Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0928 | 0.0928 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.181 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.178 | 0.178 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0084 | 0.4725 | 0.5071 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 0.4697 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2755 | 0.2933 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0928 | 0.0928 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0119 | 0.7148 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0084 | 0.4725 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0107 | 0.6323 | 0.8674 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.7777 | 0.7777 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2755 | 0.2717 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.2171 | 0.4533 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3624 | 0.359 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3624 | 0.3624 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.3705 | 0.3672 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.6323 | 0.8837 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3624 | 0.3624 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.181 | 0.4811 |
Onchocerca volvulus | 0.003 | 0.1028 | 0.1135 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2755 | 0.2755 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0249 | 0.0213 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2755 | 0.2755 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0119 | 0.7148 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.3705 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0825 | 0.2114 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.6323 | 0.8837 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.3705 | 0.3672 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0926 | 0.187 |
Brugia malayi | glutathione reductase | 0.0047 | 0.2171 | 0.2171 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3099 | 0.3099 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0249 | 0.0213 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.2171 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3099 | 0.3099 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.2171 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 1 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0928 | 0.088 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0249 | 0.0249 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0249 | 0.0197 |
Schistosoma mansoni | lamin | 0.0029 | 0.0928 | 0.095 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0029 | 0.0926 | 0.187 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0249 | 0.0197 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0249 | 0.0197 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0249 | 0.0197 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0055 | 0.2728 | 0.2896 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0055 | 0.2728 | 0.269 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3099 | 0.3099 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.2171 | 0.4533 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0055 | 0.2728 | 0.3771 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.1606 | 0.1606 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0084 | 0.4725 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0928 | 0.088 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0084 | 0.4725 | 0.6106 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3624 | 0.359 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0928 | 0.095 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0249 | 0.0249 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0928 | 0.088 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0928 | 0.0928 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0029 | 0.0926 | 0.187 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0891 | 0.0891 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.6323 | 0.8837 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.3705 | 0.3672 |
Echinococcus granulosus | lamin | 0.0029 | 0.0928 | 0.088 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0928 | 0.088 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.3705 | 0.3964 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0249 | 0.0197 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0084 | 0.4725 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2755 | 0.2933 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3624 | 0.3876 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.1606 | 0.7695 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.6323 | 0.8837 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0249 | 0.0213 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.6323 | 0.8837 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.2171 | 0.2171 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.2171 | 0.2985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3624 | 0.3876 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.7777 | 0.7777 |
Brugia malayi | Probable ClpP-like protease | 0.0084 | 0.4725 | 0.4725 |
Echinococcus granulosus | muscleblind protein | 0.016 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3624 | 0.3876 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3624 | 0.3624 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.2171 | 0.2171 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.2171 | 0.2171 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0928 | 0.0928 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 0.4697 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0928 | 0.0928 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0249 | 0.0197 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.6323 | 0.8837 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3099 | 0.3099 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.3705 | 0.3672 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2755 | 0.2717 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0119 | 0.7148 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2755 | 0.2933 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3624 | 0.3876 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3624 | 0.3876 |
Schistosoma mansoni | lamin | 0.0029 | 0.0928 | 0.095 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.7777 | 0.7777 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.181 | 0.4811 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.4725 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0825 | 0.2114 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3624 | 0.3624 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.2171 | 0.4533 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2755 | 0.2717 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1606 | 0.1606 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.3705 | 0.3964 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0055 | 0.2728 | 0.3771 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.178 | 0.1875 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0055 | 0.2728 | 0.269 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.3705 | 0.3705 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.3705 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0119 | 0.7148 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.2171 | 0.2129 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0053 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.3705 | 0.3705 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.2171 | 0.4533 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.178 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4725 | 0.4725 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.2171 | 0.2129 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1606 | 0.4254 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3624 | 0.3624 |
Brugia malayi | RNA binding protein | 0.0068 | 0.3624 | 0.3624 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0928 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1028 | 0.1028 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0249 | 0.0213 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1606 | 0.4254 |
Leishmania major | trypanothione reductase | 0.0047 | 0.2171 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0029 | 0.0926 | 0.187 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2755 | 0.2717 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.2171 | 0.4533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.