Detailed information for compound 629052

Basic information

Technical information
  • TDR Targets ID: 629052
  • Name: 2-chloro-N-(1,5-dimethyl-3-oxo-2-phenylpyrazo l-4-yl)benzamide
  • MW: 341.792 | Formula: C18H16ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 3.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1C(=O)Nc1c(C)n(n(c1=O)c1ccccc1)C
  • InChi: 1S/C18H16ClN3O2/c1-12-16(20-17(23)14-10-6-7-11-15(14)19)18(24)22(21(12)2)13-8-4-3-5-9-13/h3-11H,1-2H3,(H,20,23)
  • InChiKey: RUQUWLFFIMYLPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)benzamide
  • 2-chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)benzamide
  • 2-chloro-N-(3-keto-1,5-dimethyl-2-phenyl-pyrazol-4-yl)benzamide
  • ST5113066
  • Oprea1_500619
  • ZINC00175718
  • EU-0033933
  • Oprea1_599292
  • Oprea1_365992
  • ZINC04031994
  • 2-Chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-benzamide
  • BAS 00620030

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0381 0.0596
Echinococcus granulosus acylamino acid releasing enzyme 0.0014 0.0099 0.0153
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.051 0.1005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0593 0.474
Plasmodium vivax vivapain-2 0.0095 0.1131 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0219 0.175
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0226 0.1809
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0105 0.1251 0.7496
Giardia lamblia Cathepsin L precursor 0.0024 0.0226 0.1104
Leishmania major kinesin, putative 0.0014 0.0102 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.0097
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0024 0.0226 0.1232
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0024 0.0226 0.1809
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0057 0.0644 0.0637
Leishmania major cathepsin L-like protease 0.0095 0.1131 0.6713
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0014 0.0099 0.0183
Echinococcus multilocularis prolyl endopeptidase 0.0135 0.1636 0.163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0219 0.175
Giardia lamblia Cathepsin L precursor 0.0024 0.0226 0.1104
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0014 0.0099 0.0295
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.5978 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0052 0.0045
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0052 0.0044
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0435 0.3258
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0052 0.0044
Entamoeba histolytica cysteine proteinase 1, putative 0.0053 0.0593 0.4787
Toxoplasma gondii prolyl endopeptidase 0.0135 0.1636 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0275 0.0417
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0593 0.1172
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0219 0.0348
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.022 0.0424
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0593 0.4787
Leishmania major cathepsin L-like protease 0.0095 0.1131 0.6713
Brugia malayi Cathepsin L-like precursor 0.0095 0.1131 0.1856
Brugia malayi Cathepsin L-like precursor 0.0095 0.1131 0.1856
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0026 0.0031
Schistosoma mansoni cpg binding protein 0.003 0.0296 0.0578
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0181 0.0346
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0024 0.0226 0.1232
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0052 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0226 0.1809
Schistosoma mansoni cpg binding protein 0.0028 0.0276 0.0537
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0593 0.1172
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0285 0.3541 0.7071
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0226 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0226 0.0437
Echinococcus granulosus calpain A 0.0057 0.0644 0.1066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0285 0.3541 0.7071
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0024 0.0226 0.1232
Brugia malayi cathepsin Z-like cysteine proteinase 0.0024 0.0226 0.0336
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0435 0.0428
Leishmania major cysteine peptidase A (CPA) 0.0095 0.1131 0.6713
Brugia malayi calpain 7 0.0021 0.0181 0.0259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0286 0.0436
Trichomonas vaginalis ran, putative 0.0021 0.0191 0.1529
Echinococcus granulosus cathepsin L cysteine protease 0.0053 0.0593 0.098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0052 0.0045
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0095 0.1131 0.1124
Echinococcus granulosus calpain A 0.0021 0.0181 0.029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0226 0.0437
Toxoplasma gondii preprocathepsin c precursor, putative 0.0024 0.0226 0.0827
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0099 0.0793
Echinococcus multilocularis Smad4 0.0008 0.0026 0.0019
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0593 0.1172
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0024 0.0226 0.1232
