TDR Targets

Basic information

Technical information

TDR Targets ID: 627232
Name: N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl ]methanesulfonamide
MW: 305.375 | Formula: C13H11N3O2S2
H donors: 1 H acceptors: 4 LogP: 2.27 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)Nc1ccc(cc1)c1nc2c(s1)nccc2
InChi: 1S/C13H11N3O2S2/c1-20(17,18)16-10-6-4-9(5-7-10)12-15-11-3-2-8-14-13(11)19-12/h2-8,16H,1H3
InChiKey: BQOIXNCLWRPSIM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)methanesulfonamide
N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]methanesulfonamide
ChemDiv3_012191

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Loa Loa (eye worm)	carboxylesterase	0.0063	0.142	0.0969
Echinococcus granulosus	BC026374 protein S09 family	0.0063	0.142	0.1319
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.2904	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0063	0.142	0.4677
Brugia malayi	hypothetical protein	0.0082	0.1919	0.1919
Schistosoma mansoni	BC026374 protein (S09 family)	0.0063	0.142	0.1319
Brugia malayi	Carboxylesterase family protein	0.0376	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0082	0.1919	0.1493
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0117	0.5
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0063	0.142	0.1319
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0907	0.08
Echinococcus multilocularis	chromobox protein 1	0.0068	0.1552	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Onchocerca volvulus	Peroxidase homolog	0.0082	0.1919	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.042	0.2114
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.1552	1
Echinococcus granulosus	neuroligin	0.0063	0.142	0.1319
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0063	0.142	0.4677
Brugia malayi	Heterochromatin protein 1	0.0068	0.1552	0.1552
Brugia malayi	chromobox protein homolog 3	0.0038	0.0727	0.0727
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0949	0.0472
Echinococcus granulosus	chromobox protein 1	0.0068	0.1552	0.1451
Onchocerca volvulus		0.0082	0.1919	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0117	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.258	0.8837
Mycobacterium tuberculosis	Probable reductase	0.0106	0.258	0.8837
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.008	0.1886	0.179
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Trypanosoma brucei	trypanothione reductase	0.0046	0.0949	1
Treponema pallidum	NADH oxidase	0.0016	0.0117	0.5
Brugia malayi	Peroxidasin	0.0082	0.1919	0.1919
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Mycobacterium ulcerans	carboxylesterase, LipT	0.0063	0.142	1
Echinococcus multilocularis	peroxidasin	0.0082	0.1919	0.1823
Onchocerca volvulus		0.0063	0.142	0.6487
Loa Loa (eye worm)	animal heme peroxidase	0.0082	0.1919	0.1493
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.1987	0.1892
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0084	0.1987	0.1892
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0727	0.4254
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0376	1	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0063	0.142	0.4677
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0727	0.1601
Onchocerca volvulus	Peroxidase homolog	0.0082	0.1919	1
Echinococcus multilocularis	neuroligin	0.0063	0.142	0.1319
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.258	0.8837
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0949	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0063	0.142	0.1319
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0907	0.08
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0907	0.0907
Brugia malayi	Carboxylesterase family protein	0.0063	0.142	0.142
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.258	0.8837
Onchocerca volvulus	Peroxidasin homolog	0.0082	0.1919	1
Echinococcus granulosus	acetylcholinesterase	0.0376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.142	0.0969
Onchocerca volvulus		0.0063	0.142	0.6487
Echinococcus granulosus	carboxylesterase 5A	0.0376	1	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0063	0.142	0.1319
Onchocerca volvulus	Chorion peroxidase homolog	0.0082	0.1919	1
Brugia malayi	Carboxylesterase family protein	0.0063	0.142	0.142
Leishmania major	trypanothione reductase	0.0046	0.0949	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0907	0.08
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0063	0.142	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0063	0.142	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0063	0.142	0.0969
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.258	0.8837
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0949	0.0842
Onchocerca volvulus		0.0082	0.1919	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0907	0.08
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0949	0.0842
Brugia malayi	Animal haem peroxidase family protein	0.0082	0.1919	0.1919
Loa Loa (eye worm)	carboxylesterase	0.0063	0.142	0.0969
