Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0089 | 0.1968 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0089 | 0.1968 | 0.1968 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.1039 | 0.1007 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0204 | 0.0293 |
Echinococcus granulosus | hypothetical protein | 0.006 | 0.1009 | 0.1009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3106 | 0.3082 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0204 | 0.0169 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.2217 | 0.379 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0204 | 0.0169 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0511 | 0.0477 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0511 | 0.0825 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0061 | 0.1039 | 0.1743 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3106 | 0.3082 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0204 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0061 | 0.1039 | 0.1743 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0089 | 0.1968 | 0.5 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0061 | 0.1039 | 0.4732 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0067 | 0.0055 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0089 | 0.1968 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0061 | 0.1039 | 0.4732 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.2217 | 0.379 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0061 | 0.1039 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0089 | 0.1968 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.3106 | 0.5334 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0089 | 0.1968 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.1222 | 0.2061 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0204 | 0.1682 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0061 | 0.1039 | 0.4732 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0204 | 0.0293 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0061 | 0.1039 | 0.4732 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.1039 | 0.1281 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0067 | 0.0032 |
Leishmania major | protein kinase, putative | 0.0061 | 0.1039 | 0.4732 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0204 | 0.0293 |
Echinococcus multilocularis | geminin | 0.0338 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0061 | 0.1039 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0089 | 0.1968 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0067 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.1222 | 0.1191 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0061 | 0.1039 | 0.4732 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0204 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0511 | 0.0477 |
Onchocerca volvulus | 0.0236 | 0.6721 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0204 | 0.0293 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.1968 | 0.194 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0061 | 0.1039 | 0.1007 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0061 | 0.1039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1222 | 0.2061 |
Onchocerca volvulus | 0.0035 | 0.0204 | 0.0252 | |
Schistosoma mansoni | hypothetical protein | 0.0338 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0204 | 0.0293 |
Echinococcus multilocularis | dual specificity | 0.0089 | 0.1968 | 0.194 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0204 | 0.0293 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.3106 | 0.5334 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.3106 | 0.3082 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1939 | 0.3306 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0035 | 0.0035 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0204 | 0.0293 |
Brugia malayi | RNA binding protein | 0.0125 | 0.3106 | 0.5334 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3106 | 0.3082 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0204 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0511 | 0.0825 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0089 | 0.1968 | 0.3358 |
Giardia lamblia | Kinase, CMGC CLK | 0.0061 | 0.1039 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.3106 | 0.5334 |
Entamoeba histolytica | protein kinase, putative | 0.0089 | 0.1968 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.0204 | 0.0252 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0511 | 0.0477 |
Echinococcus multilocularis | 0.006 | 0.1009 | 0.0977 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0067 | 0.0067 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3106 | 0.3082 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0511 | 0.0477 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3106 | 0.3082 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2217 | 0.379 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1009 | 0.1692 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0204 | 0.0293 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0204 | 0.1682 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0067 | 0.0032 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0067 | 0.0055 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0067 | 0.0032 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0067 | 0.0055 |
Onchocerca volvulus | 0.0035 | 0.0204 | 0.0252 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0204 | 0.0293 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.2217 | 0.379 |
Brugia malayi | Protein kinase domain containing protein | 0.0089 | 0.1968 | 0.3358 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0511 | 0.0511 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0067 | 0.0032 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0061 | 0.1039 | 0.4732 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.3106 | 0.5334 |
Trichomonas vaginalis | set domain proteins, putative | 0.0236 | 0.6721 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.5792 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0067 | 0.0032 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.5792 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.6308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1939 | 0.3306 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.3106 | 0.3106 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0067 | 0.0067 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0067 | 0.0032 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0511 | 0.0477 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0204 | 0.0169 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.1039 | 0.1007 |
Leishmania major | protein kinase, putative | 0.0061 | 0.1039 | 0.4732 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.3106 | 0.5334 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0061 | 0.1039 | 0.1039 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0204 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0204 | 0.0293 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0511 | 0.0511 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0204 | 0.0293 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0204 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0204 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0089 | 0.1968 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0067 | 0.0067 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0204 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0067 | 0.0055 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.