Detailed information for compound 627598

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 382.453 | Formula: C21H20NO4S
  • H donors: 0 H acceptors: 1 LogP: 3.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc2c1[C](=NC(=O)c1cc(OC)cc(c1)OC)(S2)CC#C
  • InChi: 1S/C21H20N2O4S/c1-5-10-23-19-17(27-6-2)8-7-9-18(19)28-21(23)22-20(24)14-11-15(25-3)13-16(12-14)26-4/h1,7-9,11-13H,6,10H2,2-4H3/b22-21-
  • InChiKey: QXKHSQCVFZRYNJ-DQRAZIAOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0034 0.0075
Echinococcus granulosus zinc finger protein 0.0026 0.0049 0.0106
Trichomonas vaginalis chromobox protein, putative 0.007 0.0216 0.2221
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0941 0.3538 1
Schistosoma mansoni cpg binding protein 0.0061 0.018 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0018 0.003
Echinococcus granulosus dna polymerase eta 0.0022 0.0034 0.0065
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0034 0.0075
Echinococcus granulosus Smad4 0.0018 0.0016 0.0014
Schistosoma mansoni hypothetical protein 0.0225 0.0808 0.2259
Toxoplasma gondii ABC1 family protein 0.008 0.0255 0.0671
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0225 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0055 0.0554
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.0842 0.235
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0018 0.002
Mycobacterium ulcerans beta-lactamase 0.008 0.0255 0.0672
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0034 0.0075
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0018 0.003
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0027 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0498 0.0488
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0149 0.039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0149 0.0138
Schistosoma mansoni smad1 5 8 and 0.0018 0.0016 0.0014
Echinococcus granulosus GPCR family 2 0.0104 0.0347 0.0951
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0017 0.0161
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0034 0.0045
Onchocerca volvulus 0.0266 0.0965 0.5432
Schistosoma mansoni dihydrofolate reductase 0.0941 0.3538 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0034 0.005
Schistosoma mansoni hypothetical protein 0.0104 0.0347 0.0951
Loa Loa (eye worm) dihydrofolate reductase 0.0941 0.3538 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0045 0.0452
Echinococcus multilocularis smad 0.0018 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0329 0.1205 0.338
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0255 0.0676
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.0455 0.1241
Echinococcus granulosus cpg binding protein 0.0066 0.0202 0.054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0005
Brugia malayi dihydrofolate reductase family protein 0.0941 0.3538 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0107 0.0273
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0404 0.1096
Echinococcus multilocularis thymidylate synthase 0.0464 0.1721 0.1711
Plasmodium falciparum glutathione reductase 0.0052 0.0149 0.037
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0329 0.1205 0.3407
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0404 0.1096
Trichomonas vaginalis chromobox protein, putative 0.0042 0.011 0.1124
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0402 0.1089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0005
Echinococcus granulosus dna polymerase kappa 0.0022 0.0034 0.0065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0498 0.1409
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0018 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0149 0.037
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0255 0.0672
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0034 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0225 0.0808 0.2284
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0016 0.0014
Loa Loa (eye worm) Smad1 0.0018 0.0016 0.0005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0034 0.0339
Schistosoma mansoni cpg binding protein 0.0066 0.0202 0.054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0104 0.0347 0.0336
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.0455 0.061
Brugia malayi thymidylate synthase 0.0464 0.1721 0.4864
Brugia malayi Bromodomain containing protein 0.009 0.0293 0.0827
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0016 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0255 0.0672
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0034 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.0455 0.1241
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0255 0.0682
Plasmodium falciparum thioredoxin reductase 0.0052 0.0149 0.037
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.0044 0.0118 0.0295
Brugia malayi beta-lactamase family protein 0.008 0.0255 0.072
Schistosoma mansoni DNA polymerase eta 0.0022 0.0034 0.0065
Loa Loa (eye worm) histone methyltransferase 0.002 0.0025 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0045 0.0452