Entamoeba histolytica cysteine protease, putative 0.0024 0.0226 0.1232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0135 0.1636 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0178 0.218 0.2174
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0052 0.0045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0091 0.0108
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0381 0.1833
Giardia lamblia Cathepsin B precursor 0.0105 0.1251 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.051 0.0813
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0181 0.0237
Brugia malayi cathepsin L-like precursor 0.0066 0.0764 0.124
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Echinococcus granulosus cathepsin l cysteine peptidase 0.0095 0.1131 0.1881
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.287 1
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.051 0.0841
Entamoeba histolytica hypothetical protein 0.0037 0.0387 0.2785
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0593 0.0952
Loa Loa (eye worm) hypothetical protein 0.0066 0.0764 0.124
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0029 0.0286 0.0436
Loa Loa (eye worm) hypothetical protein 0.0036 0.0381 0.0596
Loa Loa (eye worm) hypothetical protein 0.0014 0.0099 0.0122
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0181 0.0531
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0593 0.0952
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0593 0.4787
Echinococcus multilocularis RUN 0.0041 0.0435 0.0428
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0226 0.0437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Echinococcus granulosus cathepsin b 0.0285 0.3541 0.5917
Giardia lamblia Cathepsin B precursor 0.0105 0.1251 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0593 0.474
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0286 0.0436
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.0003
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0764 0.1933
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.1131 0.1856
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0105 0.1251 0.2489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0226 0.1809
Brugia malayi calpain 5 0.0014 0.0102 0.0127
Leishmania major oligopeptidase b 0.0054 0.0602 0.3271
Loa Loa (eye worm) hypothetical protein 0.0048 0.0534 0.0853
Loa Loa (eye worm) hypothetical protein 0.0285 0.3541 0.5904
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0381 0.3044
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1155 0.1896
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0435 0.0428
Brugia malayi hypothetical protein 0.0037 0.0387 0.0605
Loa Loa (eye worm) beta-lactamase 0.0036 0.0381 0.0596
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0052 0.0044
Entamoeba histolytica hypothetical protein 0.0037 0.0387 0.2785
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0024 0.0226 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0226 0.1809
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.051 0.0503
Trichomonas vaginalis esterase, putative 0.0036 0.0381 0.3044
Echinococcus multilocularis musashi 0.0028 0.0275 0.0267
Toxoplasma gondii cathepsin CPL 0.0095 0.1131 0.6713
Echinococcus granulosus cathepsin b 0.0285 0.3541 0.5917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0226 0.1809
Giardia lamblia Cathepsin B precursor 0.0024 0.0226 0.1104
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0024 0.0226 0.1232
Giardia lamblia Cathepsin L precursor 0.0024 0.0226 0.1104
Plasmodium falciparum importin beta, putative 0.0029 0.0289 0.1839
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0095 0.1131 0.1124
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Trypanosoma cruzi cysteine protease, putative 0.0053 0.0593 0.1435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0052 0.0075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0613 0.0985
Brugia malayi ecdysteroid receptor 0.001 0.0052 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0381 0.3044
Loa Loa (eye worm) cathepsin B 0.0105 0.1251 0.2058
Onchocerca volvulus Cathepsin L homolog 0.0095 0.1131 0.6811
Entamoeba histolytica hypothetical protein 0.0037 0.0387 0.2785
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0226 0.0336
Entamoeba histolytica cysteine protease, putative 0.0095 0.1131 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0024 0.0226 0.1232
Schistosoma mansoni polycystin 1-related 0.0041 0.0435 0.0856
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0181 0.0531
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0488 0.0775
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Trypanosoma cruzi major cysteine proteinase, putative 0.0024 0.0226 0.0369
Plasmodium vivax importin-beta 2, putative 0.0029 0.0289 0.1839
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Giardia lamblia Encystation-specific protease 0.0024 0.0226 0.1104
Loa Loa (eye worm) hypothetical protein 0.0036 0.0381 0.0596
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0191 0.0893
Onchocerca volvulus Cathepsin L homolog 0.0024 0.0226 0.1098
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.011 0.014
Loa Loa (eye worm) MBCTL1 0.0053 0.0592 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0226 0.1809
