Detailed information for compound 624817

Basic information

Technical information
  • TDR Targets ID: 624817
  • Name: 5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]- 3-phenyltriazol-4-amine
  • MW: 334.332 | Formula: C17H14N6O2
  • H donors: 1 H acceptors: 4 LogP: 2.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1noc(n1)c1nnn(c1N)c1ccccc1
  • InChi: 1S/C17H14N6O2/c1-24-13-9-7-11(8-10-13)16-19-17(25-21-16)14-15(18)23(22-20-14)12-5-3-2-4-6-12/h2-10H,18H2,1H3
  • InChiKey: WTIPLRUVRBKQMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-3-phenyl-triazol-4-amine
  • 5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-3-phenyl-4-triazolamine
  • [5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-3-phenyl-triazol-4-yl]amine
  • 5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-3-phenyl-1,2,3-triazol-4-amine
  • ZINC02713072

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0032 0.1444 0.1632
Schistosoma mansoni hypothetical protein 0.0031 0.1339 0.1339
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Brugia malayi RNA binding protein 0.0062 0.333 0.3764
Schistosoma mansoni tar DNA-binding protein 0.0062 0.333 0.333
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.5641 0.6376
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.1444 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Schistosoma mansoni hypothetical protein 0.0067 0.365 0.365
Loa Loa (eye worm) intermediate filament protein 0.0026 0.1043 0.1179
Leishmania major prostaglandin f synthase, putative 0.0032 0.1444 1
Brugia malayi TAR-binding protein 0.0062 0.333 0.3764
Loa Loa (eye worm) hypothetical protein 0.0031 0.1339 0.1513
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.1444 0.1632
Echinococcus multilocularis aldo keto reductase 0.0032 0.1444 0.1444
Toxoplasma gondii aldose reductase, putative 0.0032 0.1444 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0152
Schistosoma mansoni hypothetical protein 0.0165 1 1
Onchocerca volvulus 0.0032 0.1444 0.1632
Schistosoma mansoni tar DNA-binding protein 0.0062 0.333 0.333
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.5641 0.6376
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.1444 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Trypanosoma cruzi aldo-keto reductase 0.0032 0.1444 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.333 0.333
Schistosoma mansoni intermediate filament proteins 0.0026 0.1043 0.1043
Loa Loa (eye worm) RNA binding protein 0.0062 0.333 0.3764
Giardia lamblia Aldose reductase 0.0032 0.1444 0.5
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0255 0.0289
Loa Loa (eye worm) oxidoreductase 0.0032 0.1444 0.1632
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0165 0.0165
Mycobacterium ulcerans oxidoreductase 0.0032 0.1444 0.5
Schistosoma mansoni aldo-keto reductase 0.0032 0.1444 0.1444
Loa Loa (eye worm) oxidoreductase 0.0032 0.1444 0.1632
Echinococcus multilocularis GPCR, family 2 0.0031 0.1339 0.1339
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0032 0.1444 1
Echinococcus multilocularis lamin dm0 0.0026 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0165 0.0187
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.1339 0.1339
Onchocerca volvulus 0.0032 0.1444 0.1632
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0 0.5
Loa Loa (eye worm) oxidoreductase 0.0032 0.1444 0.1632
Echinococcus granulosus aldo keto reductase 0.0032 0.1444 0.1444
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.1444 0.1632
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.1444 1
Echinococcus granulosus intermediate filament protein 0.0026 0.1043 0.1043
Echinococcus granulosus aldehyde reductase 0.0023 0.0837 0.0837
Schistosoma mansoni pol-related 0.0032 0.1444 0.1444
Loa Loa (eye worm) hypothetical protein 0.0097 0.5641 0.6376
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Brugia malayi hypothetical protein 0.0147 0.8847 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Onchocerca volvulus 0.0032 0.1444 0.1632
Entamoeba histolytica aldose reductase, putative 0.0032 0.1444 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.1444 0.1444
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Entamoeba histolytica aldose reductase, putative 0.0032 0.1444 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0032 0.1444 0.5
Trypanosoma brucei aldo-keto reductase, putative 0.0032 0.1444 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0255 0.0289