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0018 0.0007
Schistosoma mansoni chromobox protein 0.007 0.0216 0.0579
Echinococcus multilocularis geminin 0.0179 0.0631 0.0621
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0034 0.0045
Loa Loa (eye worm) beta-lactamase 0.008 0.0255 0.0682
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0941 0.3538 1
Echinococcus multilocularis dihydrofolate reductase 0.0941 0.3538 0.353
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0024 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0016 0.0005
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0034 0.005
Loa Loa (eye worm) hypothetical protein 0.008 0.0255 0.0682
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0498 0.1374
Brugia malayi MH1 domain containing protein 0.0018 0.0016 0.0046
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0034 0.0065
Schistosoma mansoni smad1 5 8 and 0.0018 0.0016 0.0014
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0014 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0255 0.2628
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0034 0.5
Brugia malayi chromobox protein homolog 3 0.0039 0.0098 0.0278
Echinococcus multilocularis GPCR, family 2 0.0104 0.0347 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0157 0.0412
Loa Loa (eye worm) MH2 domain-containing protein 0.0258 0.0933 0.2608
Brugia malayi MH2 domain containing protein 0.0018 0.0016 0.0046
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0016 0.0005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0512 0.1901 0.5349
Brugia malayi CHD4 protein 0.0017 0.0014 0.0041
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0062 0.005
Plasmodium vivax SET domain protein, putative 0.0035 0.0082 0.018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0255 0.0676
Treponema pallidum NADH oxidase 0.0018 0.0018 0.5
Trypanosoma brucei unspecified product 0.0022 0.0034 0.0075
Echinococcus granulosus chromobox protein 1 0.007 0.0216 0.0579
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0018 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0045 0.0452
Brugia malayi Thioredoxin reductase 0.0052 0.0149 0.042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0498 0.0488
Loa Loa (eye worm) thymidylate synthase 0.0464 0.1721 0.4843
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0014 0.0009
Brugia malayi MH2 domain containing protein 0.0018 0.0016 0.0046
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.011 0.0263
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0216 0.0571
Brugia malayi Pre-SET motif family protein 0.0234 0.0842 0.2381
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0255 0.0672
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0018 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0066 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0021 0.0201
Schistosoma mansoni chromobox protein 0.007 0.0216 0.0579
Schistosoma mansoni hypothetical protein 0.0104 0.0347 0.0951
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0498 0.1382
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0034 0.0075
Loa Loa (eye worm) glutathione reductase 0.0052 0.0149 0.0381
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0034 0.005
Loa Loa (eye worm) hypothetical protein 0.0054 0.0157 0.0404
Onchocerca volvulus 0.0464 0.1721 1
Mycobacterium ulcerans lipase LipD 0.008 0.0255 0.0672
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0018 0.5
Brugia malayi Pre-SET motif family protein 0.0035 0.0082 0.0231
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0018 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0255 0.2628
Loa Loa (eye worm) hypothetical protein 0.0047 0.0129 0.0324
Schistosoma mansoni hypothetical protein 0.0862 0.3238 0.9149
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0104 0.0347 0.0336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0104 0.0347 0.0951
Schistosoma mansoni hypothetical protein 0.0104 0.0347 0.0951
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0024 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.0792 0.8205
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0444 0.1226
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0404 0.0455
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0255 0.069
Brugia malayi Calcitonin receptor-like protein seb-1 0.0329 0.1205 0.3407
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0018 0.003
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0024 0.0013
Schistosoma mansoni smad 0.0018 0.0016 0.0014
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0034 0.0097
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0034 0.0339
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0034 0.005
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0016 0.0014
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0034 0.0065
Brugia malayi beta-lactamase family protein 0.008 0.0255 0.072
Echinococcus multilocularis dna polymerase eta 0.0022 0.0034 0.0023
Loa Loa (eye worm) hypothetical protein 0.008 0.0255 0.0682
Schistosoma mansoni hypothetical protein 0.0179 0.0631 0.1758