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0488 0.048
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0057 0.0644 0.1066
Loa Loa (eye worm) ctsf protein 0.0095 0.1131 0.1856
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0435 0.0716
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.051 0.0503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Echinococcus multilocularis lamin 0.0028 0.0275 0.0267
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0024 0.0226 0.0336
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0026 0.0019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0052 0.0089
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.2248 0.2242
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0052 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0024 0.0226 0.1809
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0052 0.0089
Trypanosoma cruzi prolyl endopeptidase 0.0135 0.1636 0.4466
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0381 0.3044
Brugia malayi calpain family protein 1 0.0055 0.0613 0.0985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.1131 1
Echinococcus granulosus calpain 0.0021 0.0181 0.029
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0099 0.0183
Onchocerca volvulus 0.0036 0.0381 0.2074
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.051 0.289
Schistosoma mansoni cathepsin s 0.0029 0.0286 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0764 0.6108
Onchocerca volvulus 0.0028 0.0275 0.1404
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0095 0.1131 0.1856
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0181 0.0531
Brugia malayi nuclear receptor NHR-88 0.001 0.0052 0.0044
Trypanosoma cruzi kinesin, putative 0.0014 0.0102 0.0009
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0024 0.0226 0.1104
Brugia malayi Cathepsin L-like precursor 0.0029 0.0286 0.0436
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0052 0.0075
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0336
Loa Loa (eye worm) hypothetical protein 0.0029 0.0286 0.0436
Loa Loa (eye worm) hypothetical protein 0.0036 0.0381 0.0596
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0014 0.0099 0.0091
Echinococcus multilocularis acylamino acid releasing enzyme 0.0014 0.0099 0.0091
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.2248 0.3752
Echinococcus granulosus cpg binding protein 0.003 0.0296 0.0484
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0191 0.0599
Leishmania major cathepsin L-like protease 0.0095 0.1131 0.6713
Loa Loa (eye worm) calpain 5 0.0014 0.0102 0.0127
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.2929 0.4876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0052 0.0044
Loa Loa (eye worm) calpain 0.0021 0.0181 0.0259
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0052 0.0089
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.0022
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0289 0.0281
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0024 0.0226 0.1232
Schistosoma mansoni ran 0.0021 0.0191 0.0367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0226 0.0437
Echinococcus multilocularis lamin dm0 0.0028 0.0275 0.0267
Leishmania major cathepsin L-like protease 0.0095 0.1131 0.6713
Leishmania major hypothetical protein, conserved 0.0036 0.0381 0.1833
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0024 0.0226 0.0437
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0285 0.3541 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0024 0.0226 0.1809
Schistosoma mansoni nuclear hormone receptor 0.001 0.0052 0.0089
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0099 0.0122
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0381 0.0596
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0052 0.0075
Echinococcus granulosus dnaJ subfamily B 0.04 0.5004 0.8368
Loa Loa (eye worm) cysteine protease 0.0095 0.1131 0.1856
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0488 0.0804
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0099 0.0122
Echinococcus granulosus cathepsin L 0.0024 0.0226 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.1131 0.2998
Brugia malayi nuclear hormone receptor 0.001 0.0052 0.0044
Brugia malayi steroid hormone receptor 0.001 0.0052 0.0044
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0226 0.0336
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0044
Onchocerca volvulus 0.0046 0.051 0.289
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0024 0.0226 0.0336
Echinococcus granulosus prolyl endopeptidase 0.0135 0.1636 0.2727
Brugia malayi hypothetical protein 0.0476 0.5978 1
Schistosoma mansoni ran 0.0021 0.0191 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0095 0.1131 0.9039
Schistosoma mansoni loxhd1 0.0041 0.0435 0.0856
Giardia lamblia Cysteine protease 0.0024 0.0226 0.1104
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0026 0.0019
Toxoplasma gondii cathepsin CPC2 0.0024 0.0226 0.0827
Leishmania major cathepsin L-like protease 0.0095 0.1131 0.6713
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0054 0.0602 0.3271
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0052 0.0089
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0226 0.1104
