TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.515 | Formula: C22H23N5O3S
H donors: 2 H acceptors: 3 LogP: 3.03 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1NC(=O)CSc1nnc(n1CC)c1c[nH]c2c1cccc2)OC
InChi: 1S/C22H23N5O3S/c1-4-27-21(16-12-23-17-8-6-5-7-15(16)17)25-26-22(27)31-13-20(28)24-18-11-14(29-2)9-10-19(18)30-3/h5-12,23H,4,13H2,1-3H3,(H,24,28)
InChiKey: CVESTKCDVLABDE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.001	0.0225	0.0015
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.001	0.0225	0.094
Loa Loa (eye worm)	CYP4Cod1	0.001	0.0225	0.0202
Brugia malayi	Flap endonuclease-1	0.0021	0.0691	0.0669
Echinococcus granulosus	expressed conserved protein	0.009	0.3768	0.3734
Brugia malayi	N-terminal motif family protein	0.0144	0.6184	0.6175
Trypanosoma cruzi	cytochrome P450, putative	0.001	0.0225	0.0015
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.4027	0.3994
Echinococcus granulosus	segment polarity protein dishevelled	0.0007	0.0081	0.0027
Brugia malayi	Bloom's syndrome protein homolog	0.0019	0.0619	0.0596
Echinococcus granulosus	survival motor neuron protein 1	0.0229	1	1
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0049	0.1943	0.1924
Onchocerca volvulus		0.0047	0.1853	0.2969
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0048	0.1887	0.7128
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.001	0.0225	0.0015
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.0932	0.2416
Echinococcus multilocularis		0.001	0.0225	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1296	0.1276
Leishmania major	cytochrome p450-like protein	0.001	0.0225	0.0015
Loa Loa (eye worm)	RecQ helicase	0.0019	0.0619	0.0596
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.1887	0.7009
Echinococcus multilocularis	dnaJ subfamily C 6	0.0049	0.1943	0.1899
Leishmania major	cytochrome p450-like protein	0.001	0.0225	0.0015
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.1594	0.1482
Schistosoma mansoni	hypothetical protein	0.0039	0.1528	0.1563
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.1296	0.4524
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.4092	0.4282
Loa Loa (eye worm)	glutaminase	0.0218	0.9484	0.9483
Toxoplasma gondii	hypothetical protein	0.0007	0.0081	0.0184
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.1984	0.8289
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0042	0.1652	0.1606
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0042	0.1652	0.1632
Trichomonas vaginalis	DNA helicase recq1, putative	0.0019	0.0619	0.0429
Trypanosoma cruzi	cytochrome P450, putative	0.001	0.0225	0.0015
Loa Loa (eye worm)	glutaminase 2	0.0218	0.9484	0.9483
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0018	0.0586	0.1797
Echinococcus multilocularis	dna polymerase eta	0.0063	0.2558	0.2517
Onchocerca volvulus		0.0007	0.0081	0.0093
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.001	0.0225	0.094
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.001	0.0225	0.094
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.1984	0.194
Brugia malayi	Cytochrome P450 family protein	0.001	0.0225	0.0202
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0021	0.0691	0.2135
Plasmodium falciparum	DNA repair protein REV1, putative	0.0013	0.0351	0.1047
Schistosoma mansoni	dep domain containing protein	0.0007	0.0081	0.0028
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.001	0.0225	0.0015
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0007	0.0081	0.0028
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0008	0.0118	0.03
Trichomonas vaginalis	flap endonuclease-1, putative	0.0021	0.0691	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0076	0.315	0.3134
Leishmania major	DNA polymerase kappa, putative	0.0048	0.1887	0.7128
Toxoplasma gondii	cytochrome p450 superfamily protein	0.001	0.0225	0.0643
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Plasmodium vivax	ataxin-2 like protein, putative	0.002	0.0662	0.204
Echinococcus multilocularis	segment polarity protein dishevelled	0.0007	0.0081	0.0027
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0021	0.0691	0.1977
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0042	0.1652	0.6903
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0042	0.1652	0.1694
Trypanosoma brucei	chrX additional, unordered contigs	0.0013	0.0351	0.0546
Schistosoma mansoni	hypothetical protein	0.0039	0.1528	0.1563
Plasmodium falciparum	ataxin-2 like protein, putative	0.002	0.0662	0.204
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0042	0.1652	0.1632
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.001	0.0225	0.0015
Trypanosoma brucei	DNA polymerase eta, putative	0.0063	0.2558	0.9833
Mycobacterium ulcerans	hypothetical protein	0.0013	0.0351	0.0136
Loa Loa (eye worm)	MH2 domain-containing protein	0.0095	0.401	0.3996
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0144	0.6184	1
