Detailed information for compound 624766

Basic information

Technical information
  • TDR Targets ID: 624766
  • Name: N-[3-(6-methyl-4-phenylquinolin-2-yl)phenyl]m ethanesulfonamide
  • MW: 388.482 | Formula: C23H20N2O2S
  • H donors: 1 H acceptors: 3 LogP: 4.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c(cc(n2)c1cccc(c1)NS(=O)(=O)C)c1ccccc1
  • InChi: 1S/C23H20N2O2S/c1-16-11-12-22-21(13-16)20(17-7-4-3-5-8-17)15-23(24-22)18-9-6-10-19(14-18)25-28(2,26)27/h3-15,25H,1-2H3
  • InChiKey: KQXKBCNHGQUWOB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[3-(6-methyl-4-phenyl-2-quinolyl)phenyl]methanesulfonamide
  • N-[3-(6-methyl-4-phenyl-quinolin-2-yl)phenyl]methanesulfonamide
  • MLS000697296
  • SMR000237936

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein 84, putative 0.0037 0.061 0.5247
Schistosoma mansoni cpg binding protein 0.0029 0.042 0.042
Schistosoma mansoni heat shock protein 0.0055 0.1072 0.1072
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.153 0.153
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.1072 1
Schistosoma mansoni lamin 0.0033 0.0506 0.0506
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0782 0.0782
Onchocerca volvulus 0.0114 0.2525 0.7208
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Schistosoma mansoni heat shock protein 0.0037 0.061 0.061
Brugia malayi PHD-finger family protein 0.0032 0.0486 0.1059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0224 0.0489
Loa Loa (eye worm) hypothetical protein 0.0015 0.0072 0.0158
Onchocerca volvulus 0.0033 0.0506 0.1445
Toxoplasma gondii Hsp90 domain-containing protein 0.021 0.4909 1
Echinococcus granulosus lamin 0.0033 0.0506 0.0506
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0047 0.0873 0.0873
Echinococcus granulosus GPCR family 2 0.0019 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.022
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.1072 1
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0072 0.0158
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.3778 0.3778
Brugia malayi Bromodomain containing protein 0.0046 0.0846 0.1845
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.1072 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0782 0.7012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.013 0.0284
Loa Loa (eye worm) hypothetical protein 0.0085 0.1819 0.3967
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0873 0.7954
Brugia malayi Endoplasmin precursor 0.0055 0.1072 0.2337
Trypanosoma brucei heat shock protein, putative 0.0055 0.1072 1
Plasmodium vivax endoplasmin, putative 0.0055 0.1072 0.1074
Echinococcus multilocularis lamin dm0 0.0033 0.0506 0.0506
Schistosoma mansoni hypothetical protein 0.0025 0.0316 0.0316
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0782 0.7012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.4587 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0156 0.0567
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0019 0.017 0.017
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0316 0.0689
Echinococcus multilocularis muscleblind protein 0.016 0.3682 0.3682
Brugia malayi Muscleblind-like protein 0.016 0.3682 0.8028
Schistosoma mansoni cpg binding protein 0.0033 0.0519 0.0519
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.042 0.0916
Schistosoma mansoni heat shock protein 0.0055 0.1072 0.1072
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1072 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0782 0.7012
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0037 0.061 0.5247
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0224 0.0224
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.1072 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0919 0.2004
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Echinococcus multilocularis heat shock protein 90 0.0047 0.0873 0.0873
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0227 0.0495
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0987 0.5
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Echinococcus multilocularis heat shock protein 90 0.0055 0.1072 0.1072
Echinococcus multilocularis dnaJ subfamily B 0.0415 1 1
Echinococcus granulosus lamin dm0 0.0033 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0153 0.3503 0.7638
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1072 1
Plasmodium falciparum endoplasmin, putative 0.004 0.0695 0.045
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0719 0.1569
Echinococcus granulosus endoplasmin 0.0052 0.0987 0.0987
Brugia malayi Latrophilin receptor protein 2 0.0019 0.017 0.0371
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.013 0.0284
Echinococcus multilocularis muscleblind protein 1 0.016 0.3682 0.3682
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.017 0.017
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0782 0.7012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0506 0.1103
Loa Loa (eye worm) hypothetical protein 0.0032 0.0491 0.1071
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0987 0.5
Trypanosoma brucei heat shock protein, putative 0.0055 0.1072 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.017 0.0371
Schistosoma mansoni cpg binding protein 0.0033 0.0519 0.0519
Loa Loa (eye worm) heat shock protein 75 0.0037 0.061 0.1331
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.019
Echinococcus multilocularis GPCR, family 2 0.0019 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0019 0.017 0.017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.017 0.0371
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0987 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0224 0.0224
Schistosoma mansoni alpha-glucosidase 0.0169 0.3906 0.3906
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0224 0.0224
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0415 0.0415
Leishmania major heat shock protein, putative 0.0037 0.061 0.5247
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1138 0.1228
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.2987 0.6513
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.3475 0.3475
Schistosoma mansoni thyroid hormone receptor 0.0164 0.3778 0.3778
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4587 0.4587
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.1072 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1193 0.2601
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Schistosoma mansoni endoplasmin 0.0055 0.1072 0.1072
Echinococcus multilocularis lamin 0.0033 0.0506 0.0506
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0782 0.7012
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0272 0.1768
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0041 0.0719 0.0719
Loa Loa (eye worm) endoplasmin 0.0055 0.1072 0.2337
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.017 0.017
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0208 0.0208
Schistosoma mansoni alpha glucosidase 0.0044 0.0782 0.0782
Echinococcus granulosus muscleblind protein 0.016 0.3682 0.3682
Echinococcus multilocularis endoplasmin 0.0052 0.0987 0.0987
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0782 0.7012
Loa Loa (eye worm) hypothetical protein 0.0053 0.1018 0.2219
Onchocerca volvulus 0.0033 0.0506 0.1445
