TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.475 | Formula: C27H23NO6
H donors: 1 H acceptors: 3 LogP: 4.17 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C1C(=C(C(=O)N1Cc1ccccc1)O)C(=O)c1ccc2c(c1)OCCO2
InChi: 1S/C27H23NO6/c1-32-20-9-5-8-18(14-20)24-23(25(29)19-10-11-21-22(15-19)34-13-12-33-21)26(30)27(31)28(24)16-17-6-3-2-4-7-17/h2-11,14-15,24,30H,12-13,16H2,1H3
InChiKey: VRYBXGBZKGUKRG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0032	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0238	0.0223
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0077	0.0473	0.1476
Echinococcus multilocularis	cyclin B	0.0067	0.0375	0.036
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0067	0.0375	0.1128
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0074	0.0444	0.3356
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0107	0.0784	0.3019
Plasmodium falciparum	ataxin-2 like protein, putative	0.0039	0.0092	0.0242
Schistosoma mansoni	microtubule-associated protein tau	0.0539	0.5198	0.5191
Mycobacterium tuberculosis	Conserved protein	0.0157	0.1292	0.1289
Trichomonas vaginalis	cyclin B3, putative	0.0046	0.0157	0.054
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0107	0.0784	0.2448
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0107	0.0784	0.2448
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0074	0.0444	0.0429
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0032	0.0015	0.0047
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0193	0.0558
Trypanosoma cruzi	fatty acid elongase, putative	0.0069	0.0399	0.1247
Giardia lamblia	DINP protein human, muc B family	0.0034	0.0034	0.0088
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Trichomonas vaginalis	sulfite reductase, putative	0.028	0.255	1
Trypanosoma cruzi	fatty acid elongase, putative	0.0344	0.3203	1
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0173	0.1456	0.1443
Trichomonas vaginalis	D-aminoacylase, putative	0.0157	0.1292	0.5028
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0067	0.0052
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0067	0.0184
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.028	0.255	0.7963
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0069	0.0399	0.0385
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0248	0.2225	0.8715
Brugia malayi	fatty acid elongation protein 3	0.0069	0.0399	0.1206
Trichomonas vaginalis	DNA polymerase eta, putative	0.0034	0.0034	0.0056
Schistosoma mansoni	elongation of fatty acids protein 1	0.0069	0.0399	0.0385
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.028	0.255	1
Echinococcus granulosus	importin subunit beta 1	0.0094	0.0655	0.0642
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0032	0.0017
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.028	0.255	0.7953
Mycobacterium tuberculosis	Probable lipase LipD	0.0157	0.1292	0.1289
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0032	0.0017
Trypanosoma cruzi	p450 reductase, putative	0.0032	0.0015	0.0047
Trichomonas vaginalis	cyclin B, putative	0.0067	0.0375	0.14
Echinococcus granulosus	lysosomal alpha glucosidase	0.0166	0.1389	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1292	0.1279
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0032	0.0017
Trypanosoma cruzi	fatty acid elongase, putative	0.0069	0.0399	0.1247
Schistosoma mansoni	hypothetical protein	0.0033	0.0032	0.0017
Trypanosoma cruzi	cyclin 6, putative	0.0067	0.0375	0.1169
Schistosoma mansoni	kinase	0.0037	0.0073	0.0058
Mycobacterium ulcerans	beta-lactamase	0.0157	0.1292	0.5038
Leishmania major	hypothetical protein, conserved	0.0157	0.1292	0.4035
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0067	0.0163
Mycobacterium tuberculosis	Probable lipase LipE	0.0157	0.1292	0.1289
Schistosoma mansoni	ran	0.007	0.0401	0.0386
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0141	0.1131	0.1118
Onchocerca volvulus		0.0157	0.1292	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.007	0.0401	0.125
Echinococcus multilocularis	cyclin B3 1	0.0046	0.0157	0.0142
Onchocerca volvulus	Elongation of very long chain fatty acids protein homolog	0.0069	0.0399	0.3009
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0067	0.0184
