Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate kinase | 0.0026 | 0.2273 | 0.2273 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0026 | 0.2273 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2273 | 0.1546 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0026 | 0.2273 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0028 | 0.2664 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0026 | 0.2273 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.2664 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.2664 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.2664 | 0.2664 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0026 | 0.2273 | 0.1546 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0028 | 0.2664 | 0.2664 |
Leishmania major | pyruvate kinase | 0.0026 | 0.2273 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0026 | 0.2273 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.2664 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0026 | 0.2273 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.0026 | 0.2273 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.2273 | 0.8533 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0028 | 0.2664 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0026 | 0.2273 | 0.8533 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0026 | 0.2273 | 0.5 |
Schistosoma mansoni | eyes absent homolog | 0.0069 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0026 | 0.2273 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0026 | 0.2273 | 0.1546 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0026 | 0.2273 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.0026 | 0.2273 | 0.5 |
Leishmania major | pyruvate kinase | 0.0026 | 0.2273 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0026 | 0.2273 | 0.1546 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0026 | 0.2273 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0026 | 0.2273 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0026 | 0.2273 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.2273 | 0.8533 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0026 | 0.2273 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0026 | 0.2273 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0026 | 0.2273 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0026 | 0.2273 | 0.2273 |
Brugia malayi | hypothetical protein | 0.0028 | 0.2664 | 0.0506 |
Echinococcus multilocularis | pyruvate kinase | 0.002 | 0.1289 | 0.484 |
Echinococcus granulosus | pyruvate kinase | 0.0026 | 0.2273 | 0.8533 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0026 | 0.2273 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.2664 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.