Detailed information for compound 626846

Basic information

Technical information
  • TDR Targets ID: 626846
  • Name: N-(4-bromo-2-methylphenyl)-1-[(2-fluorophenyl )methoxy]-2-oxopyridine-3-carboxamide
  • MW: 431.255 | Formula: C20H16BrFN2O3
  • H donors: 1 H acceptors: 2 LogP: 4.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(c(c1)C)NC(=O)c1cccn(c1=O)OCc1ccccc1F
  • InChi: 1S/C20H16BrFN2O3/c1-13-11-15(21)8-9-18(13)23-19(25)16-6-4-10-24(20(16)26)27-12-14-5-2-3-7-17(14)22/h2-11H,12H2,1H3,(H,23,25)
  • InChiKey: JNICUICYQPFSLO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromo-2-methyl-phenyl)-1-[(2-fluorophenyl)methoxy]-2-oxo-pyridine-3-carboxamide
  • N-(4-bromo-2-methylphenyl)-1-[(2-fluorophenyl)methoxy]-2-oxo-3-pyridinecarboxamide
  • N-(4-bromo-2-methyl-phenyl)-1-(2-fluorobenzyl)oxy-2-keto-nicotinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0121 0.5784
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0121 0.3793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0059 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0161 0.0161
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.1105 0.1981
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0198 1
Echinococcus multilocularis lamin dm0 0.0057 0.0252 0.0252
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.012 0.0141
Brugia malayi Pre-SET motif family protein 0.0441 0.3004 0.5528
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0014
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0088 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0059 0.0059
Brugia malayi Cytochrome P450 family protein 0.0056 0.0241 0.0367
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.012 0.053
Schistosoma mansoni microtubule-associated protein tau 0.1416 1 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0045 0.161
Brugia malayi jmjC domain containing protein 0.0035 0.0088 0.0081
Loa Loa (eye worm) hypothetical protein 0.0485 0.3321 0.6131
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0059 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0161 0.0161
Brugia malayi intermediate filament protein 0.0057 0.0252 0.0387
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0088 0.0088
Echinococcus granulosus jumonji domain containing protein 0.004 0.0125 0.0125
Onchocerca volvulus 0.0057 0.0252 0.061
Schistosoma mansoni alpha-glucosidase 0.0152 0.0929 0.0929
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.012 0.0013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0116 0.0633
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0059 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.1319 0.2381
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.012 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.012 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0065 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0053
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0465 0.0465
Brugia malayi ecdysteroid receptor 0.0031 0.0059 0.0027
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0252 0.0412
Onchocerca volvulus 0.0039 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0053
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0308 0.0308
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0059 0.0043
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0512 0.0512
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0308 0.0308
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0198 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0059 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0161 0.0161
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0198 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.1105 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0059 0.0027
Leishmania major hypothetical protein, conserved 0.0039 0.0116 0.1462
Echinococcus multilocularis musashi 0.0057 0.0252 0.0252
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0116 0.552
Schistosoma mansoni hypothetical protein 0.0141 0.0851 0.0851
Schistosoma mansoni alpha-glucosidase 0.0152 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0059 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0308 0.0491
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0293 0.4039
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0038 0.0038
Mycobacterium ulcerans hypothetical protein 0.0039 0.0116 0.1462
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0868 0.6069 0.6069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0161 0.0161
Loa Loa (eye worm) beta-lactamase 0.0039 0.0116 0.0159
Loa Loa (eye worm) hypothetical protein 0.0087 0.0465 0.0809
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0121 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0116 0.0116
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0121 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0059 0.0053
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0116 0.0633
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0159
Mycobacterium ulcerans lipase LipD 0.0039 0.0116 0.1462
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0059 0.0059
Onchocerca volvulus 0.0502 0.3441 1
Echinococcus granulosus peregrin 0.0029 0.0045 0.0045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0111 0.0634 0.0634
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0121 0.0121
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0121 0.5784
Echinococcus granulosus muscleblind protein 0.0774 0.5398 0.5398
Loa Loa (eye worm) hypothetical protein 0.0065 0.0308 0.0516
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0116 0.0133
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0123 0.5913
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0116 0.0633
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.1606 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0116 0.0633
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.1105 0.2002
Schistosoma mansoni hypothetical protein 0.0693 0.4816 0.4816
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.012 0.0013
Echinococcus granulosus GPCR family 2 0.0065 0.0308 0.0308
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0121 0.9782
Onchocerca volvulus 0.0039 0.0116 0.021
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0123 0.1566
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0059 0.0027
Schistosoma mansoni hypothetical protein 0.0029 0.0045 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0277 0.0277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0293 0.0293
Echinococcus multilocularis lamin 0.0057 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0059 0.0027