Trypanosoma cruzi	fatty acid elongase, putative	0.0344	0.3203	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0054	0.0238	0.0699
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.1389	0.1376
Brugia malayi	hypothetical protein	0.0039	0.0092	0.0242
Trichomonas vaginalis	CAMK family protein kinase	0.0037	0.0063	0.0169
Leishmania major	cytochrome P450 reductase, putative	0.0248	0.2225	0.6947
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.028	0.255	0.7953
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0034	0.0034	0.0056
Plasmodium vivax	hypothetical protein, conserved	0.0107	0.0784	0.2412
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0444	0.1674
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0444	0.1674
Brugia malayi	RNA, U transporter 1	0.0269	0.2436	0.7595
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.007	0.0401	0.125
Schistosoma mansoni	hypothetical protein	0.1008	1	1
Brugia malayi	beta-lactamase family protein	0.0157	0.1292	0.4007
Schistosoma mansoni	hypothetical protein	0.0072	0.0429	0.0414
Leishmania major	nitrate reductase, putative	0.0032	0.0015	0.0047
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0067	0.0184
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0067	0.0209
Schistosoma mansoni	hypothetical protein	0.0033	0.0032	0.0017
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0032	0.0017
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.028	0.255	0.7963
Trichomonas vaginalis	cyclin D, putative	0.0046	0.0157	0.054
Brugia malayi	hypothetical protein	0.0241	0.2156	0.6717
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0034	0.0034	0.0019
Onchocerca volvulus		0.0067	0.0375	0.2816
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0375	0.036
Mycobacterium ulcerans	esterase/lipase LipP	0.0157	0.1292	0.5038
Trypanosoma cruzi	cyclin, putative	0.0067	0.0375	0.1169
Trypanosoma cruzi	reductase, putative	0.0032	0.0015	0.0047
Brugia malayi	Fatty acid elongation protein 3	0.0344	0.3203	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0157	0.1292	0.1289
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0141	0.1133	0.1119
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0032	0.0053
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0444	0.1674
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0344	0.3203	0.3193
Onchocerca volvulus		0.0069	0.0399	0.3009
Entamoeba histolytica	cyclin, putative	0.0046	0.0157	0.1633
Leishmania major	hypothetical protein, conserved	0.0107	0.0784	0.2448
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0034	0.0034	0.0107
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0034	0.0061
Echinococcus granulosus	GTP binding nuclear protein Ran	0.007	0.0401	0.0386
Echinococcus multilocularis	dna polymerase eta	0.0054	0.0238	0.0223
Mycobacterium ulcerans	DNA polymerase IV	0.0034	0.0034	0.0077
Entamoeba histolytica	cyclin family protein	0.0046	0.0157	0.1633
Echinococcus granulosus	elongation of very long chain fatty acids	0.0069	0.0399	0.0385
Plasmodium vivax	ataxin-2 like protein, putative	0.0039	0.0092	0.0242
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.0344	0.3203	0.3193
Leishmania major	NADH-dependent fumarate reductase, putative	0.0032	0.0015	0.0047
Trichomonas vaginalis	CAMK family protein kinase	0.0037	0.0063	0.0169
Schistosoma mansoni	cyclin B3	0.0141	0.1133	0.1119
Toxoplasma gondii	fatty acid elongase	0.0069	0.0399	0.1247
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0141	0.1133	0.3506
Leishmania major	cytochrome-b5 reductase, putative	0.0032	0.0015	0.0047
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.007	0.0401	0.0386
Echinococcus granulosus	geminin	0.0268	0.2434	0.2423
Echinococcus multilocularis	cyclins	0.0046	0.0157	0.0142
Echinococcus multilocularis	elongation of very long chain fatty acids	0.0069	0.0399	0.0385
Toxoplasma gondii	hypothetical protein	0.0035	0.0044	0.0138
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0067	0.0209
Trypanosoma cruzi	polo-like protein kinase, putative	0.0074	0.0444	0.1385
Entamoeba histolytica	type A flavoprotein, putative	0.0107	0.0784	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0157	0.1292	0.5028
Trypanosoma brucei	mitotic cyclin 6	0.0067	0.0375	0.1128
Leishmania major	hypothetical protein, conserved	0.0039	0.0092	0.0287
