Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.7043 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0473 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0296 | 0.4422 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0026 | 0.1153 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0026 | 0.1153 | 0.1271 |
Echinococcus granulosus | bloom syndrome protein | 0.0026 | 0.1153 | 0.0884 |
Echinococcus multilocularis | geminin | 0.018 | 1 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0846 | 0.0846 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0005 | 0 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.068 | 0.5 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0473 | 0.5 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0296 | 0.0296 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0026 | 0.1153 | 0.0884 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0473 | 0.5 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0976 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0026 | 0.1153 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0296 | 0.0296 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0668 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0026 | 0.1153 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0296 | 0.4422 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0296 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0473 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.