Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0054 | 0.7838 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6052 | 0.6016 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.183 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.069 | 0.0352 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6052 | 0.5759 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6052 | 0.5759 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0054 | 0.7838 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.183 | 0.166 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.183 | 0.1533 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.8617 | 0.8617 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1167 | 0.1087 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.8617 | 0.8567 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.528 | 0.528 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.183 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6052 | 0.6016 |
Mycobacterium ulcerans | hypothetical protein | 0.0054 | 0.7838 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.2632 | 0.2632 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0026 | 0.2463 | 0.2395 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.7838 | 0.7838 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 1 | 1 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0016 | 0.069 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0041 | 0.528 | 0.6682 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2632 | 0.2632 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.7559 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.5169 | 0.5169 |
Brugia malayi | hypothetical protein | 0.0034 | 0.4071 | 0.3856 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6052 | 0.6016 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0054 | 0.7838 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.183 | 0.1595 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0054 | 0.7838 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0054 | 0.7838 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0054 | 0.7838 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0351 | 0.0351 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.069 | 0.0546 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0041 | 0.528 | 0.6617 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.8617 | 0.8617 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0016 | 0.069 | 0.0606 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.069 | 0.0352 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.2632 | 0.2565 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0016 | 0.069 | 0.0546 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0016 | 0.069 | 0.0546 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.7559 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.183 | 0.166 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.4867 | 0.6071 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.7559 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0016 | 0.069 | 0.069 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0054 | 0.7838 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.2132 | 0.2061 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.183 | 0.6431 |
Onchocerca volvulus | 0.002 | 0.1394 | 0.0984 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.5169 | 0.4811 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.2132 | 0.2061 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.2632 | 0.2565 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 1 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0026 | 0.2463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.069 | 0.069 |
Echinococcus multilocularis | musashi | 0.0026 | 0.2632 | 0.2565 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.069 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.528 | 0.528 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.5169 | 0.4993 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.4867 | 0.6071 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.2463 | 0.2581 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.2007 | 0.1415 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0041 | 0.528 | 0.6421 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0016 | 0.069 | 0.0352 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1167 | 0.0513 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0054 | 0.7838 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0054 | 0.7838 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.183 | 0.1756 |
Brugia malayi | AMP-binding enzyme family protein | 0.0054 | 0.7838 | 0.7759 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.183 | 0.183 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.069 | 0.0352 |
Brugia malayi | AMP-binding enzyme family protein | 0.0054 | 0.7838 | 0.7759 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1167 | 0.1087 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0054 | 0.7838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.528 | 0.528 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.069 | 0.069 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.069 | 0.0546 |
Plasmodium falciparum | flap endonuclease 1 | 0.0026 | 0.2463 | 0.2581 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.2632 | 0.2565 |
Echinococcus granulosus | lamin | 0.0026 | 0.2632 | 0.2565 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0041 | 0.528 | 0.6682 |
Entamoeba histolytica | Flap nuclease, putative | 0.0026 | 0.2463 | 0.2481 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.183 | 0.1756 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.2632 | 0.2364 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.528 | 0.528 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.7559 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 0.2632 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.009 | 0.009 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.4867 | 0.6071 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1167 | 0.1087 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0054 | 0.7838 | 1 |
Onchocerca volvulus | 0.0026 | 0.2632 | 0.2717 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.7559 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0026 | 0.2463 | 0.2189 |
Brugia malayi | hypothetical protein | 0.0053 | 0.7559 | 0.747 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0026 | 0.2463 | 0.2581 |
Onchocerca volvulus | 0.0054 | 0.7838 | 1 | |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0026 | 0.2463 | 0.2581 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.183 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.7559 | 0.7559 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0054 | 0.7838 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.6052 | 0.5909 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.6052 | 0.6052 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0026 | 0.2463 | 0.2463 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.183 | 0.1595 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0016 | 0.069 | 0.0546 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.1167 | 0.1087 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.183 | 0.166 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.8617 | 0.8567 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.1167 | 0.0846 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0054 | 0.7838 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1167 | 0.0513 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0054 | 0.7838 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.7559 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0016 | 0.069 | 0.069 |
Brugia malayi | AMP-binding enzyme family protein | 0.0054 | 0.7838 | 0.7759 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1167 | 0.1087 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.183 | 0.1225 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0016 | 0.069 | 0.0352 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0016 | 0.069 | 0.0546 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0016 | 0.069 | 0.0546 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0054 | 0.7838 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6052 | 0.5759 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0016 | 0.069 | 0.0606 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.069 | 0.0352 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.183 | 0.166 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.183 | 0.2054 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.183 | 0.166 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.1167 | 0.1167 |
Echinococcus multilocularis | lamin | 0.0026 | 0.2632 | 0.2565 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0054 | 0.7838 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0016 | 0.069 | 0.0546 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.2632 | 0.2086 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.1167 | 0.0846 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1167 | 0.0513 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6052 | 0.6016 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.7559 | 0.961 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.2632 | 0.2632 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.2632 | 0.2364 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.7838 | 0.7838 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0016 | 0.069 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.528 | 0.528 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.7838 | 0.7838 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0041 | 0.528 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.1167 | 0.1087 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0054 | 0.7838 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.7559 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.183 | 0.6431 |
Brugia malayi | TAR-binding protein | 0.0066 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.4867 | 0.6071 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.183 | 0.1225 |
Onchocerca volvulus | 0.0026 | 0.2632 | 0.2717 | |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1167 | 0.0513 |
Echinococcus granulosus | flap endonuclease 1 | 0.0026 | 0.2463 | 0.2395 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.069 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.2132 | 0.1549 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2542 | 0.2542 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0026 | 0.2463 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 0.2632 | 0.2086 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.183 | 0.166 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.2463 | 0.2481 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.2463 | 0.2581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.