Echinococcus granulosus	cyclins	0.0046	0.0157	0.0142
Echinococcus granulosus	cyclins	0.0046	0.0157	0.0142
Onchocerca volvulus		0.0157	0.1292	1
Onchocerca volvulus		0.0049	0.0193	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2156	0.2145
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.0069	0.0399	0.0385
Echinococcus granulosus	beta LACTamase domain containing family member	0.0157	0.1292	0.1279
Trichomonas vaginalis	cyclins, putative	0.0067	0.0375	0.14
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0157	0.1292	0.1279
Trypanosoma brucei	DNA polymerase eta, putative	0.0054	0.0238	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0092	0.0077
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0067	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0399	0.0385
Leishmania major	p450 reductase, putative	0.028	0.255	0.7963
Onchocerca volvulus	Elongation of very long chain fatty acids protein homolog	0.0069	0.0399	0.3009
Brugia malayi	flavodoxin family protein	0.028	0.255	0.7953
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0157	0.1292	0.5038
Schistosoma mansoni	cyclins	0.0046	0.0157	0.0142
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0034	0.0034	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1292	0.1279
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Echinococcus multilocularis	cyclins	0.0046	0.0157	0.0142
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Echinococcus multilocularis	cyclins	0.0046	0.0157	0.0142
Echinococcus multilocularis	elongation of very long chain fatty acids	0.0069	0.0399	0.0385
Trichomonas vaginalis	importin beta-1, putative	0.0077	0.0473	0.1789
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.028	0.255	0.2539
Loa Loa (eye worm)	flavodoxin family protein	0.0107	0.0784	0.077
Schistosoma mansoni	alpha glucosidase	0.0037	0.0067	0.0052
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0074	0.0444	0.0429
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0074	0.0444	0.0429
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0284	0.2595	0.2584
Trichomonas vaginalis	cyclin B, putative	0.0046	0.0157	0.054
Trypanosoma cruzi	fatty acid elongase, putative	0.0069	0.0399	0.1247
Trypanosoma brucei	importin beta-1 subunit, putative	0.0094	0.0655	0.2009
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Plasmodium falciparum	long chain polyunsaturated fatty acid elongation enzyme, putative	0.0069	0.0399	0.1206
Trypanosoma brucei	PAB1-binding protein , putative	0.0039	0.0092	0.0242
Entamoeba histolytica	type A flavoprotein, putative	0.0107	0.0784	1
Schistosoma mansoni	DNA polymerase eta	0.0054	0.0238	0.0223
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0157	0.1292	0.1279
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0067	0.0209
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.028	0.255	0.7963
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.007	0.0401	0.0386
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0032	0.0015	0.0047
Plasmodium falciparum	fatty acid elongation protein, GNS1/SUR4 family, putative	0.0344	0.3203	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0444	0.1674
Trichomonas vaginalis	cyclin D, putative	0.0046	0.0157	0.054
Echinococcus granulosus	elongation of very long chain fatty acids	0.0069	0.0399	0.0385
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0157	0.1292	0.1289
Plasmodium falciparum	ataxin-2 like protein, putative	0.0039	0.0092	0.0242
Schistosoma mansoni	cytochrome P450 reductase	0.028	0.255	0.2539
Schistosoma mansoni	hypothetical protein	0.0033	0.0032	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0067	0.0209
Trichomonas vaginalis	D-aminoacylase, putative	0.0157	0.1292	0.5028
Schistosoma mansoni	cyclin B	0.0067	0.0375	0.036
Trypanosoma brucei	Fatty acid elongase	0.0069	0.0399	0.1206
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0107	0.0784	0.3019
Echinococcus multilocularis	survival motor neuron protein 1	0.0241	0.2156	0.2145
Trypanosoma brucei	unspecified product	0.0034	0.0034	0.0061
Loa Loa (eye worm)	FAD binding domain-containing protein	0.028	0.255	0.2539
Trichomonas vaginalis	cyclin B, putative	0.0067	0.0375	0.14
Schistosoma mansoni	importin beta-1	0.0094	0.0655	0.0642