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0008	0.0118	0.0063
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.001	0.0225	0.094
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.001	0.0225	0.094
Leishmania major	DNA polymerase eta, putative	0.0033	0.1257	0.4431
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.2393	0.2342
Brugia malayi	MH2 domain containing protein	0.0095	0.401	0.3996
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1853	0.1834
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1594	0.1574
Trypanosoma cruzi	PAB1-binding protein , putative	0.002	0.0662	0.1852
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0008	0.0118	0.0063
Entamoeba histolytica	Flap nuclease, putative	0.0021	0.0691	0.1235
Leishmania major	DNA polymerase kappa, putative	0.0013	0.0351	0.0555
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Brugia malayi	polk-prov protein	0.0034	0.1296	0.1276
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.315	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0619	0.0429
Leishmania major	DNA polymerase eta, putative	0.0063	0.2558	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.1594	0.1548
Brugia malayi	Probable ClpP-like protease	0.0076	0.315	0.3134
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0008	0.0118	0.03
Echinococcus multilocularis	expressed conserved protein	0.009	0.3768	0.3734
Schistosoma mansoni	DNA helicase recq5	0.0008	0.0118	0.0067
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.001	0.0225	0.094
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.001	0.0225	0.094
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.1984	0.6014
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.1301	0.4544
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0042	0.1652	0.1694
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0042	0.1652	0.376
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0049	0.1943	0.1859
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.001	0.0225	0.094
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.001	0.0225	0.094
Trypanosoma brucei	DNA damage repair protein, putative	0.0013	0.0351	0.0546
Loa Loa (eye worm)	hypothetical protein	0.002	0.0662	0.0639
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0009	0.0167	0.0113
Trichomonas vaginalis	DNA polymerase eta, putative	0.0063	0.2598	0.2565
Echinococcus multilocularis	protein dispatched 1	0.0047	0.1852	0.1808
Brugia malayi	CHE-14 protein	0.0041	0.1594	0.1574
Echinococcus multilocularis	protein patched	0.0041	0.1594	0.1548
Schistosoma mansoni	DNA polymerase eta	0.0063	0.2558	0.2655
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.315	0.3112
Trypanosoma brucei	unspecified product	0.0058	0.2363	0.9013
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0063	0.2598	0.2565
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.4027	0.3994
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0007	0.0081	0.0058
Trypanosoma brucei	unspecified product	0.0029	0.1067	0.3557
Trypanosoma cruzi	DNA damage repair protein, putative	0.0013	0.0351	0.0546
Brugia malayi	MH2 domain containing protein	0.0006	0.0055	0.0031
Schistosoma mansoni	dishevelled	0.0007	0.0081	0.0028
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0008	0.0118	0.0094
Schistosoma mansoni	regulator of G protein signaling	0.0007	0.0081	0.0028
Schistosoma mansoni	DNA polymerase IV / kappa	0.0013	0.0351	0.0314
Loa Loa (eye worm)	flap endonuclease-1	0.0021	0.0691	0.0669
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0013	0.0336	0.0998
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.001	0.0225	0.094
Brugia malayi	glutaminase DH11.1	0.0218	0.9484	0.9483
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.2393	1
Leishmania major	hypothetical protein, conserved	0.002	0.0662	0.1884
Brugia malayi	MH1 domain containing protein	0.0006	0.0055	0.0031
Schistosoma mansoni	hypothetical protein	0.0039	0.1528	0.1563
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.315	1
Echinococcus granulosus	flap endonuclease 1	0.0021	0.0691	0.064
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.1301	0.4544
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.315	1
Plasmodium falciparum	flap endonuclease 1	0.0021	0.0691	0.2135
Trypanosoma brucei	hypothetical protein, conserved	0.0013	0.0351	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0144	0.6184	0.6175
Leishmania major	cytochrome p450-like protein	0.001	0.0225	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.002	0.0662	0.1852
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0007	0.0081	0.0058
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0063	0.2598	1
Echinococcus multilocularis	bloom syndrome protein	0.0019	0.0619	0.0567
Trypanosoma brucei	DNA polymerase IV, putative	0.0063	0.2598	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.001	0.0225	0.094
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.001	0.0225	0.094
