Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0523 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0115 | 0.251 | 0.251 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0523 | 0.0877 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0397 | 0.0666 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0523 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0712 | 0.2259 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0523 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0523 | 0.2074 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0523 | 0.0877 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0523 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0042 | 0.0523 | 0.0362 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0523 | 0.0877 |
Entamoeba histolytica | hypothetical protein | 0.0115 | 0.251 | 1 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0397 | 0.0666 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0271 | 0.6751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0523 | 0.0877 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1003 | 0.1105 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0523 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0523 | 0.2074 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0042 | 0.0523 | 0.0362 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0042 | 0.0523 | 0.0362 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0397 | 0.126 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0397 | 0.126 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0523 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0712 | 0.1195 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0397 | 0.0397 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0139 | 0.3153 | 0.5288 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5962 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0042 | 0.0523 | 0.0362 |
Onchocerca volvulus | 0.0042 | 0.0523 | 0.7341 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1003 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.3199 | 0.5366 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0523 | 0.0877 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0523 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0523 | 0.2074 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1003 | 0.3181 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1003 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0523 | 0.0523 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 0.5962 | 0.5962 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0115 | 0.251 | 0.421 |
Onchocerca volvulus | 0.0042 | 0.0523 | 0.7341 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0523 | 0.0877 |
Entamoeba histolytica | hypothetical protein | 0.0115 | 0.251 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0712 | 0.2259 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1003 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0523 | 0.0362 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0523 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0523 | 0.2074 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0523 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0523 | 0.0877 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0523 | 0.2074 |
Entamoeba histolytica | hypothetical protein | 0.0115 | 0.251 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0115 | 0.251 | 0.7961 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0523 | 0.0877 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1003 | 0.1003 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0523 | 0.1658 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0523 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0042 | 0.0523 | 0.0362 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0139 | 0.3153 | 0.3153 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 0.5962 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0523 | 0.0362 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0042 | 0.0523 | 0.0362 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0523 | 0.0877 |
Onchocerca volvulus | 0.0042 | 0.0523 | 0.7341 | |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0523 | 0.0877 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1003 | 0.1682 |
Schistosoma mansoni | lipoxygenase | 0.0139 | 0.3153 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0097 | 0.2014 | 0.6387 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.3199 | 0.5366 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0523 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0523 | 0.0877 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1003 | 0.3181 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1003 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0523 | 0.0877 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0042 | 0.0523 | 0.0362 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0397 | 0.0666 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.3199 | 0.5366 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0397 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0523 | 0.2074 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0523 | 1 |
Brugia malayi | hypothetical protein | 0.0115 | 0.251 | 0.421 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0523 | 0.0877 |
Brugia malayi | hypothetical protein | 0.0242 | 0.5962 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.251 | 0.7961 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0523 | 0.2074 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0523 | 0.0362 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0523 | 0.1658 |
Onchocerca volvulus | 0.0049 | 0.0712 | 1 | |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0115 | 0.251 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.