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0067	0.0375	0.1169
Leishmania major	fatty acid elongase, putative	0.0344	0.3203	1
Onchocerca volvulus		0.0069	0.0399	0.3009
Echinococcus multilocularis	geminin	0.0268	0.2434	0.2423
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0032	0.0015	0.0047
Brugia malayi	flavodoxin family protein	0.0107	0.0784	0.2412
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1292	0.1279
Toxoplasma gondii	integral membrane protein, GNS1/SUR4 family protein, putative	0.0344	0.3203	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0444	0.1674
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0107	0.0784	0.2412
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.028	0.255	0.7953
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0626	0.6095	0.6089
Leishmania major	fatty acid elongase, putative	0.0344	0.3203	1
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0444	0.0429
Toxoplasma gondii	LsmAD domain-containing protein	0.0039	0.0092	0.0287
Echinococcus granulosus	dna polymerase eta	0.0054	0.0238	0.0223
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0032	0.0015	0.0047
Entamoeba histolytica	Ran family GTPase	0.007	0.0401	0.4885
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0034	0.0034	0.002
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0067	0.0433
Echinococcus granulosus	cyclin B3 1	0.0046	0.0157	0.0142
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0284	0.2595	0.2584
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0157	0.1292	0.1279
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0034	0.0034	0.0107
Trichomonas vaginalis	cyclin B, putative	0.0067	0.0375	0.14
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.028	0.255	0.7953
Echinococcus multilocularis	cyclins	0.0046	0.0157	0.0142
Leishmania major	oxidoreductase-like protein	0.0032	0.0015	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0017
Leishmania major	DNA polymerase kappa, putative	0.0034	0.0034	0.0107
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.1001	0.9928	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.007	0.0401	0.125
Leishmania major	DNA polymerase eta, putative	0.0054	0.0238	0.0742
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0067	0.0433
Mycobacterium leprae	conserved hypothetical protein	0.0157	0.1292	0.5
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0069	0.0399	0.0385
Trypanosoma brucei	hypothetical protein, conserved	0.0157	0.1292	0.4007
Brugia malayi	Hypothetical 34.1 kDa protein C40H1.4 in chromosome III	0.0069	0.0399	0.1206
Schistosoma mansoni	elongation of fatty acids protein 1	0.0069	0.0399	0.0385
Brugia malayi	beta-lactamase family protein	0.0157	0.1292	0.4007
Giardia lamblia	Nitric oxide synthase, inducible	0.0248	0.2225	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0067	0.0184
Plasmodium falciparum	nitric oxide synthase, putative	0.028	0.255	0.7953
Echinococcus granulosus	GPCR family 2	0.0033	0.0032	0.0017
Entamoeba histolytica	type A flavoprotein, putative	0.0107	0.0784	1
Mycobacterium leprae	Probable lipase LipE	0.0157	0.1292	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0157	0.1292	0.5028
Echinococcus granulosus	cyclins	0.0046	0.0157	0.0142
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Schistosoma mansoni	hypothetical protein	0.0033	0.0032	0.0017
Brugia malayi	serine/threonine-protein kinase plk-2	0.0074	0.0444	0.1345
Schistosoma mansoni	diflavin oxidoreductase	0.0139	0.1109	0.1096
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.028	0.255	0.7953
Brugia malayi	GNS1/SUR4 family protein	0.0069	0.0399	0.1206
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0067	0.0184
Echinococcus granulosus	cyclin B	0.0067	0.0375	0.036
Mycobacterium tuberculosis	Conserved protein	0.0157	0.1292	0.1289
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0034	0.0034	0.0019
Schistosoma mansoni	ran	0.007	0.0401	0.0386
Loa Loa (eye worm)	hypothetical protein	0.028	0.255	0.2539
Trichomonas vaginalis	cyclins, putative	0.0067	0.0375	0.14
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.077	0.0757
Brugia malayi	fatty acid elongation protein 3	0.0069	0.0399	0.1206
Plasmodium vivax	flavodoxin domain containing protein	0.0248	0.2225	0.6933
Echinococcus multilocularis	cyclins	0.0046	0.0157	0.0142