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0063	0.142	0.1319
Schistosoma mansoni	peroxidasin	0.0082	0.1919	0.1823
Loa Loa (eye worm)	carboxylesterase	0.0376	1	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.2904	1
Loa Loa (eye worm)	animal heme peroxidase	0.0082	0.1919	0.1493
Onchocerca volvulus	Dual oxidase homolog	0.0082	0.1919	1
Brugia malayi	hypothetical protein	0.0063	0.142	0.142
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0084	0.1987	0.1987
Schistosoma mansoni	gliotactin	0.0063	0.142	0.1319
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0949	1
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.1987	0.1892
Onchocerca volvulus		0.0063	0.142	0.6487
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.1521	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.042	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0063	0.142	0.0969
Plasmodium falciparum	glutathione reductase	0.0046	0.0949	1
Brugia malayi	Animal haem peroxidase family protein	0.0082	0.1919	0.1919
Echinococcus granulosus	peroxidasin	0.0082	0.1919	0.1823
Brugia malayi	Carboxylesterase family protein	0.0063	0.142	0.142
Brugia malayi	glutathione reductase	0.0046	0.0949	0.0949
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.2904	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0907	0.0429
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0807	0.4811
Onchocerca volvulus		0.0063	0.142	0.6487
Brugia malayi	Blistered cuticle protein 3	0.0082	0.1919	0.1919
Echinococcus multilocularis	potassium voltage gated channel protein	0.0084	0.1987	0.1892
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0949	1
Echinococcus multilocularis	chromobox protein 1	0.0068	0.1552	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Schistosoma mansoni	chromobox protein	0.0068	0.1552	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0727	0.0239
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0117	0.0117
Echinococcus multilocularis	acetylcholinesterase	0.0376	1	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.1552	0.1107
Schistosoma mansoni	chromobox protein	0.0068	0.1552	0.1451
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0117	0.5
Echinococcus granulosus	acetylcholinesterase	0.0376	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0082	0.1919	0.1493
Brugia malayi	Animal haem peroxidase family protein	0.0082	0.1919	0.1919
Brugia malayi	Animal haem peroxidase family protein	0.0082	0.1919	0.1919
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Onchocerca volvulus	Peroxidasin homolog	0.0082	0.1919	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0807	0.2164
Schistosoma mansoni	peroxidasin	0.0082	0.1919	0.1823
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0727	0.4254
Loa Loa (eye worm)	acetylcholinesterase 1	0.0376	1	1
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0949	0.0472
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0063	0.142	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0807	0.4811
Onchocerca volvulus		0.0063	0.142	0.6487
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.2904	1
Onchocerca volvulus		0.0082	0.1919	1
Echinococcus granulosus	chromobox protein 1	0.0068	0.1552	0.1451
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0907	0.08
Echinococcus multilocularis	para nitrobenzyl esterase	0.0063	0.142	0.1319
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.258	0.8837
Brugia malayi	Carboxylesterase family protein	0.0063	0.142	0.142
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0063	0.142	0.9085
Echinococcus granulosus	potassium voltage gated channel protein	0.0084	0.1987	0.1892
Brugia malayi	Animal haem peroxidase family protein	0.0082	0.1919	0.1919
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0063	0.142	0.1319
Echinococcus multilocularis	carboxylesterase 5A	0.0376	1	1
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0949	1
Brugia malayi	Thioredoxin reductase	0.0046	0.0949	0.0949
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.1552	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1987	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Schistosoma mansoni	acetylcholinesterase	0.0063	0.142	0.1319
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0117	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0907	0.08
Echinococcus multilocularis	acetylcholinesterase	0.0376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.142	0.0969
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0949	0.2985
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Loa Loa (eye worm)	blistered cuticle protein 3	0.0082	0.1919	0.1493
Trichomonas vaginalis	spcc417.12 protein, putative	0.0063	0.142	0.9085
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.142	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1919	0.1493
Loa Loa (eye worm)	hypothetical protein	0.0063	0.142	0.0969
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0907	0.08

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 627232