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0593 0.1435
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0593 0.4787
Toxoplasma gondii cathepsin B 0.0105 0.1251 0.7496
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0052 0.0089
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0024 0.0226 0.1232
Schistosoma mansoni hypothetical protein 0.0041 0.0435 0.0856
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0226 0.1809
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0191 0.0268
Trypanosoma brucei prolyl oligopeptidase, putative 0.0054 0.0602 0.3271
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0387 0.0758
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0336
Leishmania major GTP-binding protein, putative 0.0021 0.0191 0.0599
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0592 0.0978
Trypanosoma brucei prolyl endopeptidase 0.0135 0.1636 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0644 0.1274
Plasmodium falciparum cysteine proteinase falcipain 1 0.0053 0.0593 0.4787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0052 0.0045
Trypanosoma cruzi major cysteine proteinase, putative 0.0024 0.0226 0.0369
Schistosoma mansoni hypothetical protein 0.031 0.3868 0.7726
Loa Loa (eye worm) hypothetical protein 0.0041 0.0435 0.0687
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0596 0.3229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0226 0.1809
Onchocerca volvulus 0.0095 0.1131 0.6811
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0054 0.0602 0.1461
Giardia lamblia Cysteine protease 0.0024 0.0226 0.1104
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0336
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0024 0.0226 0.1232
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0435 0.0428
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.5978 0.5975
Loa Loa (eye worm) hypothetical protein 0.0041 0.0435 0.0687
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0435 0.0687
Onchocerca volvulus 0.0095 0.1131 0.6811
Giardia lamblia Hypothetical protein 0.0024 0.0226 0.1104
Echinococcus granulosus lamin 0.0028 0.0275 0.0447
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0592 0.0585
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0181 0.0531
Echinococcus granulosus snurportin 1 0.031 0.3868 0.6465
Onchocerca volvulus 0.0095 0.1131 0.6811
Giardia lamblia Cysteine protease 0.0024 0.0226 0.1104
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0024 0.0226 0.1232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0226 0.1809
Loa Loa (eye worm) hypothetical protein 0.0135 0.1636 0.2705
Echinococcus multilocularis cathepsin b 0.0285 0.3541 0.3536
Echinococcus granulosus cathepsin l1 0.0095 0.1131 0.1881
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0336
Plasmodium falciparum serine repeat antigen 2 0.0024 0.0226 0.1232
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.1131 0.2998
Loa Loa (eye worm) hypothetical protein 0.0066 0.0764 0.124
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0054 0.0602 1
Onchocerca volvulus 0.0066 0.0764 0.4495
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0052 0.0044
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0191 0.0893
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0191 0.08
Giardia lamblia Cathepsin B precursor 0.0105 0.1251 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0054 0.0602 0.0888
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0181 0.0531
Schistosoma mansoni importin beta-1 0.0029 0.0289 0.0563
Echinococcus granulosus FTZ F1 alpha 0.001 0.0052 0.0075
Onchocerca volvulus Prolyl endopeptidase homolog 0.0135 0.1636 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0024 0.0226 0.0336
Plasmodium falciparum serine repeat antigen 6 0.0024 0.0226 0.1232
Schistosoma mansoni hypothetical protein 0.0037 0.0387 0.0758
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0181 0.0531
Echinococcus granulosus RUN 0.0041 0.0435 0.0716
Brugia malayi hypothetical protein 0.0041 0.0435 0.0687
Echinococcus granulosus intermediate filament protein 0.0028 0.0275 0.0447
Entamoeba histolytica cysteine protease, putative 0.0024 0.0226 0.1232
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0613 0.0985
Plasmodium falciparum serine repeat antigen 9 0.0024 0.0226 0.1232
Echinococcus granulosus cathepsin L 0.0053 0.0593 0.098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0052 0.0044
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.022 0.0424
Schistosoma mansoni thyroid hormone receptor 0.001 0.0052 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0488 0.0961
Plasmodium falciparum serine repeat antigen 4 0.0024 0.0226 0.1232
Schistosoma mansoni calpain (C02 family) 0.0021 0.0181 0.0346
Entamoeba histolytica cysteine proteinase 2 0.0053 0.0593 0.4787
Echinococcus granulosus calpain 5 0.0021 0.0181 0.029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0052 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0052 0.0044
Trypanosoma cruzi cruzipain precursor, putative 0.0029 0.0286 0.0542
Giardia lamblia Cathepsin L precursor 0.0024 0.0226 0.1104
Echinococcus granulosus smad 0.0008 0.0026 0.0031
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0099 0.0122