Plasmodium falciparum	importin beta, putative	0.0094	0.0655	0.2009
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0032	0.0015	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0655	0.0642
Mycobacterium ulcerans	DNA polymerase IV	0.0034	0.0034	0.0077
Entamoeba histolytica	type A flavoprotein, putative	0.0107	0.0784	1
Echinococcus multilocularis	methionine synthase reductase	0.0173	0.1456	0.1443
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.007	0.0401	0.121
Onchocerca volvulus		0.0096	0.0673	0.5149
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0032	0.0015	0.0047
Brugia malayi	fatty acid elongation protein 3	0.0069	0.0399	0.1206
Mycobacterium tuberculosis	Probable hydrolase	0.0157	0.1292	0.1289
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0034	0.0034	0.0019
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0107	0.0784	0.3019
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0067	0.0184
Schistosoma mansoni	fatty acid acyl transferase-related	0.0069	0.0399	0.0385
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0067	0.0184
Leishmania major	importin beta-1 subunit, putative	0.0077	0.0473	0.1476
Toxoplasma gondii	GNS1/SUR4 family protein	0.0344	0.3203	1
Onchocerca volvulus		0.0157	0.1292	1
Trypanosoma cruzi	nitrate reductase, putative	0.0032	0.0015	0.0047
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0141	0.1133	0.1119
Giardia lamblia	Hypothetical protein	0.0046	0.0157	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0429	0.0414
Treponema pallidum	flavodoxin	0.0107	0.0784	1
Brugia malayi	FAD binding domain containing protein	0.028	0.255	0.7953
Trichomonas vaginalis	cyclins, putative	0.0067	0.0375	0.14
Loa Loa (eye worm)	hypothetical protein	0.0106	0.077	0.0757
Leishmania major	long chain polyunsaturated fatty acid elongation enzyme-like protein	0.0069	0.0399	0.1247
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.028	0.255	0.7963
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0032	0.0015	0.0047
Echinococcus granulosus	microtubule associated protein 2	0.0539	0.5198	0.5191
Plasmodium vivax	GNS1/SUR4 domain containing protein	0.0344	0.3203	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0034	0.0034	0.0019
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0034	0.0061
Schistosoma mansoni	hypothetical protein	0.0268	0.2434	0.2423
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.007	0.0401	0.121
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0032	0.0053
Entamoeba histolytica	hypothetical protein	0.0077	0.0473	0.5849
Trypanosoma cruzi	fatty acid elongase, putative	0.0344	0.3203	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0173	0.1456	0.1443
Trypanosoma cruzi	hypothetical protein, conserved	0.0157	0.1292	0.4035
Trypanosoma brucei	Long chain fatty acyl elongase	0.0069	0.0399	0.1206
Entamoeba histolytica	cyclin family protein	0.0046	0.0157	0.1633
Echinococcus granulosus	dna polymerase kappa	0.0034	0.0034	0.0019
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0107	0.0784	0.3019
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.007	0.0401	0.121
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.028	0.255	0.2539
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0067	0.0052
Mycobacterium ulcerans	hypothetical protein	0.0157	0.1292	0.5038
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.028	0.255	0.2539
Plasmodium falciparum	cyclin	0.0046	0.0157	0.0445
Trypanosoma cruzi	fatty acid elongase, putative	0.0069	0.0399	0.1247
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0429	0.1297
Trichomonas vaginalis	cyclins, putative	0.0046	0.0157	0.054
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.077	0.237
Trypanosoma cruzi	PAB1-binding protein , putative	0.0039	0.0092	0.0287
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0284	0.2595	0.2584
Plasmodium vivax	elongation of very long chain fatty acids protein 3, putative	0.0069	0.0399	0.1206
Loa Loa (eye worm)	cyclin domain-containing protein	0.0141	0.1133	0.1119
Trypanosoma brucei	glucosidase, putative	0.0037	0.0067	0.0163
Giardia lamblia	Hypothetical protein	0.0248	0.2225	1
Giardia lamblia	G2/mitotic-specific cyclin B	0.0067	0.0375	0.1627
