Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0195 | 0.0222 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0195 | 0.0312 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.5102 | 0.8432 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0195 | 0.0222 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.5102 | 0.8187 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0285 | 0.0471 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.107 | 0.1768 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.107 | 0.1716 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0195 | 0.0222 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.876 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0904 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0153 | 0.6232 | 0.7114 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.5102 | 0.8187 |
Onchocerca volvulus | 0.0031 | 0.107 | 0.0892 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.5337 | 0.8564 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0195 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0904 | 0.1032 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.1679 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0195 | 0.0222 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.5102 | 0.8187 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0195 | 0.0222 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0195 | 0.0322 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.5102 | 0.5824 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0195 | 0.0222 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0195 | 0.0322 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.107 | 0.1221 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.107 | 0.1716 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.4924 | 0.7902 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.5102 | 0.8187 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.107 | 0.2143 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0149 | 0.6051 | 1 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0195 | 0.0222 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1755 | 0.2004 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0195 | 0.0312 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0153 | 0.6232 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.107 | 0.1716 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.5337 | 0.8564 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0195 | 0.0222 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0195 | 0.0222 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0285 | 0.0457 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.1521 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0195 | 0.0222 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0195 | 0.0312 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0195 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0195 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.107 | 0.1221 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.107 | 0.1716 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0904 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0195 | 0.0222 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0195 | 0.0222 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0195 | 0.0222 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1755 | 0.2901 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.1679 | 0.2774 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0195 | 0.0312 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0195 | 0.0312 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0506 | 0.0578 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0195 | 0.0222 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0195 | 0.0322 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0195 | 0.0222 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0195 | 0.0312 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0195 | 0.0312 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0195 | 0.0222 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1755 | 0.2816 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0195 | 0.0312 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0195 | 0.0222 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0195 | 0.0222 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0195 | 0.0222 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0153 | 0.6232 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0195 | 0.0222 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.107 | 0.1716 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.107 | 0.2143 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.5102 | 0.5824 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0195 | 0.0312 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0195 | 0.0222 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.5337 | 0.8564 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1755 | 0.2816 |
Brugia malayi | RNA binding protein | 0.0126 | 0.5102 | 0.5824 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.4924 | 0.7902 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0195 | 0.0222 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.876 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0195 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0195 | 0.0222 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.1022 | 0.1689 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0195 | 0.0222 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0195 | 0.0222 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.5102 | 0.8187 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.1521 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1755 | 0.2816 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0195 | 0.0312 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0195 | 0.0312 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0195 | 0.0312 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0195 | 0.0312 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0904 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0195 | 0.0222 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0904 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0195 | 0.0222 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0195 | 0.0312 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0195 | 0.0312 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1755 | 0.2816 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.5102 | 0.5824 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.1521 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.5102 | 0.8187 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1755 | 0.2816 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0153 | 0.6232 | 0.7114 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0195 | 0.0222 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0285 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0195 | 0.0222 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0904 | 0.1032 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0195 | 0.0322 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0195 | 0.0312 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1755 | 0.2004 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0195 | 0.0322 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0195 | 0.0222 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.4924 | 0.8138 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0195 | 0.0222 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0195 | 0.0312 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.5102 | 0.5824 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.1679 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0195 | 0.0322 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0195 | 0.0312 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0195 | 0.0322 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.107 | 0.1716 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0195 | 0.0222 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0195 | 0.0322 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.5102 | 0.5824 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0195 | 0.0222 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0195 | 0.0322 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.1679 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1755 | 0.2901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.