Echinococcus multilocularis cathepsin L cysteine protease 0.0095 0.1131 0.1124
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0181 0.029
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0024 0.0226 0.1232
Plasmodium falciparum serine repeat antigen 5 0.0024 0.0226 0.1232
Schistosoma mansoni smad 0.0008 0.0026 0.0037
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0181 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0052 0.0044
Giardia lamblia Cathepsin B precursor 0.0024 0.0226 0.1104
Giardia lamblia Cathepsin L-like protease 0.0024 0.0226 0.1104
Onchocerca volvulus 0.0028 0.0275 0.1404
Trypanosoma brucei antigen, putative 0.0021 0.0181 0.0531
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0105 0.1251 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0191 0.0277
Echinococcus multilocularis hypothetical protein 0.0021 0.0181 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Onchocerca volvulus 0.0095 0.1131 0.6811
Entamoeba histolytica hypothetical protein 0.0037 0.0387 0.2785
Leishmania major importin beta-1 subunit, putative 0.0024 0.0219 0.078
Loa Loa (eye worm) hypothetical protein 0.0036 0.0381 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0052 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0052 0.0044
Plasmodium falciparum cysteine proteinase falcipain 3 0.0095 0.1131 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0052 0.0044
Plasmodium vivax vivapain-3 0.0053 0.0593 0.4787
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0091 0.0083
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0226 0.1104
Brugia malayi Doublecortin family protein 0.0041 0.0435 0.0687
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0191 0.0307
Onchocerca volvulus 0.0028 0.0276 0.1413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0226 0.1809
Entamoeba histolytica cysteine protease, putative 0.0024 0.0226 0.1232
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0052 0.0044
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Echinococcus granulosus lamin dm0 0.0028 0.0275 0.0447
Plasmodium falciparum serine repeat antigen 8 0.0024 0.0226 0.1232
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0052 0.0089
Giardia lamblia Cathepsin B precursor 0.0024 0.0226 0.1104
Giardia lamblia Cathepsin L precursor 0.0024 0.0226 0.1104
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0336
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0121 0.1456 0.432
Loa Loa (eye worm) hypothetical protein 0.0034 0.0351 0.0546
Entamoeba histolytica hypothetical protein 0.0024 0.0219 0.1161
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0435 0.3258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0593 0.3214
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0052 0.0044
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0592 0.095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0488 0.0775
Schistosoma mansoni rab6-interacting 0.0041 0.0435 0.0856
Brugia malayi hypothetical protein 0.0041 0.0435 0.0687
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0593 0.4787
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0593 0.1435
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0381 0.0747
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0488 0.0804
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0014 0.0099 0.0091
Brugia malayi beta-lactamase 0.0036 0.0381 0.0596
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0226 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0052 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0381 0.2731
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0181 0.0531
Echinococcus multilocularis cathepsin L cysteine protease 0.0095 0.1131 0.1124
Echinococcus multilocularis calpain 5 0.0021 0.0181 0.0173
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.1131 0.2998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Brugia malayi cathepsin B-like cysteine proteinase 0.0285 0.3541 0.5904
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0613 0.1211
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.051 0.0813
Echinococcus multilocularis calpain A 0.0057 0.0644 0.0637
Loa Loa (eye worm) hypothetical protein 0.0036 0.0381 0.0596
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Loa Loa (eye worm) hypothetical protein 0.0029 0.0286 0.0436
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0135 0.1636 0.3259
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0024 0.0226 0.1232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Brugia malayi Cathepsin L-like cysteine proteinase 0.0066 0.0764 0.124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Brugia malayi fibroinase precursor 0.0024 0.0226 0.0336
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0052 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0226 0.1809
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.1131 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0052 0.0044
Leishmania major cathepsin L-like protease 0.0095 0.1131 0.6713
Entamoeba histolytica cysteine protease, putative 0.0024 0.0226 0.1232
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0037
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0052 0.0045