Chlamydia trachomatis	sulfite reductase	0.0173	0.1456	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0034	0.0061
Loa Loa (eye worm)	beta-lactamase	0.0157	0.1292	0.1279
Brugia malayi	fatty acid elongation protein 3	0.0069	0.0399	0.1206
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0032	0.0015	0.0047
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Trypanosoma cruzi	cyclin, putative	0.0067	0.0375	0.1169
Toxoplasma gondii	HEAT repeat-containing protein	0.0094	0.0655	0.2047
Toxoplasma gondii	ABC1 family protein	0.0157	0.1292	0.4035
Echinococcus multilocularis	importin subunit beta 1	0.0094	0.0655	0.0642
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0284	0.2595	0.2584
Trypanosoma cruzi	DNA polymerase eta, putative	0.0054	0.0238	0.0742
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Trichomonas vaginalis	ran, putative	0.007	0.0401	0.1503
Brugia malayi	MH2 domain containing protein	0.0092	0.0633	0.1938
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0032	0.0015	0.0047
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0077	0.0473	0.1789
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0284	0.2595	0.2584
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0034	0.0034	0.002
Leishmania major	fatty acid elongase, putative	0.0069	0.0399	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1292	0.1279
Trypanosoma cruzi	fatty acid elongase, putative	0.0069	0.0399	0.1247
Echinococcus multilocularis	snurportin 1	0.1008	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0444	0.1674
Trypanosoma brucei	elongation of very long chain fatty acids protein, putative	0.0069	0.0399	0.1206
Echinococcus granulosus	cyclins	0.0046	0.0157	0.0142
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0067	0.0184
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0034	0.0034	0.0107
Plasmodium falciparum	long chain fatty acid elongation enzyme, putative	0.0344	0.3203	1
Plasmodium vivax	long chain polyunsaturated fatty acid elongation enzyme, putative	0.0069	0.0399	0.1206
Echinococcus multilocularis	cyclins	0.0046	0.0157	0.0142
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0077	0.0473	0.1789
Mycobacterium tuberculosis	Conserved protein	0.0157	0.1292	0.1289
Schistosoma mansoni	hypothetical protein	0.0049	0.0193	0.0178
Schistosoma mansoni	alpha-glucosidase	0.0143	0.1153	0.1139
Trichomonas vaginalis	cyclins, putative	0.0067	0.0375	0.14
Leishmania major	cytochrome-b5 reductase, putative	0.0032	0.0015	0.0047
Toxoplasma gondii	flavodoxin domain-containing protein	0.0139	0.1109	0.3463
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Trypanosoma cruzi	fatty acid elongase, putative	0.0069	0.0399	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0375	0.036
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.007	0.0401	0.121
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0069	0.0399	0.0385
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0157	0.054
Trichomonas vaginalis	cyclin B, putative	0.0067	0.0375	0.14
Brugia malayi	beta-lactamase	0.0157	0.1292	0.4007
Mycobacterium ulcerans	lipase LipD	0.0157	0.1292	0.5038
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0284	0.2595	0.2584
Schistosoma mansoni	alpha-glucosidase	0.0143	0.1153	0.1139
Leishmania major	cyclin	0.0067	0.0375	0.1169
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Brugia malayi	ImpB/MucB/SamB family protein	0.0034	0.0034	0.0061
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0074	0.0444	0.546
Trypanosoma cruzi	fatty acid elongase, putative	0.0344	0.3203	1
Trypanosoma brucei	Fatty acid elongase	0.0069	0.0399	0.1206
Entamoeba histolytica	type A flavoprotein, putative	0.0107	0.0784	1
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0032	0.0015	0.0047
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0107	0.0784	0.2412
Plasmodium vivax	hypothetical protein, conserved	0.0157	0.1292	0.4007
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0157	0.1292	0.4007
Trichomonas vaginalis	D-aminoacylase, putative	0.0157	0.1292	0.5028
Echinococcus multilocularis	cyclin b3	0.0046	0.0157	0.0142
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0032	0.0015	0.0047
Leishmania major	reductase, putative	0.0032	0.0015	0.0047
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0067	0.0375	0.1128
