Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | trypanothione reductase | 0.0047 | 0.1173 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2543 | 0.2543 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.7365 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.1173 | 0.4614 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.6339 | 0.8342 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2543 | 0.2543 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1323 | 0.5203 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2543 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2543 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.1173 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.7365 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.6339 | 0.8342 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.7365 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.1173 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.6339 | 0.8342 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.6339 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.6339 | 0.8342 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.1173 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2543 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.6339 | 0.8342 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2543 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.1173 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1323 | 0.5203 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2543 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.1173 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.1173 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1323 | 0.5203 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.1173 | 0.4614 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2543 | 0.2543 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.1173 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.7365 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2543 | 0.2543 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1323 | 0.5203 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2543 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.1173 | 0.4614 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2543 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2543 | 0.2543 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2543 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.1173 | 0.4614 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.