Schistosoma mansoni hypothetical protein 0.0415 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0782 0.1704
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0087 0.0087
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0782 0.7012
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0224 0.0224
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.1072 0.1074
Plasmodium vivax heat shock protein, putative 0.021 0.4909 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0782 0.7012
Echinococcus granulosus heat shock protein 0.0055 0.1072 0.1072
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0873 0.7954
Trichomonas vaginalis endoplasmin, putative 0.004 0.0695 0.6117
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0208 0.0208
Schistosoma mansoni zinc finger protein 0.0018 0.0156 0.0156
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0775 0.0775
Schistosoma mansoni thyroid hormone receptor 0.0164 0.3778 0.3778
Trypanosoma brucei ISWI complex protein 0.0018 0.0156 0.0567
Trypanosoma brucei glucosidase, putative 0.0044 0.0782 0.7012
Trypanosoma brucei heat shock protein, putative 0.0055 0.1072 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1193 0.2601
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0782 0.7012
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0037 0.061 0.061
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.1072 1
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.2987 0.6513
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0987 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0782 0.7012
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0987 0.913
Onchocerca volvulus 0.0029 0.042 0.1199
Onchocerca volvulus 0.0153 0.3503 1
Treponema pallidum heat shock protein 90 0.0052 0.0987 0.5
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0496 0.4071
Toxoplasma gondii heat shock protein HSP90 0.0055 0.1072 0.1074
Plasmodium vivax heat shock protein 86, putative 0.0055 0.1072 0.1074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0506 0.1103
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0987 0.913
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0782 0.7012
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0037 0.061 0.061
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0208 0.0208
Schistosoma mansoni alpha-glucosidase 0.0169 0.3906 0.3906
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.153 0.153
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0037 0.061 0.1742
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0101 0.0288
Trypanosoma brucei heat shock protein, putative 0.0055 0.1072 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.1072 1
Echinococcus granulosus heat shock protein 90 0.0055 0.1072 0.1072
Echinococcus multilocularis heat shock protein 0.0055 0.1072 0.1072
Schistosoma mansoni intermediate filament proteins 0.0033 0.0506 0.0506
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0208 0.0208
Trypanosoma brucei heat shock protein, putative 0.0055 0.1072 1
Plasmodium falciparum heat shock protein 90, putative 0.021 0.4909 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0506 0.1103
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1072 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0415 0.0415
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.4587 1
Schistosoma mansoni zinc finger protein 0.0025 0.0325 0.0325
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0101 0.022
Trypanosoma cruzi heat shock protein, putative 0.0037 0.061 0.5247
Echinococcus multilocularis zinc finger protein 0.0025 0.0325 0.0325
Brugia malayi Hsp90 protein 0.0037 0.061 0.1331
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1231 0.1231
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0415 0.0415
Trichomonas vaginalis heat shock protein, putative 0.0055 0.1072 1
Brugia malayi Bromodomain containing protein 0.0092 0.1989 0.4336
Echinococcus granulosus intermediate filament protein 0.0033 0.0506 0.0506
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0782 0.0399
Brugia malayi hypothetical protein 0.0153 0.3503 0.7638
Brugia malayi MH2 domain containing protein 0.0132 0.2987 0.6513
Schistosoma mansoni hypothetical protein 0.0152 0.3475 0.3475
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0371
Echinococcus multilocularis musashi 0.0033 0.0506 0.0506
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0782 0.7012
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0782 0.7012
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4587 0.4587
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1193 0.2601
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.1072 1
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.1072 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.3475 0.3475
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0987 0.913
Schistosoma mansoni endoplasmin 0.0055 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.016 0.3682 0.8028
Giardia lamblia Grp94/Hsp90 0.0052 0.0987 0.5748
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0782 0.1704
Echinococcus granulosus cpg binding protein 0.0033 0.0519 0.0519
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0519 0.0519
Trypanosoma brucei heat shock protein, putative 0.0055 0.1072 1
Echinococcus granulosus zinc finger protein 0.0025 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.016 0.3682 0.8028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0848 0.1849
Trichomonas vaginalis heat shock protein, putative 0.004 0.0695 0.6117
Brugia malayi intermediate filament protein 0.0033 0.0506 0.1103
Schistosoma mansoni bromodomain containing protein 0.0078 0.1637 0.1637
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0775 0.0775
Brugia malayi heat shock protein 90 0.0055 0.1072 0.2337
Loa Loa (eye worm) heat shock protein 90 0.0055 0.1072 0.2337
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0873 0.7954
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0782 0.7012
Echinococcus granulosus heat shock protein 90 0.0047 0.0873 0.0873
Brugia malayi CXXC zinc finger family protein 0.0029 0.042 0.0916
Trypanosoma brucei heat shock protein, putative 0.0055 0.1072 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0506 0.1103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1193 0.2601
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0782 0.0782
Leishmania major heat shock protein 83-1 0.0055 0.1072 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0019 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0018 0.0156 0.0156
Leishmania major hypothetical protein, conserved 0.0018 0.0156 0.0567
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.4587 0.4587
Schistosoma mansoni hypothetical protein 0.0019 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0041 0.0719 0.1569
Trypanosoma cruzi ISWI complex protein 0.0018 0.0156 0.0567
Schistosoma mansoni lamin 0.0033 0.0506 0.0506
Plasmodium falciparum heat shock protein 90 0.0055 0.1072 0.1305

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 4.754 uM PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 9.598 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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