Loa Loa (eye worm)	Smad1	0.0006	0.0055	0.0031
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.315	0.5
Brugia malayi	Cytochrome P450 family protein	0.001	0.0225	0.0202
Loa Loa (eye worm)	cytochrome P450 family protein	0.0047	0.1877	0.1857
Giardia lamblia	Flap structure-specific endonuclease	0.0021	0.0691	0.3242
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.315	1
Leishmania major	DNA damage repair protein, putative	0.0013	0.0351	0.0555
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0932	0.2903
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.1984	0.194
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0007	0.0081	0.0027
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0008	0.0118	0.0094
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Trypanosoma cruzi	DNA damage repair protein, putative	0.0013	0.0351	0.0546
Plasmodium falciparum	ataxin-2 like protein, putative	0.002	0.0662	0.204
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0225	0.0202
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0351	0.0546
Brugia malayi	Cytochrome P450 family protein	0.0047	0.1877	0.1857
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4027	0.4012
Loa Loa (eye worm)	DIX domain-containing protein	0.0007	0.0081	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0229	1	1
Schistosoma mansoni	patched 1	0.0041	0.1594	0.1633
Brugia malayi	Cytochrome P450 family protein	0.001	0.0225	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0118	0.0094
Mycobacterium ulcerans	DNA polymerase IV	0.0063	0.2598	0.2563
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0033	0.1257	0.3944
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.001	0.0225	0.094
Brugia malayi	hypothetical protein	0.002	0.0662	0.0639
Loa Loa (eye worm)	hypothetical protein	0.005	0.2005	0.1986
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.001	0.0225	0.094
Trypanosoma brucei	hypothetical protein, conserved	0.0013	0.0351	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0081	0.0058
Schistosoma mansoni	dishevelled	0.0007	0.0081	0.0028
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.315	0.3283
Loa Loa (eye worm)	transcription factor SMAD2	0.0095	0.401	0.3996
Loa Loa (eye worm)	MH2 domain-containing protein	0.0006	0.0055	0.0031
Schistosoma mansoni	hypothetical protein	0.0009	0.0167	0.012
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0932	0.2903
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0013	0.0351	0.1047
Schistosoma mansoni	hypothetical protein	0.0039	0.1528	0.1563
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.001	0.0225	0.0015
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0225	0.0202
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0008	0.0118	0.0094
Schistosoma mansoni	cytochrome P450	0.001	0.0225	0.0181
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.001	0.0225	0.094
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.1594	0.1548
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.1594	0.1574
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.5855	0.5832
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0063	0.2598	1
Brugia malayi	Smad1	0.0006	0.0055	0.0031
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.315	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.1257	0.4357
Trypanosoma brucei	PAB1-binding protein , putative	0.002	0.0662	0.1852
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.2393	0.248
Brugia malayi	cytochrome P450	0.001	0.0225	0.0202
Giardia lamblia	DNA damage repair protein	0.0013	0.0351	0.1319
Brugia malayi	MH1 domain containing protein	0.0006	0.0055	0.0031
Brugia malayi	MH2 domain containing protein	0.0006	0.0055	0.0031
Trypanosoma brucei	DNA damage repair protein, putative	0.0013	0.0351	0.0546
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.2393	0.9296
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.4027	1
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0013	0.0343	0.1019
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.1301	0.4544
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.2393	0.2342
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.2393	0.2342
Echinococcus granulosus	regulator of G protein signaling 7	0.0007	0.0081	0.0027
Echinococcus granulosus	dna polymerase kappa	0.0063	0.2598	0.2557
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0063	0.2598	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.315	0.3159
Schistosoma mansoni	hypothetical protein	0.0049	0.1943	0.2003
Mycobacterium ulcerans	DNA polymerase IV	0.0063	0.2598	0.2563
Loa Loa (eye worm)	MH1 domain-containing protein	0.0006	0.0055	0.0031
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0008	0.0118	0.03
Echinococcus granulosus	regulator of G protein signaling 7	0.0007	0.0081	0.0027
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0007	0.0081	0.0058
Trypanosoma brucei	DNA polymerase IV, putative	0.0058	0.2363	0.9013
