Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0468 | 0.0944 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0468 | 1 |
Onchocerca volvulus | 0.004 | 0.0468 | 0.0348 | |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0063 | 0.0941 | 0.174 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0468 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0468 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0468 | 0.0535 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.3311 | 0.2983 |
Onchocerca volvulus | 0.004 | 0.0468 | 0.0348 | |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0063 | 0.0941 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0468 | 0.0303 |
Brugia malayi | beta-lactamase | 0.004 | 0.0468 | 0.0399 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0124 | 0.2643 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0468 | 0.0944 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.3123 | 0.2786 |
Brugia malayi | Pre-SET motif family protein | 0.0063 | 0.0941 | 0.0948 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.4952 | 0.4704 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.4957 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.3123 | 0.2786 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.4952 | 0.4704 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0124 | 0.2643 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0468 | 0.0399 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0707 | 0.0677 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0124 | 0.2643 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0468 | 0.0944 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0586 | 0.0663 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0468 | 0.0535 |
Plasmodium vivax | SET domain protein, putative | 0.0063 | 0.0941 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0124 | 0.0141 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.3123 | 0.2786 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0124 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0195 | 0.3662 | 0.4189 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0368 | 0.0421 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0124 | 0.0141 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0468 | 0.5 |
Onchocerca volvulus | 0.004 | 0.0468 | 0.0348 | |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0124 | 0.2643 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0468 | 0.0535 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0061 | 0.0893 | 0.1331 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0063 | 0.0941 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0124 | 0.0141 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0124 | 0.2643 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.3123 | 0.2786 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0468 | 0.4971 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0468 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0368 | 0.0283 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0124 | 0.2643 |
Trichomonas vaginalis | set domain proteins, putative | 0.0501 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0586 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0941 | 0.1076 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0195 | 0.3662 | 0.4106 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0586 | 0.0371 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0586 | 0.0663 |
Echinococcus multilocularis | tar DNA binding protein | 0.0195 | 0.3662 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0195 | 0.3662 | 0.4189 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.4952 | 0.4704 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0169 | 0.3123 | 0.3037 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0468 | 0.0535 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.4952 | 0.4704 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0195 | 0.3662 | 0.4189 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0124 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0586 | 0.0371 |
Brugia malayi | Pre-SET motif family protein | 0.0441 | 0.8742 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3662 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0586 | 0.0371 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0707 | 0.0809 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0257 | 0.4952 | 0.5602 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0707 | 0.0677 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0468 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0468 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0468 | 0.0944 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0124 | 0.2643 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0468 | 0.0535 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0468 | 0.0944 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0468 | 0.0535 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0.0941 | 0.174 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3662 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0468 | 0.0303 |
Brugia malayi | TAR-binding protein | 0.0195 | 0.3662 | 0.4106 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.3123 | 0.2786 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0468 | 0.0944 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0468 | 0.0944 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0124 | 0.2643 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.3123 | 0.2786 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0257 | 0.4952 | 0.5664 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0.0941 | 0.174 |
Echinococcus granulosus | tar DNA binding protein | 0.0195 | 0.3662 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.4952 | 0.4704 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0063 | 0.0941 | 0.1481 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3662 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0468 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.3311 | 0.2983 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0468 | 0.0399 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0468 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0468 | 0.0944 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0586 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0707 | 0.0809 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0124 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.0941 | 0.0828 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.3123 | 0.2786 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0124 | 0.0249 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0063 | 0.0941 | 0.1481 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0468 | 0.0399 |
Brugia malayi | RNA binding protein | 0.0195 | 0.3662 | 0.4106 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3662 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3662 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0586 | 0.0537 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0468 | 0.0535 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0124 | 0.0249 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0468 | 0.0944 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0586 | 0.0671 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0.0941 | 0.174 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.4952 | 0.4704 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0441 | 0.8742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0468 | 0.0535 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0468 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0468 | 0.0944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.