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0099 0.0122
Onchocerca volvulus 0.0041 0.0435 0.2418
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0024 0.0226 0.1232
Leishmania major cathepsin L-like protease 0.0095 0.1131 0.6713
Entamoeba histolytica protein kinase, putative 0.0014 0.0102 0.0028
Brugia malayi cathepsin L precursor 0.0024 0.0226 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0052 0.0044
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0014 0.0099 0.0793
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0226 0.1809
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0275 0.0417
Echinococcus multilocularis dnaJ subfamily B 0.04 0.5004 0.5
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0014 0.0099 0.0153
Onchocerca volvulus 0.0095 0.1131 0.6811
Brugia malayi cathepsin L-like cysteine proteinase 0.0024 0.0226 0.0336
Onchocerca volvulus Cathepsin F homolog 0.0095 0.1131 0.6811
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0381 0.0747
Brugia malayi Cathepsin L-like precursor 0.0095 0.1131 0.1856
Plasmodium vivax calpain, putative 0.0021 0.0181 0.0791
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0592 0.1169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0593 0.3214
Loa Loa (eye worm) hypothetical protein 0.0476 0.5978 1
Echinococcus multilocularis cathepsin L 0.0053 0.0593 0.0586
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0181 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0053 0.0593 0.1435
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0219 0.175
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0024 0.0226 0.0437
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0381 0.0625
Echinococcus multilocularis cysteine protease 0.0095 0.1131 0.1124
Schistosoma mansoni intermediate filament proteins 0.0028 0.0275 0.0534
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0044
Plasmodium vivax vivapain-1 0.0053 0.0593 0.4787
Giardia lamblia Cathepsin L-like protease 0.0024 0.0226 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Brugia malayi beta-lactamase family protein 0.0036 0.0381 0.0596
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0406
Plasmodium vivax unspecified product 0.0029 0.0286 0.1809
Echinococcus multilocularis snurportin 1 0.031 0.3868 0.3863
Echinococcus multilocularis calpain 0.0021 0.0181 0.0173
Giardia lamblia Hypothetical protein 0.0024 0.0226 0.1104
Brugia malayi mbt repeat family protein 0.0046 0.051 0.0813
Onchocerca volvulus 0.0036 0.0381 0.2074
Loa Loa (eye worm) hypothetical protein 0.0095 0.1131 0.1856
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Onchocerca volvulus 0.0041 0.0435 0.2418
Schistosoma mansoni cathepsin F (C01 family) 0.0095 0.1131 0.2248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Toxoplasma gondii ABC1 family protein 0.0036 0.0381 0.1833
Entamoeba histolytica calpain large subunit domain III containing protein 0.0014 0.0102 0.0028
Onchocerca volvulus 0.0024 0.0226 0.1098
Schistosoma mansoni hypothetical protein 0.04 0.5004 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0286 0.0436
Echinococcus granulosus cathepsin l1 0.0066 0.0764 0.1267
Plasmodium vivax serine-repeat antigen (SERA) 0.0024 0.0226 0.1232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0052 0.0075
Trypanosoma cruzi oligopeptidase b 0.0054 0.0602 0.1461
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0191 0.0277
Brugia malayi Cathepsin L-like precursor 0.0066 0.0764 0.124
Echinococcus multilocularis cathepsin L 0.0024 0.0226 0.0219
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0024 0.0226 0.1232
Entamoeba histolytica Ran family GTPase 0.0021 0.0191 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Schistosoma mansoni thyroid hormone receptor 0.001 0.0052 0.0089
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1494 0.2466
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0037
Echinococcus granulosus importin subunit beta 1 0.0029 0.0289 0.0471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Trypanosoma brucei oligopeptidase b 0.0054 0.0602 0.3271
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0181 0.0237
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0435 0.0716
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0676 0.1338
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0044
Brugia malayi CXXC zinc finger family protein 0.0028 0.0276 0.042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0387 0.0379
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0095 0.1131 1
Echinococcus multilocularis smad 0.0008 0.0026 0.0019
Onchocerca volvulus 0.0036 0.0381 0.2074
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0054 0.0602 0.3271
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0289 0.1235
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0052 0.0089
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0052 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0381 0.3044
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.1131 0.1856
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0135 0.1636 0.3259
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.051 0.1005
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0764 0.6445