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0941 0.3539 1
Brugia malayi glutathione reductase 0.0052 0.0149 0.042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0104 0.0347 0.098
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0255 0.2628
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0498 0.1382
Trichomonas vaginalis set domain proteins, putative 0.0266 0.0965 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0018 0.002
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0018 0.0174
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0034 0.0023
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0016 0.0014
Echinococcus granulosus smad 0.0018 0.0016 0.0014
Leishmania major trypanothione reductase 0.0052 0.0149 0.0375
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0034 0.005
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.004 0.0073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0104 0.0347 0.0943
Loa Loa (eye worm) hypothetical protein 0.008 0.0255 0.0682
Echinococcus multilocularis Smad4 0.0018 0.0016 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0255 0.2628
Leishmania major hypothetical protein, conserved 0.008 0.0255 0.0676
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0045 0.0452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0045 0.0452
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0255 0.069
Loa Loa (eye worm) hypothetical protein 0.0225 0.0808 0.2252
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Plasmodium vivax glutathione reductase, putative 0.0052 0.0149 0.037
Brugia malayi Bromodomain containing protein 0.0044 0.0118 0.0333
Loa Loa (eye worm) hypothetical protein 0.0104 0.0347 0.0943
Schistosoma mansoni bromodomain containing protein 0.0077 0.0241 0.0652
Echinococcus granulosus dnaJ subfamily B 0.0862 0.3238 0.9149
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0255 0.0672
Echinococcus multilocularis chromobox protein 1 0.007 0.0216 0.0204
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0034 0.0097
Loa Loa (eye worm) hypothetical protein 0.0053 0.015 0.0385
Brugia malayi beta-lactamase 0.008 0.0255 0.072
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0098 0.0195
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0843 0.2352
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0255 0.0699
Schistosoma mansoni hypothetical protein 0.0179 0.0631 0.1758
Echinococcus granulosus thymidylate synthase 0.0464 0.1721 0.4847
Mycobacterium tuberculosis Probable reductase 0.0119 0.0404 0.1096
Toxoplasma gondii thioredoxin reductase 0.0052 0.0149 0.037
Loa Loa (eye worm) hypothetical protein 0.008 0.0255 0.0682
Mycobacterium ulcerans thymidylate synthase 0.0464 0.1721 0.4837
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0033 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.1006
Brugia malayi CXXC zinc finger family protein 0.0061 0.018 0.0509
Onchocerca volvulus 0.0046 0.0125 0.0356
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.018 0.047
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0404 0.1096
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0941 0.3539 1
Trichomonas vaginalis esterase, putative 0.008 0.0255 0.2628
Brugia malayi MH1 domain containing protein 0.0018 0.0016 0.0046
Brugia malayi MH2 domain containing protein 0.0258 0.0933 0.2638
Schistosoma mansoni Smad4 0.0018 0.0016 0.0014
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.0455 0.1241
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0018 0.0005
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0014 0.0003
Brugia malayi Heterochromatin protein 1 0.007 0.0216 0.0609
Echinococcus granulosus dihydrofolate reductase 0.0941 0.3538 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.1006
Echinococcus granulosus chromobox protein 1 0.007 0.0216 0.0579
Loa Loa (eye worm) transcription factor SMAD2 0.0258 0.0933 0.2608
Onchocerca volvulus 0.008 0.0255 0.1139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0157 0.0146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0021 0.0201
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0404 0.1096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0082 0.02
Mycobacterium tuberculosis Hypothetical protein 0.0221 0.0792 0.2198
Plasmodium vivax hypothetical protein, conserved 0.008 0.0255 0.0671
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0255 0.0672
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0843 0.2384
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0255 0.0672
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0104 0.0347 0.0951
Brugia malayi hypothetical protein 0.0221 0.0792 0.2239
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0016 0.0005
Echinococcus granulosus geminin 0.0179 0.0631 0.1758
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0464 0.1721 0.4837
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0082 0.018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0225 0.0214
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0018 0.0005