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Loa Loa (eye worm) hypothetical protein 0.0026 0.1012 0.1143
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.1444 1
Trypanosoma brucei prostaglandin f synthase 0.0032 0.1444 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.5641 0.6376
Onchocerca volvulus 0.0026 0.1043 0.1179
Echinococcus granulosus lamin 0.0026 0.1043 0.1043
Echinococcus granulosus GPCR family 2 0.0031 0.1339 0.1339
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0165 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1444 0.1632
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Echinococcus granulosus hypothetical protein 0.0032 0.1444 0.1444
Onchocerca volvulus 0.0032 0.1444 0.1632
Echinococcus multilocularis musashi 0.0026 0.1043 0.1043
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.1444 0.1632
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.1339 0.1339
Schistosoma mansoni tar DNA-binding protein 0.0062 0.333 0.333
Onchocerca volvulus 0.0147 0.8847 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Brugia malayi intermediate filament protein 0.0026 0.1043 0.1179
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.1444 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.365 0.4125
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Schistosoma mansoni hypothetical protein 0.0165 1 1
Echinococcus granulosus lamin dm0 0.0026 0.1043 0.1043
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Echinococcus granulosus aldo keto reductase 0.0032 0.1444 0.1444
Echinococcus granulosus aldo keto reductase 0.0032 0.1444 0.1444
Onchocerca volvulus 0.0032 0.1444 0.1632
Loa Loa (eye worm) TAR-binding protein 0.0062 0.333 0.3764
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.1444 0.1632
Onchocerca volvulus 0.0032 0.1444 0.1632
Loa Loa (eye worm) hypothetical protein 0.0147 0.8847 1
Echinococcus multilocularis aldehyde reductase 0.0023 0.0837 0.0837
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.333 0.3764
Plasmodium falciparum multidrug resistance protein 1 0.001 0 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.365 0.4125
Leishmania major aldo-keto reductase-like protein 0.0032 0.1444 1
Schistosoma mansoni aldo-keto reductase 0.0032 0.1444 0.1444
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.333 0.3764
Echinococcus multilocularis tar DNA binding protein 0.0062 0.333 0.333
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.001 0 0.5
Entamoeba histolytica aldose reductase, putative 0.0032 0.1444 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0032 0.1444 1
Schistosoma mansoni hypothetical protein 0.0031 0.1339 0.1339
Echinococcus granulosus tar DNA binding protein 0.0062 0.333 0.333
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.1444 1
Onchocerca volvulus 0.0026 0.1043 0.1179
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.1339 0.1513
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.333 0.333
Schistosoma mansoni hypothetical protein 0.0031 0.1339 0.1339
Loa Loa (eye worm) hypothetical protein 0.0026 0.1043 0.1179
Echinococcus multilocularis geminin 0.0165 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.1339 0.1513
Schistosoma mansoni lamin 0.0026 0.1043 0.1043
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.1043 0.1179
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.1339 0.1339
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1444 0.1444
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1444 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.1339 0.1513
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.1444 1
Giardia lamblia Aldose reductase 0.0032 0.1444 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1444 0.1444
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0032 0.1444 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.1444 0.1444
Echinococcus multilocularis aldo keto reductase 0.0032 0.1444 0.1444
Loa Loa (eye worm) oxidoreductase 0.0032 0.1444 0.1632
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.1043 0.1179
Schistosoma mansoni lamin 0.0026 0.1043 0.1043
Echinococcus multilocularis lamin 0.0026 0.1043 0.1043
Schistosoma mansoni hypothetical protein 0.0031 0.1339 0.1339
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0152
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.1339 0.1339

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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