Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1152 | 0.1152 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.3971 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1152 | 0.1152 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1152 | 0.1152 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.749 | 0.749 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1152 | 0.1152 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.749 | 0.749 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.3971 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.3971 | 0.3971 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0126 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.1152 | 0.1152 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1152 | 0.1152 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4556 | 0.4556 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.4556 | 0.4556 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.1152 | 0.1152 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.3971 | 0.3971 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.3971 | 0.3971 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.4556 | 0.4556 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.3971 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.749 | 0.749 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.1152 | 0.1152 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.3971 | 0.3971 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1152 | 0.1152 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.3971 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1152 | 0.1152 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.1152 | 0.1152 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.749 | 0.749 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1152 | 0.1152 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.3971 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.1152 | 0.1152 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1152 | 0.1152 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.3971 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.