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0014 0.0099 0.0183
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0099 0.0122
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0285 0.3541 0.7071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0181 0.0531
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0181 0.0237
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0052 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Giardia lamblia Cysteine protease 0.0024 0.0226 0.1104
Brugia malayi MH2 domain containing protein 0.0124 0.1494 0.2466
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.011 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0488 0.0961
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0276 0.042
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0289 0.1235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Brugia malayi RNA, U transporter 1 0.0083 0.0971 0.1587
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0381 0.3044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0052 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0226 0.1809
Trypanosoma cruzi cruzipain precursor, putative 0.0095 0.1131 0.2998
Brugia malayi beta-lactamase family protein 0.0036 0.0381 0.0596
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0026 0.0037
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Schistosoma mansoni cathepsin F (C01 family) 0.0095 0.1131 0.2248
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0052 0.0045
Schistosoma mansoni cathepsin B (C01 family) 0.0024 0.0226 0.0437
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0285 0.3541 0.7071
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0381 0.0819
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0592 0.0585
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0044
Trypanosoma cruzi kinesin, putative 0.0014 0.0102 0.0009
Brugia malayi mbt repeat family protein 0.0046 0.051 0.0813
Schistosoma mansoni lamin 0.0028 0.0275 0.0534
Trypanosoma brucei kinesin, putative 0.0014 0.0102 0.0019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0181 0.0237
Entamoeba histolytica hypothetical protein 0.0024 0.0226 0.1232
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0286 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0226 0.1809
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0178 0.218 0.3638
Brugia malayi Cathepsin L-like precursor 0.0095 0.1131 0.1856
Brugia malayi follicle stimulating hormone receptor 0.0237 0.2929 0.4876
Mycobacterium tuberculosis Probable peptidase 0.0054 0.0602 0.0888
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.1131 0.2998
Echinococcus multilocularis cathepsin b 0.0285 0.3541 0.3536
Plasmodium vivax unspecified product 0.0053 0.0593 0.4787
Echinococcus multilocularis cysteine protease 0.0095 0.1131 0.1124
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0435 0.0716
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0105 0.1251 0.3348
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0052 0.0075
Plasmodium falciparum serine repeat antigen 7 0.0024 0.0226 0.1232
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0381 0.0819
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.051 0.1005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0275 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0191 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0181 0.0237
Echinococcus granulosus cathepsin L cysteine proteinase 0.0095 0.1131 0.1881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1131 0.9039
Echinococcus granulosus cysteine protease 0.0053 0.0593 0.098
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0226 0.0336
Trypanosoma brucei cysteine peptidase C (CPC) 0.0105 0.1251 0.7496
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.051 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0095 0.1131 0.9039
Loa Loa (eye worm) fibroinase 0.0095 0.1131 0.1856
Brugia malayi intermediate filament protein 0.0028 0.0275 0.0417
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Loa Loa (eye worm) hypothetical protein 0.0036 0.0381 0.0596
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0052 0.0089
Brugia malayi Cathepsin L-like precursor 0.0095 0.1131 0.1856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0037
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0091 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0052 0.0044
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0052 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0289 0.0441
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0181 0.0237
Giardia lamblia Cathepsin B precursor 0.0024 0.0226 0.1104
Plasmodium falciparum serine repeat antigen 3 0.0024 0.0226 0.1232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1131 0.9039
Plasmodium vivax vivapain-2 0.0095 0.1131 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Brugia malayi prolyl oligopeptidase family protein 0.0135 0.1636 0.2705
Brugia malayi cathepsin F-like cysteine proteinase 0.0024 0.0226 0.0336
Onchocerca volvulus 0.0034 0.0351 0.1886
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0181 0.0237
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0052 0.0045
