Detailed information for compound 625101

Basic information

Technical information
  • TDR Targets ID: 625101
  • Name: 2-fluoro-N-[[4-(4-nitrophenyl)-5-sulfanyliden e-1H-1,2,4-triazol-3-yl]methyl]benzamide
  • MW: 373.362 | Formula: C16H12FN5O3S
  • H donors: 1 H acceptors: 5 LogP: 2.31 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1F)NCc1nnc(n1c1ccc(cc1)[N+](=O)[O-])S
  • InChi: 1S/C16H12FN5O3S/c17-13-4-2-1-3-12(13)15(23)18-9-14-19-20-16(26)21(14)10-5-7-11(8-6-10)22(24)25/h1-8H,9H2,(H,18,23)(H,20,26)
  • InChiKey: IBPDGKKSLKMZBC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-fluoro-N-[[4-(4-nitrophenyl)-5-thioxo-1H-1,2,4-triazol-3-yl]methyl]benzamide
  • ZINC04059208
  • Oprea1_367994

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis AMP nucleosidase 0.0118 0.1826 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0506 0.0506
Echinococcus multilocularis smad 0.0033 0.0292 0.0292
Treponema pallidum pfs protein (pfs) 0.0118 0.1826 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1646 0.1146
Schistosoma mansoni uridine phosphorylase 0.0118 0.1826 0.1826
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0565 0.2906
Loa Loa (eye worm) hypothetical protein 0.0072 0.0992 0.1166
Mycobacterium tuberculosis Hypothetical protein 0.0118 0.1826 0.1786
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0565 0.0543
Trichomonas vaginalis ran, putative 0.0022 0.0079 0.0031
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1908 0.1908
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0992 0.5312
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1864 0.1377
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.1633 0.1633
Brugia malayi MH1 domain containing protein 0.0033 0.0292 0.0269
Schistosoma mansoni methylthioadenosine phosphorylase 0.0118 0.1826 0.1826
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0404
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0308 0.0261
Echinococcus multilocularis geminin 0.018 0.2949 0.2949
Echinococcus granulosus purine nucleoside phosphorylase 0.0571 1 1
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0118 0.1826 0.1786
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0118 0.1826 0.2145
Schistosoma mansoni hypothetical protein 0.018 0.2949 0.2949
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0565 0.0519
Giardia lamblia UPL-1 0.0118 0.1826 0.1786
Brugia malayi glutathione reductase 0.0047 0.0548 0.0526
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0565 0.0519
Mycobacterium leprae Probable lipase LipE 0.0072 0.0992 0.0453
Brugia malayi PHD-finger family protein 0.0025 0.0142 0.0119
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0292 0.0343
Brugia malayi Ets-domain containing protein 0.0071 0.0966 0.0945
Brugia malayi Smad1 0.0033 0.0292 0.0269
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0992 0.0949
Schistosoma mansoni ap endonuclease 0.002 0.0048 0.0048
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0571 1 1
Mycobacterium leprae probable uridine phosphorylase 0.0118 0.1826 0.1336
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0079 0.0031
Trichomonas vaginalis esterase, putative 0.0072 0.0992 0.0949
Mycobacterium tuberculosis Conserved protein 0.0072 0.0992 0.0949
Leishmania major hypothetical protein, conserved 0.005 0.0599 0.3101
Entamoeba histolytica hypothetical protein 0.0024 0.0119 0.0395
Mycobacterium ulcerans hypothetical protein 0.0048 0.0565 0.0519
Leishmania major GTP-binding protein, putative 0.0022 0.0079 0.0173
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0992 0.0949
Loa Loa (eye worm) hypothetical protein 0.0041 0.0429 0.0504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0308 0.0261
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0565 0.2906
Loa Loa (eye worm) hypothetical protein 0.0029 0.0218 0.0257
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0065 0.0076
Plasmodium falciparum thioredoxin reductase 0.0047 0.0548 0.2811
Loa Loa (eye worm) nuclear factor I 0.0018 0.0023 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0489 0.8512 1
Schistosoma mansoni hypothetical protein 0.0312 0.5322 0.5322
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0079 0.0173
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0118 0.1826 0.1786
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0218 0.0218
Plasmodium vivax importin-beta 2, putative 0.0029 0.0218 0.0957
Brugia malayi hypothetical protein 0.0108 0.1633 0.1613
Echinococcus granulosus smad 0.0033 0.0292 0.0292
Schistosoma mansoni purine nucleoside phosphorylase 0.0571 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0118 0.1826 0.1786
Brugia malayi Bromodomain containing protein 0.0075 0.105 0.1029
Echinococcus multilocularis purine nucleoside phosphorylase 0.0571 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0599 0.3101
Echinococcus multilocularis purine nucleoside phosphorylase 0.0571 1 1
Toxoplasma gondii Purine nucleoside phosphorylase 0.0118 0.1826 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0565 0.2906
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0118 0.1826 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0562 0.066
Plasmodium vivax glutathione reductase, putative 0.0047 0.0548 0.2811
Echinococcus granulosus purine nucleoside phosphorylase 0.0571 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0218 0.0957
Schistosoma mansoni methylthioadenosine phosphorylase 0.0118 0.1826 0.1826
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0027
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0118 0.1826 1
Schistosoma mansoni hypothetical protein 0.018 0.2949 0.2949
Mycobacterium ulcerans lipase LipD 0.0072 0.0992 0.0949