Mycobacterium ulcerans beta-lactamase 0.0039 0.0116 0.1462
Schistosoma mansoni coup transcription factor 0.0031 0.0059 0.0059
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0116 0.1462
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0045 0.0045
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0465 0.0785
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0159
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0308 0.0308
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0123 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0015 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0252 0.0412
Plasmodium vivax SET domain protein, putative 0.0063 0.0293 1
Brugia malayi Inositol-1 0.004 0.0123 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0121 0.0588
Onchocerca volvulus 0.0031 0.0059 0.0043
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0123 0.0022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0704 1
Brugia malayi hypothetical protein 0.0032 0.0071 0.0049
Loa Loa (eye worm) hypothetical protein 0.0141 0.0851 0.1528
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0116 0.0633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0059 0.0059
Brugia malayi Pre-SET motif family protein 0.0063 0.0293 0.0464
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0116 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0293 0.0293
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0059 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0116 0.3621
Brugia malayi Muscleblind-like protein 0.0774 0.5398 1
Brugia malayi steroid hormone receptor 0.0031 0.0059 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0308 0.0308
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0704 0.0704
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0465 0.0465
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0293 0.0293
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0059 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0059 0.0059
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0198 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.1105 0.1105
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0045 0.0026
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0111 0.0634 0.1102
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0059 0.0059
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0111 0.0634 0.0634
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0116 0.0116
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0121 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0059 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0704 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0244 0.0398
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0116 0.1462
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.1319 0.2401
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0059 0.0059
Brugia malayi beta-lactamase 0.0039 0.0116 0.0133
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0065 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0774 0.5398 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0159
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0065 0.0308 0.0308
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0123 0.1566
Trypanosoma brucei glucosidase, putative 0.0039 0.012 0.5758
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.012 0.0013
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0059 0.0059
Echinococcus multilocularis FTZ F1 alpha 0.0111 0.0634 0.0634
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0123 0.0876
Onchocerca volvulus 0.0102 0.0572 0.1551
Brugia malayi nuclear receptor NHR-88 0.0031 0.0059 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.3004 0.554
Echinococcus multilocularis muscleblind protein 0.0774 0.5398 0.5398
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0116 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0116 0.0159
Loa Loa (eye worm) hypothetical protein 0.0063 0.0293 0.0489
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0059 0.0027
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0093 0.7756
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0123 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0161 0.0218
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0121 0.0121
Schistosoma mansoni lamin 0.0057 0.0252 0.0252
Trichomonas vaginalis set domain proteins, putative 0.0502 0.3441 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0045 0.0427
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0059 0.0043
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0159
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0704 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0116 0.0633
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0059 0.0053
Brugia malayi hypothetical protein 0.005 0.0198 0.0286
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0851 0.1506
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.012 0.9738
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0198 0.2649
Loa Loa (eye worm) hypothetical protein 0.0111 0.0634 0.1125
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.012 0.9738
Schistosoma mansoni lamin 0.0057 0.0252 0.0252
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0059 0.0059
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0065 0.0308 0.0308
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0293 0.0293
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0059 0.0059
Echinococcus granulosus lamin 0.0057 0.0252 0.0252
Mycobacterium tuberculosis Conserved protein 0.0039 0.0116 0.0633
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0161 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0161 0.0161
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0093 0.0491
Brugia malayi jmjC domain containing protein 0.0094 0.0512 0.0873
Brugia malayi beta-lactamase family protein 0.0039 0.0116 0.0133
Mycobacterium tuberculosis Conserved protein 0.0039 0.0116 0.0633
Echinococcus multilocularis peregrin 0.0029 0.0045 0.0045
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0241 0.0392
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0123 0.1566
Mycobacterium leprae Probable lipase LipE 0.0039 0.0116 1
Onchocerca volvulus 0.0099 0.0549 0.1486
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0059 0.0027
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0123 0.0876
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0299
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.012 0.1525
Echinococcus multilocularis muscleblind protein 1 0.0774 0.5398 0.5398
