Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1313 | 0.171 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.1345 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.1077 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0603 | 0.3496 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0981 | 0.0901 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0935 | 0.1185 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0017 | 0.0088 | 0.0563 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0981 | 0.151 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0088 | 0.0012 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0584 | 0.3742 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0981 | 0.1248 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.1561 | 0.2043 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0088 | 0.0135 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0981 | 0.6283 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0981 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0017 | 0.0088 | 0.0563 |
Onchocerca volvulus | 0.0099 | 0.3928 | 1 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0017 | 0.0088 | 0.0563 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.108 | 0.7888 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.1077 | 0.6718 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.5022 | 0.4977 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.1561 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0981 | 0.1238 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0981 | 0.151 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0171 | 0.7297 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0603 | 0.3862 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0981 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.14 | 0.183 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0981 | 0.7099 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0981 | 0.1238 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0981 | 0.0901 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.011 | 0.4448 | 0.4399 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0981 | 0.6062 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0981 | 0.7099 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0981 | 0.0901 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2173 | 0.29 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0027 | 0.0584 | 0.3369 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0088 | 0.0012 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.1561 | 0.2052 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2173 | 0.29 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0355 | 0.0381 |
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 0.0584 | 0.3369 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0242 | 0.0225 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0981 | 0.0901 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0981 | 0.1248 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.6184 | 0.9522 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.108 | 0.1663 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.108 | 0.6919 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0603 | 0.3496 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1379 | 0.1801 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1379 | 0.2124 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.5162 | 0.7042 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0584 | 0.3742 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0088 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0328 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0981 | 0.1248 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.1077 | 0.9947 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.2866 | 0.3854 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0143 | 0.5981 | 0.8177 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.011 | 0.4448 | 0.4399 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0027 | 0.0584 | 0.3945 |
Mycobacterium tuberculosis | Probable reductase | 0.011 | 0.4448 | 0.4399 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0017 | 0.0088 | 0.0563 |
Brugia malayi | Flap endonuclease-1 | 0.0027 | 0.0584 | 0.0688 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0079 | 0.0122 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.108 | 0.7888 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0143 | 0.0077 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.108 | 0.7888 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.7297 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0981 | 0.0901 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0088 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0981 | 0.0901 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0981 | 0.1248 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.1345 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0328 | 0.0345 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0017 | 0.0088 | 0.0563 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.5022 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0079 | 0.0122 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0242 | 0.0372 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.1561 | 0.2052 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2511 | 0.3369 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0981 | 0.0901 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0981 | 0.6283 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0981 | 0.1238 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0596 | 0.0706 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0981 | 0.0901 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1379 | 0.2124 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.108 | 0.6919 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1379 | 0.1792 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.108 | 0.1386 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.108 | 0.6919 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0171 | 0.7297 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.5022 | 0.4977 |
Brugia malayi | glutathione reductase | 0.0048 | 0.1561 | 0.2043 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0981 | 0.6283 |
Schistosoma mansoni | flap endonuclease-1 | 0.0025 | 0.0461 | 0.071 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.1561 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.569 | 0.7774 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0088 | 0.5 |
Leishmania major | trypanothione reductase | 0.0048 | 0.1561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0981 | 0.1248 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0603 | 0.0714 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0088 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.1345 | 0.8538 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0981 | 0.1248 |
Loa Loa (eye worm) | acetyltransferase | 0.0143 | 0.5981 | 0.8177 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0027 | 0.0584 | 0.3369 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0027 | 0.0584 | 0.5014 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0981 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.2335 | 0.3595 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0143 | 0.5981 | 0.8175 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0171 | 0.7297 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.1561 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.108 | 0.7888 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0981 | 0.0901 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.1561 | 0.2052 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1203 | 0.1547 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0981 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.108 | 0.7888 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.108 | 0.1386 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.1561 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.108 | 0.7888 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1379 | 0.1801 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.1345 | 0.8538 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0017 | 0.0088 | 0.0563 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0027 | 0.0584 | 0.0699 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.108 | 0.1376 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0981 | 0.1248 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0981 | 0.0901 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.1561 | 0.2052 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0981 | 0.1248 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.1561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0603 | 0.0725 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.108 | 0.7888 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.1345 | 0.1754 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.108 | 0.7888 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0079 | 0.0122 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0981 | 0.7099 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0355 | 0.0546 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0603 | 0.3862 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0603 | 0.3862 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.108 | 0.6735 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0981 | 0.7099 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0981 | 0.1238 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0017 | 0.0088 | 0.0563 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0981 | 0.7099 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0981 | 0.1248 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.108 | 0.6919 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0268 | 0.0261 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.5022 | 0.4977 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0981 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.5162 | 0.7042 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0079 | 0.0122 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0603 | 0.3862 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.1561 | 0.1486 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.108 | 0.1386 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0603 | 0.3496 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0603 | 0.3496 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1045 | 0.1338 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1379 | 0.1801 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0584 | 0.3742 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0328 | 0.0345 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0171 | 0.7297 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1379 | 0.2124 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.011 | 0.4448 | 0.4399 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.6184 | 0.9522 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1379 | 0.1801 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0088 | 0.0563 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.108 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0143 | 0.5981 | 0.921 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.1561 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.1345 | 0.8538 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.108 | 0.7888 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.5162 | 0.7038 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0935 | 0.1185 |
Echinococcus granulosus | flap endonuclease 1 | 0.0027 | 0.0584 | 0.0699 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.011 | 0.4448 | 0.4399 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.108 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0981 | 0.6062 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0981 | 0.7099 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0981 | 0.6283 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.1561 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 0.0584 | 0.0699 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1379 | 0.1801 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.011 | 0.4448 | 0.4399 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.011 | 0.4448 | 0.858 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0355 | 0.0381 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.