Detailed information for compound 627051

Basic information

Technical information
  • TDR Targets ID: 627051
  • Name: 6-ethyl-2-(3-phenylsulfonylpropanoylamino)-5, 7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxam ide
  • MW: 421.534 | Formula: C19H23N3O4S2
  • H donors: 2 H acceptors: 4 LogP: 1.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCc2c(C1)sc(c2C(=O)N)NC(=O)CCS(=O)(=O)c1ccccc1
  • InChi: 1S/C19H23N3O4S2/c1-2-22-10-8-14-15(12-22)27-19(17(14)18(20)24)21-16(23)9-11-28(25,26)13-6-4-3-5-7-13/h3-7H,2,8-12H2,1H3,(H2,20,24)(H,21,23)
  • InChiKey: YYYCTWPKBFPCNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-ethyl-2-[(1-oxo-3-phenylsulfonylpropyl)amino]-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0317 0.0374
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.002 0.0037
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0122 0.4134
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0135 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0317 0.0693
Schistosoma mansoni hypothetical protein 0.002 0.0068 0.008
Onchocerca volvulus 0.0027 0.0153 0.0547
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0317 0.0693
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0277 0.051
Echinococcus multilocularis lamin 0.0027 0.0153 0.0153
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0317 0.0567
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0317 0.0693
Echinococcus granulosus lysine specific demethylase 5A 0.0094 0.0991 0.1168
Onchocerca volvulus 0.003 0.0198 0.0709
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1048 0.1872
Onchocerca volvulus 0.0049 0.0437 0.1564
Onchocerca volvulus 0.0024 0.0122 0.0436
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0317 0.0924
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0453 0.544 0.6412
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1575 0.1575
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0122 0.0238
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0122 0.0238
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0135 0.0135
Brugia malayi jmjC domain containing protein 0.0025 0.0135 0.0241
Loa Loa (eye worm) hypothetical protein 0.0082 0.0837 0.1539
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1575 0.1575
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0248
Loa Loa (eye worm) CYP4Cod1 0.0016 0.002 0.0037
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0000033955 0.0000060622
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0317 0.0693
Loa Loa (eye worm) hypothetical protein 0.0065 0.0629 0.1156
Trypanosoma brucei glucosidase, putative 0.0037 0.0277 0.06
Echinococcus granulosus peregrin 0.0029 0.0178 0.021
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0122 0.0238
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0224
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0198 0.0234
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0122 0.0122
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.0122 0.0144
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0153 0.0281
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.8124
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.027 0.0318
Brugia malayi hypothetical protein 0.002 0.0068 0.0122
Echinococcus granulosus dna polymerase kappa 0.004 0.0317 0.0374
Echinococcus granulosus leukotriene A 4 hydrolase 0.0453 0.544 0.6412
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0065 0.0116
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0122 0.0224
Schistosoma mansoni lamin 0.0027 0.0153 0.018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.027 0.0318
Trypanosoma cruzi Aminopeptidase M1, putative 0.0024 0.0122 0.0238
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0122 0.0122
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0135 0.0248
Brugia malayi Doublecortin family protein 0.002 0.0068 0.0122
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2435 0.4477
Schistosoma mansoni DNA helicase recq1 0.0019 0.0065 0.0076
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0135 0.0268
Echinococcus granulosus RUN 0.002 0.0068 0.008
Onchocerca volvulus 0.0024 0.0122 0.0436
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0024 0.0122 0.0144
Schistosoma mansoni jun-related protein 0.0068 0.067 0.079
Onchocerca volvulus 0.002 0.0068 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1575 0.1857
Loa Loa (eye worm) hypothetical protein 0.0361 0.4307 0.7916
Plasmodium falciparum phd finger protein, putative 0.0029 0.0178 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0277 0.0778
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0317 0.0317
Trichomonas vaginalis set domain proteins, putative 0.024 0.2796 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0122 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Schistosoma mansoni DNA polymerase eta 0.004 0.0317 0.0374
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0153 0.0273
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.0991 0.1168
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.8484 0.8484
Echinococcus multilocularis lamin dm0 0.0027 0.0153 0.0153
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0000033955 0.0000062416
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0119
Loa Loa (eye worm) hypothetical protein 0.0049 0.0437 0.0804
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0122 0.0122
Echinococcus granulosus tumor protein p63 0.0338 0.4016 0.4734
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0135 0.0268
Onchocerca volvulus Alhambra homolog 0.0029 0.0178 0.0638
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0277 0.06
Brugia malayi intermediate filament protein 0.0027 0.0153 0.0273