Echinococcus granulosus Smad4 0.0008 0.0026 0.0031
Plasmodium falciparum serine repeat antigen 1 0.0024 0.0226 0.1232
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0052 0.0045
Schistosoma mansoni Smad4 0.0008 0.0026 0.0037
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0181 0.0237
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0052 0.0045
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0014 0.0099 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0488 0.0961
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.3868 0.6454
Brugia malayi calpain family protein 1 0.0055 0.0613 0.0985
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0099 0.0122
Loa Loa (eye worm) hypothetical protein 0.0066 0.0764 0.124
Schistosoma mansoni lipoxygenase 0.0178 0.218 0.4347
Onchocerca volvulus 0.0097 0.1155 0.6962
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0181 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0764 0.6108
Schistosoma mansoni cathepsin F (C01 family) 0.0066 0.0764 0.1514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Onchocerca volvulus 0.0095 0.1131 0.6811
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0181 0.0346
Entamoeba histolytica cysteine protease, putative 0.0024 0.0226 0.1232
Schistosoma mansoni rab6-interacting 0.0041 0.0435 0.0856
Brugia malayi Importin beta-1 subunit 0.0029 0.0289 0.0441
Schistosoma mansoni lamin 0.0028 0.0275 0.0534
Trypanosoma cruzi oligopeptidase b 0.0054 0.0602 0.1461
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0052 0.0044
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0226 0.1104
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0181 0.0173
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0099 0.0793
Onchocerca volvulus Cathepsin L homolog 0.0095 0.1131 0.6811
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0387 0.0634
Plasmodium vivax unspecified product 0.0024 0.0226 0.1232
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1494 0.2466
Toxoplasma gondii cathepsin CPC1 0.0024 0.0226 0.0827
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0024 0.0226 0.1809
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0226 0.0437
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0095 0.1131 1
Schistosoma mansoni lipoxygenase 0.0105 0.1251 0.2487
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0191 0.0599
Loa Loa (eye worm) hypothetical protein 0.0014 0.0099 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.1131 0.6713
Leishmania major cathepsin L-like protease 0.0095 0.1131 0.6713
Loa Loa (eye worm) histone methyltransferase 0.0009 0.003 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0052 0.0044
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0592 0.0978
Schistosoma mansoni hypothetical protein 0.0097 0.1155 0.2296
Schistosoma mansoni cpg binding protein 0.003 0.0296 0.0578
Schistosoma mansoni survival motor neuron protein 0.0097 0.1155 0.2296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0226 0.1809
Brugia malayi Cathepsin L-like precursor 0.0095 0.1131 0.1856
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0054 0.0602 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0024 0.0226 0.1232
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0289 0.1235
Brugia malayi Cathepsin L-like precursor 0.0066 0.0764 0.124
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0024 0.0226 0.0437
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0054 0.0602 0.1461
Entamoeba histolytica cysteine protease, putative 0.0053 0.0593 0.4787
Entamoeba histolytica cysteine protease, putative 0.0024 0.0226 0.1232
Schistosoma mansoni coup transcription factor 0.001 0.0052 0.0089
Schistosoma mansoni cathepsin C 0.0024 0.0226 0.0437
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0488 0.048
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0026 0.0031
Giardia lamblia Cathepsin L precursor 0.0024 0.0226 0.1104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0052 0.0075
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0381 0.0373
Schistosoma mansoni hypothetical protein 0.0283 0.3512 0.7014
Echinococcus multilocularis calpain family protein 1, d 0.004 0.043 0.0422
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0044
Plasmodium vivax serine-repeat antigen (SERA) 0.0024 0.0226 0.1232
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0275 0.0417
Giardia lamblia Cathepsin B precursor 0.0024 0.0226 0.1104
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0191 0.0184
Loa Loa (eye worm) hypothetical protein 0.004 0.043 0.0678
Schistosoma mansoni cathepsin S (C01 family) 0.0024 0.0226 0.0437
Loa Loa (eye worm) calpain family protein 1 0.004 0.043 0.0678
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0593 0.1435
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0644 0.1274
Echinococcus multilocularis cpg binding protein 0.003 0.0296 0.0289
Echinococcus granulosus Dipeptidyl peptidase 9 0.0014 0.0099 0.0153
Loa Loa (eye worm) hypothetical protein 0.0053 0.0592 0.095
Onchocerca volvulus 0.0095 0.1131 0.6811
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0336

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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