Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0104 | 0.3309 | 0.3473 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0176 | 0.5887 | 1 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.01 | 0.3182 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.4646 | 0.4877 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.103 | 0.0593 |
Schistosoma mansoni | polycystin 1-related | 0.004 | 0.103 | 0.1081 |
Trichomonas vaginalis | glutaminase, putative | 0.0277 | 0.9527 | 0.9306 |
Schistosoma mansoni | loxhd1 | 0.004 | 0.103 | 0.1081 |
Brugia malayi | N-terminal motif family protein | 0.0178 | 0.5981 | 0.6208 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0176 | 0.5887 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0141 | 0.4646 | 0.4596 |
Echinococcus granulosus | geminin | 0.0164 | 0.5456 | 0.9269 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.103 | 0.0593 |
Plasmodium falciparum | LCCL domain-containing protein | 0.004 | 0.103 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.4646 | 0.4877 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5981 | 0.6074 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.01 | 0.3182 | 0.5405 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.103 | 0.175 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.004 | 0.103 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.4646 | 0.7893 |
Echinococcus multilocularis | geminin | 0.0164 | 0.5456 | 0.9269 |
Leishmania major | udp-glc 4-epimerase, putative | 0.0104 | 0.3328 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.103 | 0.175 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.103 | 0.1081 |
Loa Loa (eye worm) | glutaminase 2 | 0.0277 | 0.9527 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0495 | 0.034 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.01 | 0.3182 | 0.334 |
Brugia malayi | hypothetical protein | 0.004 | 0.103 | 0.0912 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5456 | 0.5727 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0142 | 0.4679 | 0.5 |
Echinococcus multilocularis | RUN | 0.004 | 0.103 | 0.175 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0141 | 0.4646 | 0.478 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0178 | 0.5981 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.103 | 0.175 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.004 | 0.103 | 0.175 |
Schistosoma mansoni | lipoxygenase | 0.0176 | 0.5887 | 0.6179 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.01 | 0.3182 | 0.5405 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.4646 | 0.7893 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.4646 | 0.7893 |
Schistosoma mansoni | glutaminase | 0.0277 | 0.9527 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.01 | 0.3182 | 1 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.103 | 0.1081 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0291 | 1 | 1 |
Brugia malayi | UDP galactose 4'-epimerase | 0.01 | 0.3182 | 0.3214 |
Echinococcus granulosus | RUN | 0.004 | 0.103 | 0.175 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.004 | 0.103 | 0.175 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.4646 | 0.4877 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.103 | 0.175 |
Brugia malayi | Doublecortin family protein | 0.004 | 0.103 | 0.0912 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0104 | 0.3328 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.004 | 0.103 | 0.0593 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.01 | 0.3182 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.4646 | 0.7893 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.01 | 0.3182 | 0.2975 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.103 | 0.1081 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0142 | 0.4679 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0277 | 0.9527 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5456 | 0.5727 |
Mycobacterium ulcerans | glutaminase | 0.0277 | 0.9527 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.103 | 0.0912 |
Loa Loa (eye worm) | glutaminase | 0.0277 | 0.9527 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.