Schistosoma mansoni jumonji domain containing protein 0.0134 0.1485 0.1751
Echinococcus multilocularis jun protein 0.0084 0.0866 0.0866
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.0122 0.0224
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0122 0.0144
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0211 0.0388
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1575 0.1857
Brugia malayi Pre-SET motif family protein 0.003 0.0198 0.0354
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0248
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0068 0.0068
Schistosoma mansoni alpha-glucosidase 0.0142 0.1583 0.1866
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0135 0.0248
Brugia malayi Cytochrome P450 family protein 0.0016 0.002 0.0036
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0065 0.0116
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0224
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0317 0.0374
Loa Loa (eye worm) hypothetical protein 0.004 0.0317 0.0583
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Schistosoma mansoni lipoxygenase 0.0118 0.1287 0.1517
Brugia malayi jmjC domain containing protein 0.0025 0.0135 0.0241
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0068 0.0068
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0065 0.0119
Brugia malayi hypothetical protein 0.0024 0.0122 0.0218
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0122 0.0218
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0317 0.0567
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0135 0.0268
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0661 0.118
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0122 0.0122
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0317 0.5
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0068 0.008
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.0991 0.0991
Trypanosoma brucei unspecified product 0.0027 0.0164 0.0336
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0277 0.0778
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0277 0.0778
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0135 0.0159
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0317 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0277 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0178 0.8486
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0065 0.0104
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0135 0.0135
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0122 0.2688
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0277 0.8412
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0277 0.06
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0122 0.0238
Brugia malayi jmjC domain containing protein 0.0094 0.0991 0.177
Echinococcus granulosus lamin 0.0027 0.0153 0.018
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0122 0.5024
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0065 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0164 0.0336
Echinococcus multilocularis conserved hypothetical protein 0.0677 0.8225 0.8225
Echinococcus granulosus geminin 0.0338 0.4013 0.473
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0211 0.0249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1575 0.1857
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0361 0.4307 1
Echinococcus multilocularis peregrin 0.0029 0.0178 0.0178
Schistosoma mansoni hypothetical protein 0.0068 0.067 0.079
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.8124
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0122 0.0209
Plasmodium vivax JmjC domain containing protein 0.0025 0.0135 0.5135
Leishmania major DNA polymerase eta, putative 0.004 0.0317 0.0693
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0991 0.1822
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.002 0.0037
Schistosoma mansoni hypothetical protein 0.0338 0.4013 0.473
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0122 0.0238
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0211 0.0377
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0122 0.0238
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1575 0.2812
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0281
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1048 0.1927
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0135 0.0159
Echinococcus granulosus dna polymerase eta 0.004 0.0317 0.0374
Schistosoma mansoni DNA helicase recq5 0.0019 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0224
Echinococcus granulosus bloom syndrome protein 0.0019 0.0065 0.0076
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.8124
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0065 0.0065
Leishmania major hypothetical protein, conserved 0.0025 0.0135 0.0268
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0317 0.0583
Echinococcus multilocularis RUN 0.002 0.0068 0.0068
Brugia malayi Pre-SET motif family protein 0.021 0.2435 0.4348
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0184 0.0217
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1868 0.2202
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0178 0.0328
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0178 0.021
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0065 0.0065
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0122 0.0238
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0122 0.2688
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.0249
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0065 0.0104
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0135 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0198 0.0234
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0068 0.0296
