Detailed information for compound 626049

Basic information

Technical information
  • TDR Targets ID: 626049
  • Name: 2-furan-2-yl-9-(4-methylphenyl)-8-oxo-7H-puri ne-6-carboxamide
  • MW: 335.317 | Formula: C17H13N5O3
  • H donors: 2 H acceptors: 5 LogP: 2.03 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)n1c(O)nc2c1nc(nc2C(=O)N)c1ccco1
  • InChi: 1S/C17H13N5O3/c1-9-4-6-10(7-5-9)22-16-13(20-17(22)24)12(14(18)23)19-15(21-16)11-3-2-8-25-11/h2-8H,1H3,(H2,18,23)(H,20,24)
  • InChiKey: MCTYJFSCTFGNBS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-furyl)-9-(4-methylphenyl)-8-oxo-7H-purine-6-carboxamide
  • 2-(2-furyl)-8-keto-9-(4-methylphenyl)-7H-purine-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0461 0.11
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0635 0.1554
Echinococcus granulosus GPCR family 2 0.0031 0.0338 0.078
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0221 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0461 0.119
Schistosoma mansoni tar DNA-binding protein 0.0133 0.2586 0.6677
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0461 0.0386
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0461 0.11
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0461 0.0386
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0338 0.078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0635 0.1554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0635 0.1639
Schistosoma mansoni zinc finger protein 0.002 0.0095 0.0246
Schistosoma mansoni ap endonuclease 0.0019 0.0078 0.0202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1014 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0221 0.0194
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0078 0.0029
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0461 0.0386
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1014 0.2617
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0078 0.0065
Echinococcus granulosus histone lysine methyltransferase setb 0.0076 0.1342 0.3399
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0461 0.4548
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1014 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0078 0.1698
Brugia malayi RNA binding protein 0.0133 0.2586 0.294
Schistosoma mansoni hypothetical protein 0.0031 0.0338 0.0873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0635 0.1554
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0078 0.0102
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1014 0.2542
Loa Loa (eye worm) hypothetical protein 0.0031 0.0338 0.0328
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1806 0.2045
Brugia malayi hypothetical protein 0.0025 0.0221 0.0229
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0221 1
Schistosoma mansoni hypothetical protein 0.0066 0.1127 0.2909
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0635 0.0703
Loa Loa (eye worm) hypothetical protein 0.0071 0.1237 0.1362
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.046 0.1099
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0078 0.5
Schistosoma mansoni inositol monophosphatase 0.0036 0.0461 0.119
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0076 0.1342 0.3399
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0338 0.0328
Schistosoma mansoni hypothetical protein 0.0191 0.3873 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0461 1
Schistosoma mansoni hypothetical protein 0.0021 0.0119 0.0307
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0377 0.3192
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0221 0.4796
Leishmania major hypothetical protein, conserved 0.0025 0.0221 0.2181
Schistosoma mansoni hypothetical protein 0.0031 0.0338 0.0873
Schistosoma mansoni bromodomain containing protein 0.0064 0.1071 0.2764
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0377 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1014 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.1342 0.3466
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0461 1
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.2586 0.294
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.8745 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0162 0.032
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0221 0.1616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0962 0.2484
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0078 0.1698
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0461 0.4091
Brugia malayi Bromodomain containing protein 0.0039 0.0513 0.0563
Plasmodium vivax SET domain protein, putative 0.0059 0.0962 1
Schistosoma mansoni ap endonuclease 0.0019 0.0078 0.0202
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1014 0.2542
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1806 0.2017
Trichomonas vaginalis set domain proteins, putative 0.0468 1 1
Echinococcus granulosus zinc finger protein 0.002 0.0095 0.0147
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0914 0.2282
Schistosoma mansoni hypothetical protein 0.0031 0.0338 0.0873
Echinococcus multilocularis geminin 0.0191 0.3873 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1127 0.1235
Loa Loa (eye worm) hypothetical protein 0.0043 0.061 0.0641
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0338 0.0363
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0039 0.0101
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0962 0.9448
Echinococcus granulosus tar DNA binding protein 0.0133 0.2586 0.6643
Brugia malayi PHD-finger family protein 0.0025 0.0214 0.0221
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0338 0.0363
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0119 0.0076
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0162 0.0417
Schistosoma mansoni tar DNA-binding protein 0.0133 0.2586 0.6677
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0991 0.2482
Echinococcus multilocularis GPCR, family 2 0.0031 0.0338 0.078
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1014 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0962 0.2407
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0078 0.1698
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0635 0.067
Brugia malayi Pre-SET motif family protein 0.0059 0.0962 0.1078
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0078 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.1342 0.3466
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1806 0.2045
Brugia malayi Pre-SET motif family protein 0.0411 0.8745 1
Echinococcus multilocularis zinc finger protein 0.002 0.0095 0.0147
Echinococcus multilocularis tar DNA binding protein 0.0133 0.2586 0.6643
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.2586 0.2915
Loa Loa (eye worm) RNA binding protein 0.0133 0.2586 0.2915
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0461 1
Brugia malayi TAR-binding protein 0.0133 0.2586 0.294
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.046 0.1099
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0221 0.1527
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0461 1
Loa Loa (eye worm) inositol-1 0.0036 0.0461 0.047
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0338 0.078
Loa Loa (eye worm) hypothetical protein 0.0097 0.1806 0.2017
Brugia malayi Inositol-1 0.0036 0.0461 0.0503
Schistosoma mansoni tar DNA-binding protein 0.0133 0.2586 0.6677
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0039 0.0101
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0221 0.4796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0635 0.1639
Schistosoma mansoni tar DNA-binding protein 0.0133 0.2586 0.6677
Loa Loa (eye worm) TAR-binding protein 0.0133 0.2586 0.2915
Brugia malayi Bromodomain containing protein 0.0076 0.1332 0.1502
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0078 0.0772
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0461 0.4091
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0221 0.4796
Schistosoma mansoni hypothetical protein 0.0031 0.0338 0.0873
Loa Loa (eye worm) hypothetical protein 0.0039 0.0515 0.0532
Loa Loa (eye worm) hypothetical protein 0.0041 0.0568 0.0592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0635 0.1554
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1014 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0078 0.0102
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0991 0.2482
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0338 0.078
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0162 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0635 0.1639
Schistosoma mansoni hypothetical protein 0.0191 0.3873 1
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.1127 0.1267
Echinococcus granulosus geminin 0.0191 0.3873 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1014 0.2617
Loa Loa (eye worm) hypothetical protein 0.0076 0.1342 0.1484
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0461 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0962 0.2484
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0338 0.078
Schistosoma mansoni tar DNA-binding protein 0.0133 0.2586 0.6677
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1014 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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