TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.779 | Formula: C15H11ClN2OS
H donors: 0 H acceptors: 1 LogP: 4.21 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)C(=O)N=c1sc2c(n1C)cccc2
InChi: 1S/C15H11ClN2OS/c1-18-12-7-2-3-8-13(12)20-15(18)17-14(19)10-5-4-6-11(16)9-10/h2-9H,1H3/b17-15-
InChiKey: NPQSTWUNZJJIBA-ICFOKQHNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.1004	0.199
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.5044	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0045	0.1745	0.3459
Brugia malayi	follicle stimulating hormone receptor	0.0229	1	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0956	0.1895
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0145	0.0288
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0016	0.0447	0.0887
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.1143	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0145	0.0288
Echinococcus granulosus	zinc finger protein	0.0019	0.0557	0.1104
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0145	0.0288
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.1268	0.2514
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0145	0.0145
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0119	0.5044	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0145	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0068	0.278	0.278
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0145	0.0288
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0447	0.0887
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0542	0.1075
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0145	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0041	0.156	0.156
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0045	0.1745	0.3459
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.1004	0.199
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0145	0.0145
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.1311	0.1311
Onchocerca volvulus		0.001	0.0145	0.0145
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0145	0.0145
Schistosoma mansoni	ap endonuclease	0.0019	0.0542	0.1075
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0045	0.1745	0.3459
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0145	0.0288
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0145	0.0145
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.5044	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0145	0.0145
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0686	0.136
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.1311	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0542	0.0542
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0119	0.5044	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0542	0.4134
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0542	0.4134
Toxoplasma gondii	exonuclease III APE	0.0019	0.0542	0.1075
Leishmania major	hypothetical protein, conserved	0.0015	0.0371	0.0736
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0542	1
Loa Loa (eye worm)	inositol-1	0.0036	0.1311	0.1311
Schistosoma mansoni	hypothetical protein	0.0015	0.0371	0.0736
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0542	0.1075
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.1311	1
Brugia malayi	Pre-SET motif family protein	0.0201	0.875	0.8751
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.1311	0.1311
Toxoplasma gondii	aldehyde dehydrogenase	0.0119	0.5044	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0447	0.0887
Schistosoma mansoni	aldehyde dehydrogenase	0.0119	0.5044	1
Trypanosoma brucei	ISWI complex protein	0.0015	0.0371	0.283
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.1311	0.26
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.001	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.001	0.0145	0.0145
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.1143	0.2267
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0145	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0145	0.0145
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0145	0.0145
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0145	0.0288
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0145	0.0145
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0145	0.0145
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0542	0.1075
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0145	0.0288
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0145	0.0288
Schistosoma mansoni	hypothetical protein	0.002	0.0603	0.1195
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0542	0.0542
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.1311	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0145	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0145	0.0145
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0542	0.4134
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0371	0.283
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.1311	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0145	0.0145
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0542	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0145	0.0145
Plasmodium vivax	SET domain protein, putative	0.0029	0.1004	1
Brugia malayi	Pre-SET motif family protein	0.0029	0.1004	0.1004
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0145	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1745	0.1745
Echinococcus granulosus	histone lysine methyltransferase setb	0.0045	0.1745	0.3459
Schistosoma mansoni	zinc finger protein	0.0019	0.0557	0.1104
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0145	0.0288
Loa Loa (eye worm)	hypothetical protein	0.001	0.0145	0.0145
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.5044	1
Brugia malayi	Bromodomain containing protein	0.0037	0.1371	0.1371
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0145	0.0288
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0119	0.5044	1
Brugia malayi	nuclear receptor NHR-88	0.001	0.0145	0.0145
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0542	0.0542
Schistosoma mansoni	aldehyde dehydrogenase	0.0119	0.5044	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0542	0.0542
Onchocerca volvulus		0.0029	0.1004	0.1004
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.1004	0.199
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0145	0.0145
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0016	0.0447	0.0887
Schistosoma mansoni	zinc finger protein	0.0015	0.0371	0.0736
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0145	0.0288
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0145	0.0288
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0145	0.0288
Schistosoma mansoni	inositol monophosphatase	0.0036	0.1311	0.26
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.1311	0.26
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0145	0.0288
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0145	0.0145
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.1311	0.1311
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0119	0.5044	1
Schistosoma mansoni	bromodomain containing protein	0.0061	0.2456	0.487
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.875	0.8751
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.1311	0.26
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0145	0.0288
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0542	0.1075
Brugia malayi	PHD-finger family protein	0.0024	0.0789	0.0789
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0145	0.0145
Echinococcus multilocularis	zinc finger protein	0.0019	0.0557	0.1104
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0686	0.136
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0542	0.4134
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1374	0.1374
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0145	0.0145
Brugia malayi	ecdysteroid receptor	0.001	0.0145	0.0145
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0145	0.0288
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0145	0.0288
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.1311	0.26
Schistosoma mansoni	coup transcription factor	0.001	0.0145	0.0288
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0145	0.0288
Brugia malayi	Bromodomain containing protein	0.0072	0.2965	0.2965
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.1004	0.199
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0145	0.0145
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0371	0.283
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.001	0.0145	0.0145
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0542	0.4134
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0145	0.0288
Trichomonas vaginalis	set domain proteins, putative	0.0229	1	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0542	0.1075
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0474	0.0474
Schistosoma mansoni	ap endonuclease	0.0019	0.0542	0.1075
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1477	0.1477
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0145	0.0288
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.1311	0.26
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0145	0.0288
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0145	0.0288
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0145	0.0288
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0145	0.0145
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0145	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0145	0.0145
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0603	0.0603
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0542	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0686	0.136
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0145	0.0288
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0145	0.0288
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.1311	1
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0145	0.0288
Schistosoma mansoni	inositol monophosphatase	0.0036	0.1311	0.26
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0145	0.0288
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.2301	0.4562
Loa Loa (eye worm)	hypothetical protein	0.001	0.0145	0.0145
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.1268	0.2514
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0145	0.0145
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0145	0.0145
Brugia malayi	nuclear hormone receptor	0.001	0.0145	0.0145
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0145	0.0288
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0229	1	1
Brugia malayi	steroid hormone receptor	0.001	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.001	0.0145	0.0145
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.2301	0.4562
Brugia malayi	Inositol-1	0.0036	0.1311	0.1311

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 629107