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0866 0.0866
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0122 0.0144
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0211 0.0377
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0122 0.0144
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0556 0.1023
Schistosoma mansoni alpha glucosidase 0.0037 0.0277 0.0327
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0198 0.6277
Brugia malayi Bromodomain containing protein 0.0029 0.0178 0.0319
Brugia malayi jmjC domain containing protein 0.0025 0.0135 0.0241
Loa Loa (eye worm) doublecortin family protein 0.002 0.0068 0.0125
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0317 1
Trypanosoma brucei unspecified product 0.004 0.0317 0.0693
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.8124
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0153 0.1724 0.2032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.027
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0122 0.5024
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0317 0.0374
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0277 0.06
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1575 0.1857
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0135 0.33
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0135 0.0135
Brugia malayi TATA binding protein associated factor 0.0024 0.0122 0.0218
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0317 0.5
Onchocerca volvulus 0.0027 0.0153 0.0547
Echinococcus granulosus hypothetical protein 0.0691 0.8402 0.9903
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1575 0.2895
Brugia malayi bZIP transcription factor family protein 0.0084 0.0866 0.1545
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0317 0.0693
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0122 0.0238
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0122 0.3426
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0317 0.0693
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0122 0.3426
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.1287 0.1287
Schistosoma mansoni polycystin 1-related 0.002 0.0068 0.008
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0122 0.4134
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1868 0.1868
Onchocerca volvulus 0.002 0.0068 0.0244
Brugia malayi Cytochrome P450 family protein 0.0016 0.002 0.0036
Trypanosoma brucei unspecified product 0.0027 0.0164 0.0336
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0065 0.0000000051737
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0122 0.0238
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0317 0.0693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1575 0.1857
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0065 0.0065
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0153 0.0281
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1048 0.1872
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0122 0.0238
Brugia malayi hypothetical protein 0.0208 0.2406 0.4295
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0065 0.0076
Echinococcus multilocularis GPCR, family 2 0.0031 0.0211 0.0211
Loa Loa (eye worm) RecQ helicase 0.0019 0.0065 0.0119
Onchocerca volvulus 0.0066 0.0642 0.2295
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0453 0.544 0.544
Schistosoma mansoni hypothetical protein 0.0029 0.0178 0.021
Echinococcus multilocularis musashi 0.0027 0.0153 0.0153
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.0991 0.1168
Schistosoma mansoni hypothetical protein 0.0036 0.027 0.0318
Schistosoma mansoni rab6-interacting 0.002 0.0068 0.008
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0135 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0211 0.0211
Onchocerca volvulus 0.0024 0.0122 0.0436
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.1287 0.1517
Brugia malayi hypothetical protein 0.0036 0.027 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0164 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0125
Schistosoma mansoni hypothetical protein 0.0338 0.4013 0.473
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0453 0.544 1
Onchocerca volvulus 0.0095 0.1006 0.3598
Echinococcus multilocularis aminopeptidase N 0.0024 0.0122 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0122 0.0144
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.0249
Echinococcus granulosus lamin dm0 0.0027 0.0153 0.018
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0277 0.8412
Echinococcus multilocularis dna polymerase kappa 0.004 0.0317 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0198 0.0234
Trypanosoma brucei C-8 sterol isomerase, putative 0.0361 0.4307 1
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0135 0.0159
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0277 0.0495
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0122 0.0144
Schistosoma mansoni loxhd1 0.002 0.0068 0.008
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0135 0.6168
Schistosoma mansoni intermediate filament proteins 0.0027 0.0153 0.018
Echinococcus multilocularis geminin 0.0338 0.4013 0.4013
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0178 0.0178
Brugia malayi hypothetical protein 0.0024 0.0122 0.0218
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1868 0.3434
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0277 0.0778
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0068 0.0068
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0135 0.33
Echinococcus multilocularis tumor protein p63 0.0338 0.4016 0.4016
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0068 0.008
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0135 0.0159