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0599 0.3101
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0966 0.1135
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0404
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.01 0.01
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0098 0.0098
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0565 0.0519
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0992 0.0949
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.5322 0.6253
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0992 0.0949
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1646 0.1605
Plasmodium falciparum importin beta, putative 0.0029 0.0218 0.0957
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0048 0.0025
Loa Loa (eye worm) glutathione reductase 0.0047 0.0548 0.0644
Echinococcus multilocularis snurportin 1 0.0312 0.5322 0.5322
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0565 0.2906
Schistosoma mansoni thyroid hormone receptor 0.0133 0.2086 0.2086
Entamoeba histolytica hypothetical protein 0.0108 0.1633 0.8915
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0079 0.0173
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0118 0.1826 0.1786
Brugia malayi Importin beta-1 subunit 0.0029 0.0218 0.0196
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0021 0.0065 0.0065
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0118 0.1826 0.1786
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0119 0.0395
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0118 0.1826 0.1786
Leishmania major trypanothione reductase 0.0047 0.0548 0.2811
Brugia malayi MTAP 0.0118 0.1826 0.1807
Loa Loa (eye worm) Smad1 0.0033 0.0292 0.0343
Schistosoma mansoni hypothetical protein 0.0097 0.1441 0.1441
Toxoplasma gondii thioredoxin reductase 0.0047 0.0548 0.2811
Leishmania major hypothetical protein, conserved 0.0072 0.0992 0.5312
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0565 0.0519
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0118 0.1826 0.1786
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.01 0.01
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0548 0.0644
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0599 0.3101
Mycobacterium tuberculosis Conserved protein 0.0072 0.0992 0.0949
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1646 0.1605
Entamoeba histolytica hypothetical protein 0.0118 0.1826 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0344 0.0297
Entamoeba histolytica hypothetical protein 0.0108 0.1633 0.8915
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0992 0.0949
Echinococcus multilocularis purine nucleoside phosphorylase 0.0571 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0992 0.0949
Schistosoma mansoni ets-related 0.0214 0.3564 0.3564
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0599 0.3101
Echinococcus multilocularis purine nucleoside phosphorylase 0.0571 1 1
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0571 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0599 0.3101
Schistosoma mansoni zinc finger protein 0.002 0.0046 0.0046
Echinococcus granulosus importin subunit beta 1 0.0029 0.0218 0.0218
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0565 0.0519
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1864 0.1825
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.1826 0.1786
Brugia malayi Thioredoxin reductase 0.0047 0.0548 0.0526
Brugia malayi hypothetical protein 0.0032 0.0277 0.0255
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0992 0.0949
Echinococcus multilocularis uridine phosphorylase 1 0.0118 0.1826 0.1826
Brugia malayi Fli-1 protein 0.0214 0.3564 0.3549
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0292 0.0292
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0292 0.0292
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0992 0.0992
Echinococcus granulosus purine nucleoside phosphorylase 0.0571 1 1
Loa Loa (eye worm) beta-lactamase 0.0072 0.0992 0.1166
Schistosoma mansoni ap endonuclease 0.002 0.0048 0.0048
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0218 0.0957
Treponema pallidum uridine phosphorylase (udp) 0.0118 0.1826 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0506 0.0484
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1864 0.1825
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0565 0.0519
Brugia malayi hypothetical protein 0.005 0.0599 0.0578
Brugia malayi MH2 domain containing protein 0.0489 0.8512 0.8508
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0079 0.0173
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0118 0.1826 0.1786
Plasmodium falciparum glutathione reductase 0.0047 0.0548 0.2811
Schistosoma mansoni bromodomain containing protein 0.0064 0.0838 0.0838
Schistosoma mansoni gabp alpha 0.0071 0.0966 0.0966
Loa Loa (eye worm) hypothetical protein 0.0453 0.7865 0.9241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0506 0.0506
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0048 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0992 0.5312
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0344 0.1663
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0404
Brugia malayi beta-lactamase family protein 0.0072 0.0992 0.0971
Brugia malayi MH1 domain containing protein 0.0033 0.0292 0.0269
Loa Loa (eye worm) hypothetical protein 0.0043 0.0464 0.0545
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0118 0.1826 0.1786
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0079 0.0093
Mycobacterium ulcerans hypothetical protein 0.0072 0.0992 0.0949
Onchocerca volvulus 0.0072 0.0992 0.0456
Loa Loa (eye worm) hypothetical protein 0.0072 0.0992 0.1166
