TDR Targets

Basic information

Technical information

TDR Targets ID: 628950
Name: N'-(4-chloro-1,3-benzothiazol-2-yl)-4-dimethy laminobenzohydrazide
MW: 346.835 | Formula: C16H15ClN4OS
H donors: 2 H acceptors: 2 LogP: 4.61 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)N(C)C)NNc1sc2c(n1)c(Cl)ccc2
InChi: 1S/C16H15ClN4OS/c1-21(2)11-8-6-10(7-9-11)15(22)19-20-16-18-14-12(17)4-3-5-13(14)23-16/h3-9H,1-2H3,(H,18,20)(H,19,22)
InChiKey: RKCXYSRLFADZBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-(4-chloro-1,3-benzothiazol-2-yl)-4-dimethylamino-benzohydrazide
ZINC04061271

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0113	0.1191	0.3649
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0113	0.1191	0.8646
Loa Loa (eye worm)	hypothetical protein	0.004	0.0106	0.02
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.011	0.115	0.11
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0056	0.0008
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0292	0.0841
Mycobacterium ulcerans	lipase LipD	0.004	0.0106	0.1232
Mycobacterium tuberculosis	Probable oxidoreductase	0.0125	0.1377	0.4221
Echinococcus granulosus	FTZ F1 alpha	0.0412	0.5633	0.5609
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0106	0.0325
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0106	0.1232
Schistosoma mansoni	hypothetical protein	0.0047	0.022	0.0173
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0461	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0049	0.0253	1
Trichomonas vaginalis	esterase, putative	0.004	0.0106	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0106	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0106	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0106	0.005
Schistosoma mansoni	transcription factor LCR-F1	0.011	0.115	0.1107
Entamoeba histolytica	hypothetical protein	0.011	0.115	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0461	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0292	0.0841
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0125	0.1377	0.4221
Loa Loa (eye worm)	hypothetical protein	0.0232	0.2952	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0063	0.0461	0.0407
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0113	0.1191	0.3649
Loa Loa (eye worm)	inositol-1	0.0036	0.0056	0.0028
Loa Loa (eye worm)	glutathione reductase	0.0049	0.0253	0.0704
Toxoplasma gondii	aldehyde dehydrogenase	0.0063	0.0461	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0049	0.0253	0.0774
Onchocerca volvulus		0.0047	0.022	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0106	0.2537
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0106	0.0325
Mycobacterium ulcerans	beta-lactamase	0.004	0.0106	0.1232
Mycobacterium tuberculosis	Probable reductase	0.0113	0.1191	0.3649
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0106	0.02
Toxoplasma gondii	ABC1 family protein	0.004	0.0106	0.1232
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0106	0.1232
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0106	0.2537
Plasmodium falciparum	glutathione reductase	0.0049	0.0253	0.5
Mycobacterium leprae	Probable lipase LipE	0.004	0.0106	0.077
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.0461	0.0415
Mycobacterium tuberculosis	Conserved protein	0.004	0.0106	0.0325
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0113	0.1191	0.3649
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0106	0.0325
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.2952	0.2912
Entamoeba histolytica	hypothetical protein	0.011	0.115	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0106	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0125	0.1377	0.4221
Entamoeba histolytica	hypothetical protein	0.011	0.115	1
Brugia malayi	hypothetical protein	0.011	0.115	0.3794
Schistosoma mansoni	hypothetical protein	0.011	0.115	0.1107
Plasmodium vivax	glutathione reductase, putative	0.0049	0.0253	1
Brugia malayi	glutathione reductase	0.0049	0.0253	0.0704
Brugia malayi	beta-lactamase family protein	0.004	0.0106	0.02
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0106	0.005
Mycobacterium tuberculosis	Conserved protein	0.004	0.0106	0.0325
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.2952	0.2912
Trypanosoma brucei	trypanothione reductase	0.0049	0.0253	1
Brugia malayi	Thioredoxin reductase	0.0049	0.0253	0.0704
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.022	0.0593
Echinococcus multilocularis	microtubule associated protein 2	0.0707	1	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0113	0.1191	0.3649
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0106	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0063	0.0461	0.1412
Plasmodium vivax	thioredoxin reductase, putative	0.0049	0.0253	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0292	0.0841
Brugia malayi	Inositol-1	0.0036	0.0056	0.0028
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0106	0.0325
Plasmodium falciparum	thioredoxin reductase	0.0049	0.0253	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0113	0.1191	0.3649
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0063	0.0461	1
Leishmania major	trypanothione reductase	0.0049	0.0253	0.4855
Schistosoma mansoni	microtubule-associated protein tau	0.0707	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0106	0.02
Brugia malayi	beta-lactamase	0.004	0.0106	0.02
Loa Loa (eye worm)	hypothetical protein	0.004	0.0106	0.02
Entamoeba histolytica	hypothetical protein	0.011	0.115	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0106	0.0325
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0056	0.5
Loa Loa (eye worm)	beta-lactamase	0.004	0.0106	0.02
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0292	0.0841
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0063	0.0461	0.0407
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0106	0.2537
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0106	0.02
Toxoplasma gondii	thioredoxin reductase	0.0049	0.0253	0.4855
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0056	0.0008
Brugia malayi	hypothetical protein	0.0232	0.2952	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0106	0.0058
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.0461	0.0415
Leishmania major	hypothetical protein, conserved	0.004	0.0106	0.1232
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0106	0.0325
Schistosoma mansoni	survival motor neuron protein	0.0047	0.022	0.0173
Loa Loa (eye worm)	hypothetical protein	0.004	0.0106	0.02
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0106	0.0058
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.011	0.115	0.11
Loa Loa (eye worm)	hypothetical protein	0.004	0.0106	0.02
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0049	0.0253	0.0197
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0106	0.0325
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0106	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0106	0.02
Brugia malayi	beta-lactamase family protein	0.004	0.0106	0.02
Loa Loa (eye worm)	thioredoxin reductase	0.0049	0.0253	0.0704
Mycobacterium tuberculosis	Conserved protein	0.004	0.0106	0.0325
Mycobacterium ulcerans	hypothetical protein	0.004	0.0106	0.1232
Echinococcus granulosus	thioredoxin glutathione reductase	0.0049	0.0253	0.0197
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0253	0.3263	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0125	0.1377	1
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0106	0.077
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0461	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 628950