Schistosoma mansoni smad1 5 8 and 0.0018 0.0016 0.0014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0025 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0034 0.0065
Trypanosoma brucei trypanothione reductase 0.0052 0.0149 0.0399
Onchocerca volvulus 0.008 0.0255 0.1139
Loa Loa (eye worm) hypothetical protein 0.008 0.0255 0.0682
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0941 0.3539 1
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0255 0.0672
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0082 0.007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0255 0.072
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0255 0.0672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0498 0.1382
Brugia malayi Latrophilin receptor protein 2 0.0104 0.0347 0.098
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0034 0.0045
Brugia malayi SET domain containing protein 0.0014 0.0003 0.0007
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0941 0.3539 1
Chlamydia trachomatis dihydrofolate reductase 0.0941 0.3538 1
Onchocerca volvulus 0.008 0.0255 0.1139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0498 0.1382
Trypanosoma brucei ISWI complex protein 0.0018 0.0017 0.0025
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0062 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0045 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0055 0.0554
Trichomonas vaginalis chromobox protein, putative 0.007 0.0216 0.2221
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0464 0.1721 0.4465
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0941 0.3539 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0072 0.0172
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0149 0.0381
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0024 0.0037
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0464 0.1721 0.4847
Loa Loa (eye worm) hypothetical protein 0.0082 0.0261 0.0699
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0255 0.069
Brugia malayi Dihydrofolate reductase 0.0941 0.3538 1
Mycobacterium ulcerans hypothetical protein 0.008 0.0255 0.0672
Schistosoma mansoni zinc finger protein 0.0026 0.0049 0.0106
Mycobacterium tuberculosis Conserved protein 0.008 0.0255 0.0672
Echinococcus multilocularis chromobox protein 1 0.007 0.0216 0.0204
Leishmania major DNA polymerase eta, putative 0.0022 0.0034 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0045 0.0452
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0005
Schistosoma mansoni cpg binding protein 0.0066 0.0202 0.054
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0018 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0157 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0498 0.1382
Mycobacterium tuberculosis Conserved protein 0.008 0.0255 0.0672
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0255 0.2628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0157 0.0412
Mycobacterium tuberculosis Conserved protein 0.008 0.0255 0.0672
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0107 0.0096
Loa Loa (eye worm) hypothetical protein 0.008 0.0255 0.0682
Echinococcus multilocularis dnaJ subfamily B 0.0862 0.3238 0.323
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0404 0.1096
Echinococcus multilocularis zinc finger protein 0.0026 0.0049 0.0037
Trichomonas vaginalis chromobox protein, putative 0.0042 0.011 0.1124
Schistosoma mansoni hypothetical protein 0.0024 0.004 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0045 0.0452
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0015
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0941 0.3538 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0062 0.0143
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0149 0.0375
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0255 0.0244
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0149 0.037
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0941 0.3539 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0025 0.0014
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0221 0.0792 0.2201
Schistosoma mansoni hypothetical protein 0.0104 0.0347 0.0951
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0018 0.5
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0034 0.0023
Giardia lamblia DINP protein human, muc B family 0.0022 0.0034 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0005
Schistosoma mansoni zinc finger protein 0.0018 0.0017 0.0015
Leishmania major DNA polymerase kappa, putative 0.0022 0.0034 0.005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0125 0.0323
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0034 0.0056
Echinococcus multilocularis cpg binding protein 0.0066 0.0202 0.0191
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0034 0.0075
Brugia malayi Smad1 0.0018 0.0016 0.0046
Brugia malayi PHD-finger family protein 0.0032 0.0072 0.0204
Onchocerca volvulus 0.0061 0.018 0.0688
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0255 0.0672
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0329 0.1205 0.338

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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