TDR Targets

Basic information

Technical information

TDR Targets ID: 629153
Name: 5-chloro-N-[4-(4-nitrophenyl)-1,3-thiazol-2-y l]thiophene-2-carboxamide
MW: 365.815 | Formula: C14H8ClN3O3S2
H donors: 1 H acceptors: 4 LogP: 4.59 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(s1)C(=O)Nc1scc(n1)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C14H8ClN3O3S2/c15-12-6-5-11(23-12)13(19)17-14-16-10(7-22-14)8-1-3-9(4-2-8)18(20)21/h1-7H,(H,16,17,19)
InChiKey: ZNLUFTXZJZAAQJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-chloro-N-[4-(4-nitrophenyl)thiazol-2-yl]thiophene-2-carboxamide
5-chloro-N-[4-(4-nitrophenyl)-2-thiazolyl]-2-thiophenecarboxamide
ZINC04070271
EU-0003640

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0366	0.0368
Brugia malayi	hypothetical protein	0.0042	0.3197	0.3162
Schistosoma mansoni	smad	0.0008	0.0366	0.0782
Brugia malayi	Cytochrome P450 family protein	0.0022	0.1508	0.1465
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.3442	0.3408
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0022	0.1508	0.5
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.1735	1
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0022	0.1508	0.5
Schistosoma mansoni	hypothetical protein	0.0022	0.1508	0.3227
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.3442	1
Schistosoma mansoni	cpg binding protein	0.003	0.2159	0.4619
Echinococcus multilocularis	cpg binding protein	0.003	0.2159	0.5982
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0022	0.1508	0.5
Loa Loa (eye worm)	CYP4Cod1	0.0022	0.1508	0.1465
Loa Loa (eye worm)	Smad1	0.0008	0.0366	0.0316
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0022	0.1508	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0196	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0591	0.1075
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.3197	0.6842
Entamoeba histolytica	hypothetical protein	0.0042	0.3197	0.5
Brugia malayi	Cytochrome P450 family protein	0.0022	0.1508	0.1465
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0022	0.1508	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.3197	0.9234
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.3442	0.3408
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	1	1
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0022	0.1508	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Leishmania major	hypothetical protein, conserved	0.0025	0.1735	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0366	0.0316
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.1735	0.5
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0022	0.1508	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0392	0.0451
Mycobacterium leprae	Conserved hypothetical protein	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0022	0.1508	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.1508	0.1465
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0383	0.0334
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0366	0.0782
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0022	0.1508	0.5
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0591	0.1075
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0196	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0196	0.5
Echinococcus multilocularis	smad	0.0008	0.0366	0.0368
Schistosoma mansoni	cytochrome P450	0.0022	0.1508	0.3227
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0022	0.1508	0.5
Echinococcus granulosus	smad	0.0008	0.0366	0.0368
Schistosoma mansoni	cpg binding protein	0.0028	0.2024	0.4331
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0022	0.1508	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.3442	1
Loa Loa (eye worm)	cytochrome P450	0.0022	0.1508	0.1465
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0196	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0022	0.1508	0.5
Brugia malayi	hypothetical protein	0.0016	0.1	0.0954
Mycobacterium leprae	putative cytochrome p450	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0022	0.1508	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.3442	1
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0022	0.1508	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.4138	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.1508	0.1465
Schistosoma mansoni	hypothetical protein	0.0042	0.3197	0.6842
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0392	0.0343
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0022	0.1508	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.4673	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0196	0.5
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0022	0.1508	0.5
Brugia malayi	MH1 domain containing protein	0.0008	0.0366	0.0316
Entamoeba histolytica	hypothetical protein	0.0042	0.3197	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.1735	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.3442	0.7365
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.3442	0.7365
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0366	0.0368
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.1735	0.0863
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0022	0.1508	0.5
Brugia malayi	cytochrome P450	0.0022	0.1508	0.1465
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0022	0.1508	0.5
Brugia malayi	Cytochrome P450 family protein	0.0022	0.1508	0.1465
Brugia malayi	Cytochrome P450 family protein	0.0022	0.1508	0.1465
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0022	0.1508	0.5
Schistosoma mansoni	Smad4	0.0008	0.0366	0.0782
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0248	0.0531
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0366	0.0782
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.2024	0.1983
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0022	0.1508	0.5
Brugia malayi	Smad1	0.0008	0.0366	0.0316
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0022	0.1508	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.1735	0.5
Echinococcus granulosus	cpg binding protein	0.003	0.2159	0.5982
Schistosoma mansoni	cpg binding protein	0.003	0.2159	0.4619
Onchocerca volvulus		0.0028	0.2024	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.3442	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0392	0.0451
Echinococcus granulosus	cytochrome P450 2K1	0.0022	0.1508	0.3945
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.3197	0.9234
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0022	0.1508	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.1508	0.1465
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0022	0.1508	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.3442	0.7365
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0022	0.1508	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0196	0.5
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0366	0.0782
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Echinococcus multilocularis		0.0022	0.1508	0.3945
Brugia malayi	MH2 domain containing protein	0.0008	0.0366	0.0316
Echinococcus multilocularis	Smad4	0.0008	0.0366	0.0368
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0366	0.0782
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	1	1
Brugia malayi	MH2 domain containing protein	0.0008	0.0366	0.0316
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.1735	1
Entamoeba histolytica	hypothetical protein	0.0042	0.3197	0.5
Trichomonas vaginalis	helicase, putative	0.0006	0.0196	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1735	0.1693
Brugia malayi	hypothetical protein	0.0025	0.1735	0.1693
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0366	0.0368
Echinococcus granulosus	Smad4	0.0008	0.0366	0.0368
Entamoeba histolytica	hypothetical protein	0.0042	0.3197	0.5
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0366	0.0316
Brugia malayi	MH1 domain containing protein	0.0008	0.0366	0.0316
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0196	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0196	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0196	0.5
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0022	0.1508	0.5
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0022	0.1508	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0022	0.1508	0.5
Brugia malayi	CXXC zinc finger family protein	0.0028	0.2024	0.1983
Schistosoma mansoni	hypothetical protein	0.0011	0.0591	0.1265
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0366	0.0368
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.1735	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 629153