Echinococcus granulosus intermediate filament protein 0.0027 0.0153 0.018
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0317 0.0317
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.8484 1
Echinococcus granulosus phd:f box containing protein 0.0025 0.0135 0.0159
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0122 0.0209
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0135 0.0159
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0277 0.0778
Entamoeba histolytica aminopeptidase, putative 0.0024 0.0122 0.2261
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0277 0.0778
Echinococcus granulosus aminopeptidase N 0.0024 0.0122 0.0144
Leishmania major DNA polymerase kappa, putative 0.004 0.0317 0.0693
Brugia malayi PHD-finger family protein 0.0029 0.0178 0.0319
Brugia malayi jmjC domain containing protein 0.0153 0.1724 0.3078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0198 0.0198
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0317 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0122 0.0238
Loa Loa (eye worm) hypothetical protein 0.0185 0.2115 0.3888
Loa Loa (eye worm) hypothetical protein 0.0029 0.0178 0.0328
Loa Loa (eye worm) hypothetical protein 0.003 0.0198 0.0364
Brugia malayi jmjC domain containing protein 0.0025 0.0135 0.0241
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0122 0.2688
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0122 0.0238
Schistosoma mansoni hypothetical protein 0.0067 0.0661 0.0779
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0122 0.0218
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0866 0.102
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0277 0.0277
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.0249
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0122 0.0144
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0135 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0317 0.0693
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0277 0.0778
Giardia lamblia DINP protein human, muc B family 0.004 0.0317 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0065 0.0104
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1868 0.1868
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0122 0.0209
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0024 0.0122 0.0122
Echinococcus granulosus jun protein 0.0084 0.0866 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0122 0.0122
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0277 0.0327
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0122 0.0238
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0065 0.0076
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0068 0.008
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0437 0.0515
Echinococcus multilocularis dna polymerase eta 0.004 0.0317 0.0317
Schistosoma mansoni lamin 0.0027 0.0153 0.018
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0135 0.0135
Schistosoma mansoni alpha-glucosidase 0.0142 0.1583 0.1866
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0317 0.0924
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0153 0.1724 0.1724
Brugia malayi hypothetical protein 0.002 0.0068 0.0122
Echinococcus granulosus microtubule associated protein 2 0.0698 0.8484 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0277 0.0778
Plasmodium vivax SET domain protein, putative 0.003 0.0198 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0198 0.0198
Schistosoma mansoni lipoxygenase 0.0082 0.0847 0.0998
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.0249
Echinococcus granulosus jumonji domain containing protein 0.004 0.0317 0.0374
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0198 0.0234
Loa Loa (eye worm) hypothetical protein 0.0031 0.0211 0.0388
Loa Loa (eye worm) aminopeptidase N 0.0024 0.0122 0.0224
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0198 0.0234
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0178 0.5351
Loa Loa (eye worm) hypothetical protein 0.0099 0.1048 0.1927
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0164 0.0336
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0135 0.0135
Brugia malayi Serotonin receptor 0.0466 0.5601 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0661 0.1215
Giardia lamblia PHD finger protein 15 0.0029 0.0178 0.4501
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0277 0.0778
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0178 0.021
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0122 0.0218
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0122 0.0144
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0361 0.4307 0.7689
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1868 0.3335
Leishmania major C-8 sterol isomerase-like protein 0.0361 0.4307 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0211 0.0211
Brugia malayi hypothetical protein 0.0066 0.0642 0.1146
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0178 0.5351
Onchocerca volvulus 0.024 0.2796 1
Echinococcus granulosus GPCR family 2 0.0031 0.0211 0.0249
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0135 0.0248
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.027 0.027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0211 0.0249
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0122 0.0238
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0122 0.0238
Schistosoma mansoni rab6-interacting 0.002 0.0068 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0317 0.0693
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0317 0.0693
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0317 0.0693

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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