Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0952 | 0.2052 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3594 | 0.3315 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0952 | 0.0689 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2371 | 0.2039 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0418 | 0.014 |
Echinococcus granulosus | muscleblind protein | 0.016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3594 | 0.3315 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.4452 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.3948 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3594 | 0.3321 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.1956 | 0.1605 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2874 | 0.2667 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0234 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2371 | 0.2046 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2519 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0952 | 0.0557 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.1956 | 0.1613 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2519 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.2083 | 0.4619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0234 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0234 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2874 | 0.2667 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2519 | 0.2301 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.2874 | 0.257 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0952 | 0.0557 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.2083 | 0.4619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0234 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0952 | 0.0689 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3594 | 0.3321 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2519 | 0.5609 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2874 | 0.2667 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2519 | 0.5609 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.2874 | 0.2563 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0234 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2874 | 0.6417 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0952 | 0.2052 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0952 | 0.0566 |
Onchocerca volvulus | 0.0035 | 0.1956 | 0.5 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0418 | 0.014 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0952 | 0.0689 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0952 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0234 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2519 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0952 | 0.2052 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2371 | 0.5275 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.2083 | 0.1853 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2874 | 0.2667 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0234 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0952 | 0.0689 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0952 | 0.2052 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.1956 | 0.4331 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2519 | 0.2301 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2874 | 0.6417 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0952 | 0.0689 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0234 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2519 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2519 | 0.2199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0234 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2874 | 0.6417 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0952 | 0.0566 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0282 | 0.0531 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.2083 | 0.1853 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1689 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 2.2387 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.