, putative 0.0052 0.1591 0.8376
Schistosoma mansoni hypothetical protein 0.0028 0.0518 0.1489
Schistosoma mansoni notch 0.0028 0.0518 0.1489
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.009 0.0128
Schistosoma mansoni lamin 0.003 0.0618 0.1819
Echinococcus granulosus lamin 0.003 0.0618 0.0555
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0058 0.1886 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Brugia malayi notch-like transmembrane receptor 0.0028 0.0518 0.0518
Schistosoma mansoni hypothetical protein 0.0028 0.0518 0.1489
Brugia malayi Cadherin domain containing protein 0.0028 0.0518 0.0518
Schistosoma mansoni hypothetical protein 0.0028 0.0518 0.1489
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.3096 0.3096
Schistosoma mansoni hypothetical protein 0.0028 0.0518 0.1489
Onchocerca volvulus 0.0028 0.0518 0.0572
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Onchocerca volvulus Slit protein homolog 0.0028 0.0518 0.0572
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Onchocerca volvulus Peroxidase homolog 0.0086 0.3096 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.1473 0.4641
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0058 0.1886 1
Onchocerca volvulus 0.0049 0.1473 0.4063
Echinococcus multilocularis fat cadherin tumor suppressor 0.0028 0.0518 0.0454
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0058 0.1886 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0362 0.1621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1543 0.1487
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0362 0.1512
Toxoplasma gondii flavodoxin domain-containing protein 0.0029 0.0577 1
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0022 0.0281 0.118
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0518 0.0454
Brugia malayi Peroxidasin 0.0086 0.3096 0.3096
Onchocerca volvulus Chorion peroxidase homolog 0.0086 0.3096 1
Echinococcus granulosus peroxidasin 0.0086 0.3096 0.3049
Echinococcus granulosus protein jagged 2 0.0028 0.0518 0.0454
Schistosoma mansoni notch 0.0028 0.0518 0.1489
Brugia malayi Animal haem peroxidase family protein 0.0086 0.3096 0.3096
Onchocerca volvulus 0.0028 0.0518 0.0572
Onchocerca volvulus Peroxidasin homolog 0.0086 0.3096 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0058 0.1886 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1543 0.1487
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0362 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0058 0.1886 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0028 0.0518 0.0572
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Brugia malayi flavodoxin family protein 0.0022 0.0281 0.0281
Echinococcus multilocularis protein jagged 1 0.0028 0.0518 0.0454
Toxoplasma gondii EGF family domain-containing protein 0.0028 0.0518 0.8843
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Echinococcus granulosus neurogenic locus notch protein 4 0.0028 0.0518 0.0454
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.009
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0022 0.0281 0.118
Schistosoma mansoni diflavin oxidoreductase 0.0029 0.0577 0.1684
Brugia malayi Animal haem peroxidase family protein 0.0086 0.3096 0.3096
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0518 0.0518
Echinococcus multilocularis neural cadherin 0.0028 0.0518 0.0454
Brugia malayi EGF-like domain containing protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Echinococcus multilocularis lamin 0.003 0.0618 0.0555
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0022 0.0281 0.118
Brugia malayi EGF-like domain containing protein 0.0028 0.0518 0.0518
Mycobacterium ulcerans hypothetical protein 0.0024 0.0362 0.1512
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0052 0.1591 0.8159
Echinococcus granulosus methionine synthase reductase 0.0036 0.0892 0.0831
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.3096 0.3096
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0067 0.0067
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0362 0.1512
Brugia malayi Animal haem peroxidase family protein 0.0086 0.3096 0.3096
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0281 0.118
Echinococcus granulosus protein jagged 2 0.0028 0.0518 0.0454
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0518 0.0454
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.009
Echinococcus granulosus survival motor neuron protein 1 0.0241 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0067 0.0651
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0518 0.0454
Schistosoma mansoni cytochrome P450 reductase 0.0058 0.1886 0.6006
Schistosoma mansoni NADPH flavin oxidoreductase 0.0029 0.0597 0.1749
Brugia malayi EGF-like domain containing protein 0.0028 0.0518 0.0518
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0362 0.0362
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0022 0.0281 0.118
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0362 1
Brugia malayi Animal haem peroxidase family protein 0.0086 0.3096 0.3096
Echinococcus granulosus protein jagged 1 0.0028 0.0518 0.0454
Schistosoma mansoni notch 0.0028 0.0518 0.1489
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Loa Loa (eye worm) blistered cuticle protein 3 0.0086 0.3096 0.3096
Loa Loa (eye worm) hypothetical protein 0.0086 0.3096 0.3096
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0518 0.0518
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0362 0.5
Onchocerca volvulus 0.0028 0.0518 0.0572
Loa Loa (eye worm) hypothetical protein 0.0029 0.0593 0.0593

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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