Echinococcus granulosus uridine phosphorylase 1 0.0118 0.1826 0.1826
Loa Loa (eye worm) hypothetical protein 0.0072 0.0992 0.1166
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.1826 0.1786
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0118 0.1826 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0079 0.0079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.005 0.0599 0.0704
Echinococcus granulosus snurportin 1 0.0312 0.5322 0.5322
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0992 0.1166
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0506 0.0595
Schistosoma mansoni Smad4 0.0033 0.0292 0.0292
Loa Loa (eye worm) uridine phosphorylase 0.0118 0.1826 0.2145
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0562 0.0562
Echinococcus multilocularis tumor protein p63 0.033 0.5643 0.5643
Echinococcus granulosus purine nucleoside phosphorylase 0.0571 1 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0565 0.0543
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0119 0.0071
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0118 0.1826 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0548 0.0502
Echinococcus granulosus methylthioadenosine phosphorylase 0.0118 0.1826 0.1826
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0344 0.0297
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0342 0.0342
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0118 0.1826 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0118 0.1826 1
Loa Loa (eye worm) fli-1 protein 0.0214 0.3564 0.4187
Brugia malayi Bromodomain containing protein 0.0038 0.0385 0.0363
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0079 0.0056
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.8006 0.7997
Entamoeba histolytica hypothetical protein 0.0108 0.1633 0.8915
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0292 0.0343
Schistosoma mansoni thyroid hormone receptor 0.0133 0.2086 0.2086
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.01 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0565 0.0519
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1908 0.1908
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1646 0.1605
Echinococcus granulosus geminin 0.018 0.2949 0.2949
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0344 0.1663
Echinococcus granulosus zinc finger protein 0.002 0.0046 0.0046
Onchocerca volvulus 0.0048 0.0565 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0048 0.5
Toxoplasma gondii ABC1 family protein 0.0072 0.0992 0.5312
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0011 0.0013
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.8273 0.8273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0308 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.1826 0.1786
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0565 0.2906
Brugia malayi beta-lactamase 0.0072 0.0992 0.0971
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0571 1 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0118 0.1826 1
Leishmania major nucleoside phosphorylase-like protein 0.0118 0.1826 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0506 0.0506
Schistosoma mansoni ran 0.0022 0.0079 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0992 0.5312
Schistosoma mansoni ran 0.0022 0.0079 0.0079
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0565 0.2906
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0992 0.0949
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.2086 0.2086
Schistosoma mansoni smad1 5 8 and 0.0033 0.0292 0.0292
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0992 0.0971
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0404
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1864 0.1825
Echinococcus granulosus purine nucleoside phosphorylase 0.0571 1 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0571 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0992 0.0992
Loa Loa (eye worm) hypothetical protein 0.0048 0.0565 0.0664
Schistosoma mansoni smad1 5 8 and 0.0033 0.0292 0.0292
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0118 0.1826 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0992 0.0949
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0548 0.2811
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0571 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0118 0.1826 0.1786
Brugia malayi beta-lactamase family protein 0.0072 0.0992 0.0971
Loa Loa (eye worm) hypothetical protein 0.0072 0.0992 0.1166
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0565 0.0519
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0548 0.2811
Echinococcus multilocularis zinc finger protein 0.002 0.0046 0.0046
Schistosoma mansoni smad 0.0033 0.0292 0.0292
Toxoplasma gondii phosphorylase family protein 0.0118 0.1826 1
Schistosoma mansoni hypothetical protein 0.0108 0.1633 0.1633
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0453 0.7865 0.7865
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1441 0.1421
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0292 0.0292
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0773 0.0773
Schistosoma mansoni purine nucleoside phosphorylase 0.0571 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0599 0.3101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0506 0.0506
Echinococcus granulosus purine nucleoside phosphorylase 0.0571 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.1633 0.1633
Entamoeba histolytica Ran family GTPase 0.0022 0.0079 0.0173
Trypanosoma brucei trypanothione reductase 0.0047 0.0548 0.2811
Echinococcus multilocularis purine nucleoside phosphorylase 0.0571 1 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0098 0.0098
