Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0065 | 0.0396 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.011 | 1 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.9604 | 0.9604 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0065 | 0.0396 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.011 | 1 | 1 |
Onchocerca volvulus | 0.011 | 1 | 0.5 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.011 | 1 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.011 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0065 | 0.0396 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0065 | 0.0396 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0065 | 0.0396 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.011 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KB (functional) | = 5.59 % | In vitro Histamine H2 receptor antagonist activity in the histamine-stimulated guinea pig right atrium | ChEMBL. | 2894467 |
-Log KB (functional) | = 5.59 % | In vitro Histamine H2 receptor antagonist activity in the histamine-stimulated guinea pig right atrium | ChEMBL. | 2894467 |
Activity (ADMET) | = -1.17 | Log (Cbrain/Cblood) in rats | ChEMBL. | 2894467 |
Inhibition (functional) | = 48 % | Maximum percent inhibition of acid output in pentagastrin-stimulated Heidenhain pouch dog following 1 mg/kg i.v. administration. | ChEMBL. | 2866245 |
Inhibition (functional) | = 80 % | Maximum percent inhibition of acid output in pentagastrin-stimulated Heidenhain pouch dog at dose (5 mg/kg) administered intravenously | ChEMBL. | 2866245 |
KB (functional) | = 0.00000319 | Dissociation constant of H2 receptor antagonist activity against guinea pig atrium | ChEMBL. | 2866245 |
KB (functional) | = 0.00000319 | Dissociation constant of H2 receptor antagonist activity against guinea pig atrium | ChEMBL. | 2866245 |
Log BB (ADMET) | = -1.17 | logBB, log(C brain/C blood) | ChEMBL. | 8941388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.