Brugia malayi hypothetical protein 0.0485 0.3321 0.6121
Schistosoma mansoni hypothetical protein 0.0693 0.4816 0.4816
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0704 0.0704
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.012 0.053
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0116 0.0633
Schistosoma mansoni alpha glucosidase 0.0039 0.012 0.012
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.006 0.0029
Loa Loa (eye worm) hypothetical protein 0.0057 0.0252 0.0412
Schistosoma mansoni hypothetical protein 0.0099 0.0549 0.0549
Schistosoma mansoni hypothetical protein 0.008 0.0414 0.0414
Loa Loa (eye worm) inositol-1 0.004 0.0123 0.0172
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0088 0.0088
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0059 0.0053
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0704 0.0704
Echinococcus multilocularis survival motor neuron protein 1 0.0485 0.3321 0.3321
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0121 0.1532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0059 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0053
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0123 0.0123
Schistosoma mansoni ap endonuclease 0.0039 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0111 0.0634 0.1102
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0293 0.0293
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0206 0.1319 0.2401
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0121 0.0588
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0121 0.0663
Onchocerca volvulus 0.0057 0.0252 0.061
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0045 0.0427
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0159
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.012 0.0013
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.1105 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0059 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0059 0.0027
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.012 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0059 0.0027
Schistosoma mansoni intermediate filament proteins 0.0057 0.0252 0.0252
Onchocerca volvulus 0.0063 0.0293 0.0732
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0059 0.0059
Toxoplasma gondii ABC1 family protein 0.0039 0.0116 0.1462
Echinococcus granulosus intermediate filament protein 0.0057 0.0252 0.0252
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0045 0.0026
Brugia malayi beta-lactamase family protein 0.0039 0.0116 0.0133
Echinococcus granulosus lamin dm0 0.0057 0.0252 0.0252
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0123 1
Schistosoma mansoni survival motor neuron protein 0.0099 0.0549 0.0549
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0116 0.0633
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0111 0.0634 0.0634
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0059 0.0059
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0308 0.0491
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0198 0.6559
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0059 0.0059
Brugia malayi nuclear hormone receptor 0.0031 0.0059 0.0027
Echinococcus multilocularis geminin 0.0693 0.4816 0.4816
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0704 0.0704
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0465 0.0465
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0704 0.4326
Onchocerca volvulus 0.0039 0.0116 0.021
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0263 0.0433
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0308 0.0516
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0121 0.9782
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0088 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0059 0.0053
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.012 0.012
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0059 0.0059
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0123 0.0022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0159
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.006 0.0055
Schistosoma mansoni inositol monophosphatase 0.004 0.0123 0.0123
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0125 0.0125
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0038 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0774 0.5398 1
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0059 0.0027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0121 0.1532
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0059 0.0027
Schistosoma mansoni inositol monophosphatase 0.004 0.0123 0.0123
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0121 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0059 0.0027
Toxoplasma gondii exonuclease III APE 0.0039 0.0121 0.1532
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.1319 0.2381
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0121 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0374 0.0374
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0045 0.1056
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0704 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0059 0.0059
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0059 0.0059
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0252 0.0387
Echinococcus granulosus FTZ F1 alpha 0.0408 0.2767 0.2767
Leishmania major hypothetical protein, conserved 0.005 0.0198 0.2649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0059 0.0053
Echinococcus granulosus geminin 0.0693 0.4816 0.4816
Schistosoma mansoni ap endonuclease 0.0039 0.0121 0.0121
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0161 0.0243
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0549 0.0943
Echinococcus multilocularis microtubule associated protein 2 0.1416 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.012 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0116 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0293 0.0293
Echinococcus granulosus survival motor neuron protein 1 0.0485 0.3321 0.3321
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.012 0.012
Echinococcus multilocularis GPCR, family 2 0.0065 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0053
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0121 0.0014
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0123 0.0123
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.012 0.1525
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0704 1
Onchocerca volvulus 0.0087 0.0465 0.1237

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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