Echinococcus multilocularis	cyclins	0.0046	0.0157	0.0142
Brugia malayi	GNS1/SUR4 family protein	0.0344	0.3203	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0034	0.0034	0.0107
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0193	0.0178
Giardia lamblia	Kinase, PLK	0.0074	0.0444	0.194
Trypanosoma brucei	polo-like protein kinase	0.0074	0.0444	0.1345
Toxoplasma gondii	flavodoxin domain-containing protein	0.0139	0.1109	0.3463
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.007	0.0401	0.1745
Echinococcus multilocularis	microtubule associated protein 2	0.0539	0.5198	0.5191
Brugia malayi	FAD binding domain containing protein	0.0173	0.1456	0.4521
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0444	0.1674
Trypanosoma cruzi	p450 reductase, putative	0.028	0.255	0.7963
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0032	0.0017
Loa Loa (eye worm)	ELO-9 protein	0.0069	0.0399	0.0385
Leishmania major	fatty acid elongase, putative	0.0344	0.3203	1
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0107	0.0784	0.2448
Echinococcus multilocularis	dna polymerase kappa	0.0034	0.0034	0.0019
Trypanosoma cruzi	polo-like protein kinase, putative	0.0074	0.0444	0.1385
Echinococcus granulosus	methionine synthase reductase	0.0173	0.1456	0.1443
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0107	0.0784	0.2412
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0032	0.0015	0.0047
Trypanosoma brucei	Fatty acid elongase	0.0344	0.3203	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0284	0.2595	0.2584
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0032	0.0015	0.0047
Mycobacterium tuberculosis	Probable esterase LipL	0.0157	0.1292	0.1289
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0032	0.0015	0.0047
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0067	0.0184
Brugia malayi	Importin beta-1 subunit	0.0094	0.0655	0.2009
Plasmodium vivax	importin-beta 2, putative	0.0094	0.0655	0.2009
Echinococcus granulosus	survival motor neuron protein 1	0.0241	0.2156	0.2145
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1292	0.1279
Trypanosoma brucei	importin beta-1 subunit, putative	0.0094	0.0655	0.2009
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.1008	1	1
Echinococcus granulosus	cyclins	0.0046	0.0157	0.0142
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0074	0.0444	0.1385
Loa Loa (eye worm)	transcription factor SMAD2	0.0092	0.0633	0.0619
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.077	0.237
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0067	0.0375	0.1169
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0061
Loa Loa (eye worm)	MH2 domain-containing protein	0.0092	0.0633	0.0619
Trichomonas vaginalis	esterase, putative	0.0157	0.1292	0.5028
Trichomonas vaginalis	cyclin A, putative	0.0067	0.0375	0.14
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0166	0.1389	0.1376
Schistosoma mansoni	hypothetical protein	0.0268	0.2434	0.2423
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.1389	0.1376
Schistosoma mansoni	elongation of fatty acids protein 1	0.0069	0.0399	0.0385
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0284	0.2595	0.8093
Entamoeba histolytica	cyclin, putative	0.0067	0.0375	0.4538
Echinococcus granulosus	cyclin b3	0.0046	0.0157	0.0142
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0157	0.1292	0.1279
Trypanosoma cruzi	hypothetical protein, conserved	0.0157	0.1292	0.4035
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0284	0.2595	0.2584
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1292	0.1279
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.028	0.255	0.2539
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0034	0.0034	0.0107
Onchocerca volvulus	Elongation of very long chain fatty acids protein 5 homolog	0.0069	0.0399	0.3009
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0157	0.1292	0.1289
Leishmania major	GTP-binding protein, putative	0.007	0.0401	0.125
Giardia lamblia	Cyclin A	0.0046	0.0157	0.0642
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0166	0.1389	0.4311
Trypanosoma cruzi	PAB1-binding protein , putative	0.0039	0.0092	0.0287
Schistosoma mansoni	elongation of fatty acids protein 1	0.0069	0.0399	0.0385

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 624139