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0548 0.0548
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0966 0.0966
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0119 0.0071
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0118 0.1826 0.1786
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0292 0.0292
Onchocerca volvulus 0.0097 0.1441 0.0932
Loa Loa (eye worm) hypothetical protein 0.0072 0.0992 0.1166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0506 0.0506
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0292 0.0292
Mycobacterium tuberculosis Probable reductase 0.0108 0.1646 0.1605
Mycobacterium ulcerans beta-lactamase 0.0072 0.0992 0.0949
Echinococcus multilocularis purine nucleoside phosphorylase 0.0453 0.7865 0.7865
Leishmania major importin beta-1 subunit, putative 0.0024 0.0119 0.0395
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0048 0.0565 0.0664
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0992 0.0949
Brugia malayi Ets-domain containing protein 0.0071 0.0966 0.0945
Loa Loa (eye worm) hypothetical protein 0.0475 0.8273 0.972
Loa Loa (eye worm) hypothetical protein 0.0039 0.0386 0.0454
Brugia malayi RNA, U transporter 1 0.0083 0.1191 0.117
Plasmodium falciparum purine nucleoside phosphorylase 0.0118 0.1826 1
Echinococcus granulosus Smad4 0.0033 0.0292 0.0292
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0118 0.1826 1
Brugia malayi uridine phosphorylase family protein 0.0118 0.1826 0.1807
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0506 0.0506
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0218 0.0957
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0992 0.0949
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1646 0.1605
Brugia malayi MH2 domain containing protein 0.0033 0.0292 0.0269
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0118 0.1826 0.1826
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0308 0.0261
Toxoplasma gondii phosphorylase family protein 0.0118 0.1826 1
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0118 0.1826 0.1786
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.8273 0.8273
Schistosoma mansoni importin beta-1 0.0029 0.0218 0.0218
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0108 0.1633 0.8915
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.1633 0.1633
Echinococcus multilocularis purine nucleoside phosphorylase 0.0453 0.7865 0.7865
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1646 0.1605
Echinococcus granulosus tumor protein p63 0.033 0.5643 0.5643
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0548 0.0548
Schistosoma mansoni uridine phosphorylase 0.0118 0.1826 0.1826
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0565 0.0519
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0079 0.0173
Trypanosoma brucei uridine phosphorylase 0.0118 0.1826 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0048 0.0048
Brugia malayi MH2 domain containing protein 0.0033 0.0292 0.0269
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0118 0.1826 1
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0992 0.0949
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0992 0.0992
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0118 0.1826 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0992 0.0949
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0571 1 1
Schistosoma mansoni survival motor neuron protein 0.0097 0.1441 0.1441
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0079 0.0173
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0966 0.0966
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0992 0.0453
Echinococcus multilocularis Smad4 0.0033 0.0292 0.0292
Onchocerca volvulus 0.0072 0.0992 0.0456
Onchocerca volvulus 0.0072 0.0992 0.0456
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0571 1 1
Schistosoma mansoni hypothetical protein 0.0023 0.0098 0.0098
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0119 0.0071
Loa Loa (eye worm) hypothetical protein 0.0071 0.0973 0.1143
Loa Loa (eye worm) hypothetical protein 0.0072 0.0992 0.1166
Loa Loa (eye worm) hypothetical protein 0.006 0.0781 0.0918
Schistosoma mansoni methylthioadenosine phosphorylase 0.0118 0.1826 0.1826
Loa Loa (eye worm) hypothetical protein 0.0048 0.0565 0.0664
Echinococcus granulosus purine nucleoside phosphorylase 0.0571 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0599 0.3101
Schistosoma mansoni hypothetical protein 0.0123 0.1908 0.1908
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0565 0.0543
Loa Loa (eye worm) transcription factor SMAD2 0.0489 0.8512 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0992 0.0992
Leishmania major methylthioadenosine phosphorylase, putative 0.0118 0.1826 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0773 0.0773
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0992 0.0949
Echinococcus granulosus purine nucleoside phosphorylase 0.0571 1 1
Brugia malayi hypothetical protein 0.0475 0.8273 0.8269
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0404
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0992 0.0949
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0992 0.5312
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0118 0.1826 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0118 0.1826 1
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0118 0.1826 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0079 0.0173
Schistosoma mansoni smad1 5 8 and 0.0033 0.0292 0.0292

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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