Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0092 | 0.3565 | 0.3499 |
Echinococcus multilocularis | geminin | 0.0166 | 0.8025 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.5094 | 0.5044 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0212 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0784 | 0.0862 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0212 | 0.5 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.01 | 0.405 | 0.5 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.01 | 0.405 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0784 | 0.069 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0092 | 0.3565 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.01 | 0.405 | 0.5 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.405 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.5094 | 0.5044 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.8005 | 0.9976 |
Echinococcus granulosus | geminin | 0.0166 | 0.8025 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.5094 | 0.5044 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0784 | 0.069 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.8025 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0212 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.8025 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.8005 | 0.9976 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0212 | 0.014 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0092 | 0.3565 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0784 | 0.0732 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0092 | 0.3565 | 0.4291 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0212 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.405 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0092 | 0.3565 | 0.3499 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0784 | 0.0732 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0784 | 0.0862 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1024 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 1 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.01 | 0.405 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0092 | 0.3565 | 0.4291 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0212 | 0.0112 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0784 | 0.0862 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0784 | 0.0732 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0092 | 0.3565 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0212 | 0.014 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0784 | 0.0732 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0092 | 0.3565 | 0.4371 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0092 | 0.3565 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0092 | 0.3565 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1024 | 0.0933 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0092 | 0.3565 | 0.5 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.01 | 0.405 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.