Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0703 | 0.8161 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0178 | 0.1571 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0703 | 0.8161 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0271 | 0.2738 | 0.3355 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0269 | 0.2716 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.1691 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.2738 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.2738 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0703 | 0.8161 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0269 | 0.2716 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.2738 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0703 | 0.8161 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0269 | 0.2716 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0271 | 0.2738 | 0.3355 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.2738 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.2738 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0269 | 0.2716 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0703 | 0.8161 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 0.2738 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0703 | 0.8161 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0703 | 0.8161 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0269 | 0.2716 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0703 | 0.8161 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.1691 | 0.1027 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0269 | 0.2716 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0703 | 0.8161 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.