Schistosoma mansoni	flap endonuclease-1	0.0019	0.0602	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0081	0.0058
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0017	0.0515	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2558	0.254
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0008	0.0118	0.0063
Loa Loa (eye worm)	cytochrome P450	0.001	0.0225	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0096	0.4062	0.4047
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.315	0.3159
Trichomonas vaginalis	glutaminase, putative	0.0218	0.9484	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.1984	0.8289
Schistosoma mansoni	hypothetical protein	0.001	0.0225	0.0181
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.315	0.3112
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.001	0.0225	0.094
Trypanosoma brucei	DNA polymerase IV, putative	0.0063	0.2598	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1853	0.1907
Schistosoma mansoni	DNA helicase recq1	0.0008	0.0118	0.0067
Toxoplasma gondii	hypothetical protein	0.0026	0.0932	0.2903
Trypanosoma brucei	cytochrome P450, putative	0.001	0.0225	0.0015
Echinococcus multilocularis	segment polarity protein dishevelled	0.0007	0.0081	0.0027
Mycobacterium ulcerans	glutaminase	0.0218	0.9484	1
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0021	0.0691	0.2011
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0008	0.0118	0.0063
Echinococcus granulosus	segment polarity protein dishevelled	0.0007	0.0081	0.0027
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0007	0.0081	0.0027
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0009	0.0167	0.0113
Trypanosoma brucei	unspecified product	0.0029	0.1067	0.3557
Echinococcus granulosus	dnaJ subfamily C 6	0.0049	0.1943	0.1899
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0063	0.2598	1
Brugia malayi	DIX domain containing protein	0.0007	0.0081	0.0058
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.001	0.0225	0.094
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.315	0.5
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.1594	0.1548
Brugia malayi	DnaJ domain containing protein	0.0049	0.1943	0.1924
Echinococcus multilocularis	regulator of G protein signaling 7	0.0007	0.0081	0.0027
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.315	0.5
Plasmodium vivax	flap endonuclease 1, putative	0.0021	0.0691	0.2135
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.2393	0.248
Echinococcus granulosus	dna polymerase eta	0.0063	0.2558	0.2517
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0007	0.0081	0.0093
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.001	0.0225	0.094
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.1296	0.4524
Schistosoma mansoni	blooms syndrome DNA helicase	0.0015	0.0439	0.0408
Giardia lamblia	DINP protein human, muc B family	0.0048	0.1887	1
Echinococcus multilocularis	dna polymerase kappa	0.0063	0.2598	0.2557
Schistosoma mansoni	z-protein (S1r protein)	0.0007	0.0081	0.0028
Schistosoma mansoni	hypothetical protein	0.0047	0.1853	0.1907
Brugia malayi	hypothetical protein	0.0013	0.0344	0.0321
Brugia malayi	regulator of G-protein signaling egl-10	0.0007	0.0081	0.0058
Brugia malayi	hypothetical protein	0.0007	0.0081	0.0058
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.001	0.0225	0.094
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0042	0.1652	0.1606
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0081	0.0058
Brugia malayi	ImpB/MucB/SamB family protein	0.0063	0.2558	0.254
Echinococcus multilocularis	flap endonuclease 1	0.0021	0.0691	0.064
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.5855	0.5832
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0351	0.0546
Schistosoma mansoni	glutaminase	0.0218	0.9484	1
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0021	0.0691	0.1977
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.2393	0.758
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.2393	0.2352
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.315	1
Echinococcus granulosus	bloom syndrome protein	0.0019	0.0619	0.0567
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.4027	0.4012
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.2393	0.2352
Plasmodium vivax	DNA repair protein REV1, putative	0.0013	0.0351	0.1047
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.2598	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.001	0.0225	0.094
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0048	0.1887	0.7883
Toxoplasma gondii	LsmAD domain-containing protein	0.002	0.0662	0.204
Echinococcus multilocularis	regulator of G protein signaling 7	0.0007	0.0081	0.0027
Brugia malayi	hypothetical protein	0.0007	0.0081	0.0058
Trypanosoma cruzi	DNA polymerase eta, putative	0.0063	0.2558	0.9833
Echinococcus granulosus	cytochrome P450 2K1	0.001	0.0225	0.0171

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 624397