Detailed information for compound 628903

Basic information

Technical information
  • TDR Targets ID: 628903
  • Name: N'-(4-ethoxy-1,3-benzothiazol-2-yl)-3-fluorob enzohydrazide
  • MW: 331.365 | Formula: C16H14FN3O2S
  • H donors: 2 H acceptors: 2 LogP: 4.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc2c1nc(s2)NNC(=O)c1cccc(c1)F
  • InChi: 1S/C16H14FN3O2S/c1-2-22-12-7-4-8-13-14(12)18-16(23-13)20-19-15(21)10-5-3-6-11(17)9-10/h3-9H,2H2,1H3,(H,18,20)(H,19,21)
  • InChiKey: VIIGRZZEWIZOAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(4-ethoxy-1,3-benzothiazol-2-yl)-3-fluoro-benzohydrazide
  • ZINC00246127

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0094 0.6963 0.6963
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.31 0.31
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0094 0.6963 0.6963
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0116 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.31 0.31
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0094 0.6963 0.8821
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Loa Loa (eye worm) hypothetical protein 0.0116 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1122 0.1421
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.31 0.3927
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.7894 0.7894
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1122 0.1421
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.31 0.31
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.2482 0.4497
Brugia malayi TAR-binding protein 0.0067 0.31 0.3927
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0116 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.7894 0.7894
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.2482 0.4497
Loa Loa (eye worm) hypothetical protein 0.0052 0.1122 0.1122
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.2482 0.4497
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0094 0.6963 0.6963
Brugia malayi Trypsin family protein 0.0101 0.7894 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.31 0.31
Loa Loa (eye worm) RNA binding protein 0.0067 0.31 0.31
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0084 0.5519 0.5519
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.7894 0.7894
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0084 0.5519 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0116 1 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0061 0.2371 0.4296
Brugia malayi RNA binding protein 0.0067 0.31 0.3927
Schistosoma mansoni tar DNA-binding protein 0.0067 0.31 0.31
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1
Onchocerca volvulus 0.0101 0.7894 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0084 0.5519 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0084 0.5519 0.5519
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0116 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.7894 0.7894
Echinococcus granulosus tar DNA binding protein 0.0067 0.31 0.31
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.2371 0.4296
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0084 0.5519 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1122 0.1122
Echinococcus multilocularis tar DNA binding protein 0.0067 0.31 0.31
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0084 0.5519 0.5519
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0116 1 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.31 0.31
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.5519 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.31 0.31
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0084 0.5519 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0084 0.5519 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.5519 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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